eF-site ID 3my0-R PDB Code 3my0 Chain R click to enlarge Title Crystal structure of the ACVRL1 (ALK1) kinase domain bound to LDN-193189 Classification TRANSFERASE Compound Serine/threonine-protein kinase receptor R3 Source Homo sapiens (Human) (ACVL1_HUMAN) Sequence R:  MQRTVARQVALVECVGKGRYGEVWRGLWHGESVAVKIFSS RDEQSWFRETEIYNTVLLRHDNILGFIASDMTQLWLITHY HEHGSLYDFLQRQTLEPHLALRLAVSAACGLAHLHVEIFG TQGKPAIAHRDFKSRNVLVKSNLQCCIADLGLAVMHSQGS DYLDIGNNPRVGTKRYMAPEVLDEQIRTDCFESYKWTDIW AFGLVLWEIARRTIVNGIVEDYRPPFYDVVPNDPSFEDMK KVVCVDQQTPTIPNRLAADPVLSGLAQMMRECWYPNPSAR LTALRIKKTLQKIS Description Functional site 1) chain R residue 227 type sequence A description BINDING SITE FOR RESIDUE LDN R 600 source : BC9 2) chain R residue 257 type sequence L description BINDING SITE FOR RESIDUE LDN R 600 source : BC9 3) chain R residue 277 type sequence T description BINDING SITE FOR RESIDUE LDN R 600 source : BC9 4) chain R residue 278 type sequence H description BINDING SITE FOR RESIDUE LDN R 600 source : BC9 5) chain R residue 280 type sequence H description BINDING SITE FOR RESIDUE LDN R 600 source : BC9 6) chain R residue 281 type sequence E description BINDING SITE FOR RESIDUE LDN R 600 source : BC9 7) chain R residue 283 type sequence G description BINDING SITE FOR RESIDUE LDN R 600 source : BC9 8) chain R residue 287 type sequence D description BINDING SITE FOR RESIDUE LDN R 600 source : BC9 9) chain R residue 335 type sequence N description BINDING SITE FOR RESIDUE LDN R 600 source : BC9 10) chain R residue 337 type sequence L description BINDING SITE FOR RESIDUE LDN R 600 source : BC9 11) chain R residue 347 type sequence A description BINDING SITE FOR RESIDUE LDN R 600 source : BC9 12) chain R residue 291 type sequence R description BINDING SITE FOR RESIDUE LDN U 600 source : CC3 13) chain R residue 330 type ACT_SITE sequence D description Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027 source Swiss-Prot : SWS_FT_FI1 14) chain R residue 208 type BINDING sequence V description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159 source Swiss-Prot : SWS_FT_FI2 15) chain R residue 229 type BINDING sequence K description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159 source Swiss-Prot : SWS_FT_FI2

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