eF-site ID 3my0-V PDB Code 3my0 Chain V click to enlarge Title Crystal structure of the ACVRL1 (ALK1) kinase domain bound to LDN-193189 Classification TRANSFERASE Compound Serine/threonine-protein kinase receptor R3 Source Homo sapiens (Human) (ACVL1_HUMAN) Sequence V:  MQRTVARQVALVECVGKGRYGEVWRGLWHGESVAVKIFSS RDEQSWFRETEIYNTVLLRHDNILGFIASDMTTQLWLITH YHEHGSLYDFLQRQTLEPHLALRLAVSAACGLAHLHVEIK PAIAHRDFKSRNVLVKSNLQCCIADLGLAVMDIGNNPRVG TKRYMAPEVLDEQIRTDCFESYKWTDIWAFGLVLWEIARR TIVNGIVEDYRPPFYDVVPNDPSFEDMKKVVCVDQQTPTI PNRLAADPVLSGLAQMMRECWYPNPSARLTALRIKKTLQK IS Description Functional site 1) chain V residue 216 type sequence V description BINDING SITE FOR RESIDUE LDN V 600 source : CC4 2) chain V residue 227 type sequence A description BINDING SITE FOR RESIDUE LDN V 600 source : CC4 3) chain V residue 257 type sequence L description BINDING SITE FOR RESIDUE LDN V 600 source : CC4 4) chain V residue 277 type sequence T description BINDING SITE FOR RESIDUE LDN V 600 source : CC4 5) chain V residue 278 type sequence H description BINDING SITE FOR RESIDUE LDN V 600 source : CC4 6) chain V residue 279 type sequence Y description BINDING SITE FOR RESIDUE LDN V 600 source : CC4 7) chain V residue 280 type sequence H description BINDING SITE FOR RESIDUE LDN V 600 source : CC4 8) chain V residue 281 type sequence E description BINDING SITE FOR RESIDUE LDN V 600 source : CC4 9) chain V residue 283 type sequence G description BINDING SITE FOR RESIDUE LDN V 600 source : CC4 10) chain V residue 287 type sequence D description BINDING SITE FOR RESIDUE LDN V 600 source : CC4 11) chain V residue 334 type sequence R description BINDING SITE FOR RESIDUE LDN V 600 source : CC4 12) chain V residue 335 type sequence N description BINDING SITE FOR RESIDUE LDN V 600 source : CC4 13) chain V residue 337 type sequence L description BINDING SITE FOR RESIDUE LDN V 600 source : CC4 14) chain V residue 347 type sequence A description BINDING SITE FOR RESIDUE LDN V 600 source : CC4 15) chain V residue 330 type ACT_SITE sequence D description Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027 source Swiss-Prot : SWS_FT_FI1 16) chain V residue 208 type BINDING sequence V description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159 source Swiss-Prot : SWS_FT_FI2 17) chain V residue 229 type BINDING sequence K description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159 source Swiss-Prot : SWS_FT_FI2

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