eF-site ID 3my0-K PDB Code 3my0 Chain K click to enlarge Title Crystal structure of the ACVRL1 (ALK1) kinase domain bound to LDN-193189 Classification TRANSFERASE Compound Serine/threonine-protein kinase receptor R3 Source null (ACVL1_HUMAN) Sequence K:  QRTVARQVALVECVGKGRYGEVWRGLWHGESVAVKIFSSR DEQSWFRETEIYNTVLLRHDNILGFIASDMTTQLWLITHY HEHGSLYDFLQRQTLEPHLALRLAVSAACGLAHLHVEIKP AIAHRDFKSRNVLVKSNLQCCIADLGLAVDIGNNPRVGTK RYMAPEVLDEQIRTDCFESYKWTDIWAFGLVLWEIARRTI VEDYRPPFYDVVPNDPSFEDMKKVVCVDQQTPLAQMMREC WYPNPSARLTALRIKKTLQKI Description Functional site 1) chain K residue 208 type sequence V description BINDING SITE FOR RESIDUE LDN K 600 source : BC2 2) chain K residue 227 type sequence A description BINDING SITE FOR RESIDUE LDN K 600 source : BC2 3) chain K residue 257 type sequence L description BINDING SITE FOR RESIDUE LDN K 600 source : BC2 4) chain K residue 277 type sequence T description BINDING SITE FOR RESIDUE LDN K 600 source : BC2 5) chain K residue 278 type sequence H description BINDING SITE FOR RESIDUE LDN K 600 source : BC2 6) chain K residue 279 type sequence Y description BINDING SITE FOR RESIDUE LDN K 600 source : BC2 7) chain K residue 280 type sequence H description BINDING SITE FOR RESIDUE LDN K 600 source : BC2 8) chain K residue 283 type sequence G description BINDING SITE FOR RESIDUE LDN K 600 source : BC2 9) chain K residue 287 type sequence D description BINDING SITE FOR RESIDUE LDN K 600 source : BC2 10) chain K residue 337 type sequence L description BINDING SITE FOR RESIDUE LDN K 600 source : BC2 11) chain K residue 347 type sequence A description BINDING SITE FOR RESIDUE LDN K 600 source : BC2 12) chain K residue 348 type sequence D description BINDING SITE FOR RESIDUE LDN K 600 source : BC2 13) chain K residue 330 type ACT_SITE sequence D description Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027 source Swiss-Prot : SWS_FT_FI1 14) chain K residue 208 type BINDING sequence V description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159 source Swiss-Prot : SWS_FT_FI2 15) chain K residue 229 type BINDING sequence K description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159 source Swiss-Prot : SWS_FT_FI2

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