eF-site ID 3my0-B PDB Code 3my0 Chain B click to enlarge Title Crystal structure of the ACVRL1 (ALK1) kinase domain bound to LDN-193189 Classification TRANSFERASE Compound Serine/threonine-protein kinase receptor R3 Source null (ACVL1_HUMAN) Sequence B:  QRTVARQVALVECVGKGRYGEVWRGLWHGESVAVKIFSSR DEQSWFRETEIYNTVLLRHDNILGFIASDMTTQLWLITHY HEHGSLYDFLQRQTLEPHLALRLAVSAACGLAHLHVEIFG TQGKPAIAHRDFKSRNVLVKSNLQCCIADLGLAVMHSQGS DYLDIGNNPRVGTKRYMAPEVLDEQIRTDCFESYKWTDIW AFGLVLWEIARRTIVNGIVEDYRPPFYDVVPNDPSFEDMK KVVCVDQQTPTIPNRLAADPVLSGLAQMMRECWYPNPSAR LTALRIKKTLQKISN Description Functional site 1) chain B residue 257 type sequence L description BINDING SITE FOR RESIDUE LDN B 600 source : AC2 2) chain B residue 277 type sequence T description BINDING SITE FOR RESIDUE LDN B 600 source : AC2 3) chain B residue 278 type sequence H description BINDING SITE FOR RESIDUE LDN B 600 source : AC2 4) chain B residue 279 type sequence Y description BINDING SITE FOR RESIDUE LDN B 600 source : AC2 5) chain B residue 280 type sequence H description BINDING SITE FOR RESIDUE LDN B 600 source : AC2 6) chain B residue 281 type sequence E description BINDING SITE FOR RESIDUE LDN B 600 source : AC2 7) chain B residue 282 type sequence H description BINDING SITE FOR RESIDUE LDN B 600 source : AC2 8) chain B residue 283 type sequence G description BINDING SITE FOR RESIDUE LDN B 600 source : AC2 9) chain B residue 287 type sequence D description BINDING SITE FOR RESIDUE LDN B 600 source : AC2 10) chain B residue 291 type sequence R description BINDING SITE FOR RESIDUE LDN B 600 source : AC2 11) chain B residue 334 type sequence R description BINDING SITE FOR RESIDUE LDN B 600 source : AC2 12) chain B residue 335 type sequence N description BINDING SITE FOR RESIDUE LDN B 600 source : AC2 13) chain B residue 337 type sequence L description BINDING SITE FOR RESIDUE LDN B 600 source : AC2 14) chain B residue 347 type sequence A description BINDING SITE FOR RESIDUE LDN B 600 source : AC2 15) chain B residue 348 type sequence D description BINDING SITE FOR RESIDUE LDN B 600 source : AC2 16) chain B residue 330 type ACT_SITE sequence D description Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027 source Swiss-Prot : SWS_FT_FI1 17) chain B residue 208 type BINDING sequence V description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159 source Swiss-Prot : SWS_FT_FI2 18) chain B residue 229 type BINDING sequence K description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159 source Swiss-Prot : SWS_FT_FI2

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