eF-site ID 3my0-H PDB Code 3my0 Chain H click to enlarge Title Crystal structure of the ACVRL1 (ALK1) kinase domain bound to LDN-193189 Classification TRANSFERASE Compound Serine/threonine-protein kinase receptor R3 Source null (ACVL1_HUMAN) Sequence H:  MQRTVARQVALVECVGKGRYGEVWRGLWHGESVAVKIFSS RDEQSWFRETEIYNTVLLRHDNILGFIASDMTSQLWLITH YHEHGSLYDFLQRQTLEPHLALRLAVSAACGLAHLHVEIF GTQGKPAIAHRDFKSRNVLVKSNLQCCIADLGLAVMHSQG SDYLDIGNNPRVGTKRYMAPEVLDEQIRTDCFESYKWTDI WAFGLVLWEIARRTIVNGIVEDYRPPFYDVVPNDPSFEDM KKVVCVDQQTPTIPNRLAADPVLSGLAQMMRECWYPNPSA RLTALRIKKTLQKI Description Functional site 1) chain H residue 291 type sequence R description BINDING SITE FOR RESIDUE LDN E 600 source : AC5 2) chain H residue 227 type sequence A description BINDING SITE FOR RESIDUE LDN H 600 source : AC8 3) chain H residue 257 type sequence L description BINDING SITE FOR RESIDUE LDN H 600 source : AC8 4) chain H residue 277 type sequence T description BINDING SITE FOR RESIDUE LDN H 600 source : AC8 5) chain H residue 278 type sequence H description BINDING SITE FOR RESIDUE LDN H 600 source : AC8 6) chain H residue 279 type sequence Y description BINDING SITE FOR RESIDUE LDN H 600 source : AC8 7) chain H residue 280 type sequence H description BINDING SITE FOR RESIDUE LDN H 600 source : AC8 8) chain H residue 281 type sequence E description BINDING SITE FOR RESIDUE LDN H 600 source : AC8 9) chain H residue 283 type sequence G description BINDING SITE FOR RESIDUE LDN H 600 source : AC8 10) chain H residue 287 type sequence D description BINDING SITE FOR RESIDUE LDN H 600 source : AC8 11) chain H residue 334 type sequence R description BINDING SITE FOR RESIDUE LDN H 600 source : AC8 12) chain H residue 335 type sequence N description BINDING SITE FOR RESIDUE LDN H 600 source : AC8 13) chain H residue 337 type sequence L description BINDING SITE FOR RESIDUE LDN H 600 source : AC8 14) chain H residue 347 type sequence A description BINDING SITE FOR RESIDUE LDN H 600 source : AC8 15) chain H residue 330 type ACT_SITE sequence D description Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027 source Swiss-Prot : SWS_FT_FI1 16) chain H residue 208 type BINDING sequence V description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159 source Swiss-Prot : SWS_FT_FI2 17) chain H residue 229 type BINDING sequence K description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159 source Swiss-Prot : SWS_FT_FI2

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