eF-site ID 3my0-F PDB Code 3my0 Chain F click to enlarge Title Crystal structure of the ACVRL1 (ALK1) kinase domain bound to LDN-193189 Classification TRANSFERASE Compound Serine/threonine-protein kinase receptor R3 Source Homo sapiens (Human) (ACVL1_HUMAN) Sequence F:  MQRTVARQVALVECVGKGRYGEVWRGLWHGESVAVKIFSS RDEQSWFRETEIYNTVLLRHDNILGFIASDMTQLWLITHY HEHGSLYDFLQRQTLEPHLALRLAVSAACGLAHLHVEIFG TQGKPAIAHRDFKSRNVLVKSNLQCCIADLGLAVMHSQGS DYLDIGNNPRVGTKRYMAPEVLDEQIRTDCFESYKWTDIW AFGLVLWEIARRTIVNGIVEDYRPPFYDVVPNDPSFEDMK KVVCVDQQTPTIPNRLAADPVLSGLAQMMRECWYPNPSAR LTALRIKKTLQKIS Description Functional site 1) chain F residue 291 type sequence R description BINDING SITE FOR RESIDUE LDN A 600 source : AC1 2) chain F residue 216 type sequence V description BINDING SITE FOR RESIDUE LDN F 600 source : AC6 3) chain F residue 227 type sequence A description BINDING SITE FOR RESIDUE LDN F 600 source : AC6 4) chain F residue 257 type sequence L description BINDING SITE FOR RESIDUE LDN F 600 source : AC6 5) chain F residue 277 type sequence T description BINDING SITE FOR RESIDUE LDN F 600 source : AC6 6) chain F residue 278 type sequence H description BINDING SITE FOR RESIDUE LDN F 600 source : AC6 7) chain F residue 280 type sequence H description BINDING SITE FOR RESIDUE LDN F 600 source : AC6 8) chain F residue 281 type sequence E description BINDING SITE FOR RESIDUE LDN F 600 source : AC6 9) chain F residue 283 type sequence G description BINDING SITE FOR RESIDUE LDN F 600 source : AC6 10) chain F residue 287 type sequence D description BINDING SITE FOR RESIDUE LDN F 600 source : AC6 11) chain F residue 334 type sequence R description BINDING SITE FOR RESIDUE LDN F 600 source : AC6 12) chain F residue 335 type sequence N description BINDING SITE FOR RESIDUE LDN F 600 source : AC6 13) chain F residue 337 type sequence L description BINDING SITE FOR RESIDUE LDN F 600 source : AC6 14) chain F residue 347 type sequence A description BINDING SITE FOR RESIDUE LDN F 600 source : AC6 15) chain F residue 330 type ACT_SITE sequence D description Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027 source Swiss-Prot : SWS_FT_FI1 16) chain F residue 208 type BINDING sequence V description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159 source Swiss-Prot : SWS_FT_FI2 17) chain F residue 229 type BINDING sequence K description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159 source Swiss-Prot : SWS_FT_FI2

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