eF-site ID 3mx2-ABC PDB Code 3mx2 Chain A, B, C click to enlarge Title Lassa fever virus Nucleoprotein complexed with dTTP Classification NUCLEAR PROTEIN Compound Nucleoprotein Source null (NCAP_LASSJ) Sequence A:  IKSFLWTQSLRRELSGYCSNIKLQVVKDAQALLHGLDFSE VSNVQRLMRKERRDDNDLKRLRDLNQAVNNLVELKSTQQK SILRVGTLTSDDLLILAADLEKLKSKVIRTERPLSAGVYM GNLSSQQLDQRRALLNMIGMDGVVRVWDVKNAELLNNQFG TMPSLTLACLTKQGQVDLNDAVQALTDLGLIYTAKYPNTS DLDRLTQSHPILNMIDTKKSSLNISGYNFSLGAAVKAGAC MLDGGNMLETIKVSPQTMDGILKSILKVKKALGMFISDTP GERNPYENILYKICLSGDGWPYIASRTSITGRAWENTVVD LGLTYSQLMTLKDAMLQLDPNAKTWMDIEGRPEDPVEIAL YQPSSGCYIHFFREPTDLKQFKQDAKYSHGIDVTDLFATQ PGLTSAVIDALPRNMVITCQGSDDIRKLLESQGRKDIKLI DIALSKTDSRKYENAVWDQYKDLCHMHTGVVVEKKEEITP HCALMDCIMFDAAVSGGLNTSVLRAVLPRDMVFR B:  KSFLWTQSLRRELSGYCSNIKLQVVKDAQALLHGLDFSEV SNVQRLMRKERRDDNDLKRLRDLNQAVNNLVELKSTQQKS ILRVGTLTSDDLLILAADLEKLKSKVIRTERPLSAGVYMG NLSSQQLDQRRALLNMIGMAGRDGVVRVWDVKNAELLNNQ FGTMPSLTLACLTKQGQVDLNDAVQALTDLGLIYTAKYPN TSDLDRLTQSHPILNMIDTKKSSLNISGYNFSLGAAVKAG ACMLDGGNMLETIKVSPQTMDGILKSILKVKKALGMFISD TPGERNPYENILYKICLSGDGWPYIASRTSITGRAWENTV VDLGLTYSQLMTLKDAMLQLDPNAKTWMDIEGRPEDPVEI ALYQPSSGCYIHFFREPTDLKQFKQDAKYSHGIDVTDLFA TQPGLTSAVIDALPRNMVITCQGSDDIRKLLESQGRKDIK LIDIALSKTDSRKYENAVWDQYKDLCHMHTGVVVEKKKEE ITPHCALMDCIMFDAAVSGGLNTSVLRAVLPRDMVFR C:  KSFLWTQSLRRELSGYCSNIKLQVVKDAQALLHGLDFSEV SNVQRLMRKERRDDNDLKRLRDLNQAVNNLVELKSTQQKS ILRVGTLTSDDLLILAADLEKLKSKVIRTERPLSAGVYMG NLSSQQLDQRRALLNMIGMDGVVRVWDVKNAELLNNQFGT MPSLTLACLTKQGQVDLNDAVQALTDLGLIYTAKYPNTSD LDRLTQSHPILNMIDTKSSLNISGYNFSLGAAVKAGACML DGGNMLETIKVSPQTMDGILKSILKVKKALGMFISDTPGE RNPYENILYKICLSGDGWPYIASRTSITGRAWENTVVDLG LTYSQLMTLKDAMLQLDPNAKTWMDIEGRPEDPVEIALYQ PSSGCYIHFFREPTDLKQFKQDAKYSHGIDVTDLFATQPG LTSAVIDALPRNMVITCQGSDDIRKLLESQGRKDIKLIDI ALSKTDSRKYENAVWDQYKDLCHMHTGVVVEKKKEEITPH CALMDCIMFDAAVSGGLNTSVLRAVLPRDMVFR Description Functional site 1) chain A residue 399 type sequence E description BINDING SITE FOR RESIDUE ZN A 570 source : AC1 2) chain A residue 412 type sequence H description BINDING SITE FOR RESIDUE ZN A 570 source : AC1 3) chain A residue 506 type sequence C description BINDING SITE FOR RESIDUE ZN A 570 source : AC1 4) chain A residue 509 type sequence H description BINDING SITE FOR RESIDUE ZN A 570 source : AC1 5) chain A residue 529 type sequence C description BINDING SITE FOR RESIDUE ZN A 570 source : AC1 6) chain A residue 59 type sequence R description BINDING SITE FOR RESIDUE TTP A 800 source : AC2 7) chain A residue 120 type sequence L description BINDING SITE FOR RESIDUE TTP A 800 source : AC2 8) chain A residue 164 type sequence W description BINDING SITE FOR RESIDUE TTP A 800 source : AC2 9) chain A residue 176 type sequence F description BINDING SITE FOR RESIDUE TTP A 800 source : AC2 10) chain A residue 177 type sequence G description BINDING SITE FOR RESIDUE TTP A 800 source : AC2 11) chain A residue 178 type sequence