eF-site ID 3my0-P PDB Code 3my0 Chain P click to enlarge Title Crystal structure of the ACVRL1 (ALK1) kinase domain bound to LDN-193189 Classification TRANSFERASE Compound Serine/threonine-protein kinase receptor R3 Source Homo sapiens (Human) (ACVL1_HUMAN) Sequence P:  QRTVARQVALVECVGKGRYGEVWRGLWHGESVAVKIFSSR DEQSWFRETEIYNTVLLRHDNILGFIASDMQLWLITHYHE HGSLYDFLQRQTLEPHLALRLAVSAACGLAHLHVEITQGK PAIAHRDFKSRNVLVKSNLQCCIADLGLAVMHSQGSDYLD IGNNPRVGTKRYMAPEVLDEQIRTDCFESYKWTDIWAFGL VLWEIARRTIVNGIVEDYRPPFYDVVPNDPSFEDMKKVVC VDQQTPTIPNRLAADPVLSGLAQMMRECWYPNPSARLTAL RIKKTLQKIS Description Functional site 1) chain P residue 208 type sequence V description BINDING SITE FOR RESIDUE LDN P 600 source : BC7 2) chain P residue 227 type sequence A description BINDING SITE FOR RESIDUE LDN P 600 source : BC7 3) chain P residue 229 type sequence K description BINDING SITE FOR RESIDUE LDN P 600 source : BC7 4) chain P residue 257 type sequence L description BINDING SITE FOR RESIDUE LDN P 600 source : BC7 5) chain P residue 277 type sequence T description BINDING SITE FOR RESIDUE LDN P 600 source : BC7 6) chain P residue 278 type sequence H description BINDING SITE FOR RESIDUE LDN P 600 source : BC7 7) chain P residue 280 type sequence H description BINDING SITE FOR RESIDUE LDN P 600 source : BC7 8) chain P residue 281 type sequence E description BINDING SITE FOR RESIDUE LDN P 600 source : BC7 9) chain P residue 283 type sequence G description BINDING SITE FOR RESIDUE LDN P 600 source : BC7 10) chain P residue 287 type sequence D description BINDING SITE FOR RESIDUE LDN P 600 source : BC7 11) chain P residue 334 type sequence R description BINDING SITE FOR RESIDUE LDN P 600 source : BC7 12) chain P residue 335 type sequence N description BINDING SITE FOR RESIDUE LDN P 600 source : BC7 13) chain P residue 337 type sequence L description BINDING SITE FOR RESIDUE LDN P 600 source : BC7 14) chain P residue 347 type sequence A description BINDING SITE FOR RESIDUE LDN P 600 source : BC7 15) chain P residue 291 type sequence R description BINDING SITE FOR RESIDUE LDN S 600 source : CC1 16) chain P residue 330 type ACT_SITE sequence D description Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027 source Swiss-Prot : SWS_FT_FI1 17) chain P residue 208 type BINDING sequence V description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159 source Swiss-Prot : SWS_FT_FI2 18) chain P residue 229 type BINDING sequence K description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159 source Swiss-Prot : SWS_FT_FI2

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