eF-site ID 3my0-A PDB Code 3my0 Chain A click to enlarge Title Crystal structure of the ACVRL1 (ALK1) kinase domain bound to LDN-193189 Classification TRANSFERASE Compound Serine/threonine-protein kinase receptor R3 Source Homo sapiens (Human) (ACVL1_HUMAN) Sequence A:  MQRTVARQVALVECVGKGRYGEVWRGLWHGESVAVKIFSS RDEQSWFRETEIYNTVLLRHDNILGFIASDMTSTQLWLIT HYHEHGSLYDFLQRQTLEPHLALRLAVSAACGLAHLHVEI FGTQGKPAIAHRDFKSRNVLVKSNLQCCIADLGLAVMHSQ GSDYLDIGNNPRVGTKRYMAPEVLDEQIRTDCFESYKWTD IWAFGLVLWEIARRTIVNGIVEDYRPPFYDVVPNDPSFED MKKVVCVDQQTPTIPNRLAADPVLSGLAQMMRECWYPNPS ARLTALRIKKTLQKIS Description Functional site 1) chain A residue 216 type sequence V description BINDING SITE FOR RESIDUE LDN A 600 source : AC1 2) chain A residue 227 type sequence A description BINDING SITE FOR RESIDUE LDN A 600 source : AC1 3) chain A residue 229 type sequence K description BINDING SITE FOR RESIDUE LDN A 600 source : AC1 4) chain A residue 277 type sequence T description BINDING SITE FOR RESIDUE LDN A 600 source : AC1 5) chain A residue 278 type sequence H description BINDING SITE FOR RESIDUE LDN A 600 source : AC1 6) chain A residue 279 type sequence Y description BINDING SITE FOR RESIDUE LDN A 600 source : AC1 7) chain A residue 281 type sequence E description BINDING SITE FOR RESIDUE LDN A 600 source : AC1 8) chain A residue 283 type sequence G description BINDING SITE FOR RESIDUE LDN A 600 source : AC1 9) chain A residue 287 type sequence D description BINDING SITE FOR RESIDUE LDN A 600 source : AC1 10) chain A residue 334 type sequence R description BINDING SITE FOR RESIDUE LDN A 600 source : AC1 11) chain A residue 335 type sequence N description BINDING SITE FOR RESIDUE LDN A 600 source : AC1 12) chain A residue 337 type sequence L description BINDING SITE FOR RESIDUE LDN A 600 source : AC1 13) chain A residue 291 type sequence R description BINDING SITE FOR RESIDUE LDN F 600 source : AC6 14) chain A residue 330 type ACT_SITE sequence D description Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027 source Swiss-Prot : SWS_FT_FI1 15) chain A residue 208 type BINDING sequence V description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159 source Swiss-Prot : SWS_FT_FI2 16) chain A residue 229 type BINDING sequence K description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159 source Swiss-Prot : SWS_FT_FI2 17) chain A residue 208-229 type prosite sequence VGKGRYGEVWRGLWHGESVAVK description PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. VGKGRYGEVWrGlwhges............VAVK source prosite : PS00107 18) chain A residue 326-338 type prosite sequence IAHRDFKSRNVLV description PROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. IaHrDFKsrNVLV source prosite : PS00108

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