eF-site ID 3mx2-C PDB Code 3mx2 Chain C click to enlarge Title Lassa fever virus Nucleoprotein complexed with dTTP Classification NUCLEAR PROTEIN Compound Nucleoprotein Source null (NCAP_LASSJ) Sequence C:  KSFLWTQSLRRELSGYCSNIKLQVVKDAQALLHGLDFSEV SNVQRLMRKERRDDNDLKRLRDLNQAVNNLVELKSTQQKS ILRVGTLTSDDLLILAADLEKLKSKVIRTERPLSAGVYMG NLSSQQLDQRRALLNMIGMDGVVRVWDVKNAELLNNQFGT MPSLTLACLTKQGQVDLNDAVQALTDLGLIYTAKYPNTSD LDRLTQSHPILNMIDTKSSLNISGYNFSLGAAVKAGACML DGGNMLETIKVSPQTMDGILKSILKVKKALGMFISDTPGE RNPYENILYKICLSGDGWPYIASRTSITGRAWENTVVDLG LTYSQLMTLKDAMLQLDPNAKTWMDIEGRPEDPVEIALYQ PSSGCYIHFFREPTDLKQFKQDAKYSHGIDVTDLFATQPG LTSAVIDALPRNMVITCQGSDDIRKLLESQGRKDIKLIDI ALSKTDSRKYENAVWDQYKDLCHMHTGVVVEKKKEEITPH CALMDCIMFDAAVSGGLNTSVLRAVLPRDMVFR Description Functional site 1) chain C residue 399 type sequence E description BINDING SITE FOR RESIDUE ZN C 570 source : AC5 2) chain C residue 506 type sequence C description BINDING SITE FOR RESIDUE ZN C 570 source : AC5 3) chain C residue 509 type sequence H description BINDING SITE FOR RESIDUE ZN C 570 source : AC5 4) chain C residue 529 type sequence C description BINDING SITE FOR RESIDUE ZN C 570 source : AC5 5) chain C residue 120 type sequence L description BINDING SITE FOR RESIDUE TTP C 800 source : AC6 6) chain C residue 164 type sequence W description BINDING SITE FOR RESIDUE TTP C 800 source : AC6 7) chain C residue 176 type sequence F description BINDING SITE FOR RESIDUE TTP C 800 source : AC6 8) chain C residue 177 type sequence G description BINDING SITE FOR RESIDUE TTP C 800 source : AC6 9) chain C residue 178 type sequence T description BINDING SITE FOR RESIDUE TTP C 800 source : AC6 10) chain C residue 238 type sequence S description BINDING SITE FOR RESIDUE TTP C 800 source : AC6 11) chain C residue 240 type sequence N description BINDING SITE FOR RESIDUE TTP C 800 source : AC6 12) chain C residue 241 type sequence I description BINDING SITE FOR RESIDUE TTP C 800 source : AC6 13) chain C residue 253 type sequence K description BINDING SITE FOR RESIDUE TTP C 800 source : AC6 14) chain C residue 300 type sequence R description BINDING SITE FOR RESIDUE TTP C 800 source : AC6 15) chain C residue 305 type sequence N description BINDING SITE FOR RESIDUE TTP C 800 source : AC6 16) chain C residue 309 type sequence K description BINDING SITE FOR RESIDUE TTP C 800 source : AC6 17) chain C residue 323 type sequence R description BINDING SITE FOR RESIDUE TTP C 800 source : AC6 18) chain C residue 389 type BINDING sequence D description BINDING => ECO:0000255|HAMAP-Rule:MF_04085, ECO:0000269|PubMed:21085117, ECO:0000269|PubMed:21262835 source Swiss-Prot : SWS_FT_FI1 19) chain C residue 391 type BINDING sequence E description BINDING => ECO:0000255|HAMAP-Rule:MF_04085, ECO:0000269|PubMed:21085117, ECO:0000269|PubMed:21262835 source Swiss-Prot : SWS_FT_FI1 20) chain C residue 533 type BINDING sequence D description BINDING => ECO:0000255|HAMAP-Rule:MF_04085, ECO:0000269|PubMed:21085117, ECO:0000269|PubMed:21262835 source Swiss-Prot : SWS_FT_FI1 21) chain C residue 399 type BINDING sequence E description BINDING => ECO:0000255|HAMAP-Rule:MF_04085, ECO:0000269|PubMed:21085117, ECO:0000269|PubMed:21262835, ECO:0000269|PubMed:22937163, ECO:0000269|PubMed:23615902 source Swiss-Prot : SWS_FT_FI2 22) chain C residue 506 type BINDING sequence C description BINDING => ECO:0000255|HAMAP-Rule:MF_04085, ECO:0000269|PubMed:21085117, ECO:0000269|PubMed:21262835, ECO:0000269|PubMed:22937163, ECO:0000269|PubMed:23615902 source Swiss-Prot : SWS_FT_FI2 23) chain C residue 509 type BINDING sequence H description BINDING => ECO:0000255|HAMAP-Rule:MF_04085, ECO:0000269|PubMed:21085117, ECO:0000269|PubMed:21262835, ECO:0000269|PubMed:22937163, ECO:0000269|PubMed:23615902 source Swiss-Prot : SWS_FT_FI2 24) chain C residue 529 type BINDING sequence C description BINDING => ECO:0000255|HAMAP-Rule:MF_04085, ECO:0000269|PubMed:21085117, ECO:0000269|PubMed:21262835, ECO:0000269|PubMed:22937163, ECO:0000269|PubMed:23615902 source Swiss-Prot : SWS_FT_FI2 25) chain C residue 466 type SITE sequence D description Important for exonuclease activity => ECO:0000255|HAMAP-Rule:MF_04085, ECO:0000269|PubMed:21085117 source Swiss-Prot : SWS_FT_FI3

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