T description BINDING SITE FOR RESIDUE TTP A 800 source : AC2 12) chain A residue 238 type sequence S description BINDING SITE FOR RESIDUE TTP A 800 source : AC2 13) chain A residue 240 type sequence N description BINDING SITE FOR RESIDUE TTP A 800 source : AC2 14) chain A residue 241 type sequence I description BINDING SITE FOR RESIDUE TTP A 800 source : AC2 15) chain A residue 253 type sequence K description BINDING SITE FOR RESIDUE TTP A 800 source : AC2 16) chain A residue 300 type sequence R description BINDING SITE FOR RESIDUE TTP A 800 source : AC2 17) chain A residue 309 type sequence K description BINDING SITE FOR RESIDUE TTP A 800 source : AC2 18) chain A residue 323 type sequence R description BINDING SITE FOR RESIDUE TTP A 800 source : AC2 19) chain B residue 399 type sequence E description BINDING SITE FOR RESIDUE ZN B 570 source : AC3 20) chain B residue 506 type sequence C description BINDING SITE FOR RESIDUE ZN B 570 source : AC3 21) chain B residue 509 type sequence H description BINDING SITE FOR RESIDUE ZN B 570 source : AC3 22) chain B residue 529 type sequence C description BINDING SITE FOR RESIDUE ZN B 570 source : AC3 23) chain B residue 54 type sequence M description BINDING SITE FOR RESIDUE TTP B 800 source : AC4 24) chain B residue 59 type sequence R description BINDING SITE FOR RESIDUE TTP B 800 source : AC4 25) chain B residue 117 type sequence E description BINDING SITE FOR RESIDUE TTP B 800 source : AC4 26) chain B residue 120 type sequence L description BINDING SITE FOR RESIDUE TTP B 800 source : AC4 27) chain B residue 164 type sequence W description BINDING SITE FOR RESIDUE TTP B 800 source : AC4 28) chain B residue 176 type sequence F description BINDING SITE FOR RESIDUE TTP B 800 source : AC4 29) chain B residue 177 type sequence G description BINDING SITE FOR RESIDUE TTP B 800 source : AC4 30) chain B residue 178 type sequence T description BINDING SITE FOR RESIDUE TTP B 800 source : AC4 31) chain B residue 238 type sequence S description BINDING SITE FOR RESIDUE TTP B 800 source : AC4 32) chain B residue 239 type sequence L description BINDING SITE FOR RESIDUE TTP B 800 source : AC4 33) chain B residue 240 type sequence N description BINDING SITE FOR RESIDUE TTP B 800 source : AC4 34) chain B residue 241 type sequence I description BINDING SITE FOR RESIDUE TTP B 800 source : AC4 35) chain B residue 253 type sequence K description BINDING SITE FOR RESIDUE TTP B 800 source : AC4 36) chain B residue 305 type sequence N description BINDING SITE FOR RESIDUE TTP B 800 source : AC4 37) chain B residue 309 type sequence K description BINDING SITE FOR RESIDUE TTP B 800 source : AC4 38) chain B residue 323 type sequence R description BINDING SITE FOR RESIDUE TTP B 800 source : AC4 39) chain C residue 399 type sequence E description BINDING SITE FOR RESIDUE ZN C 570 source : AC5 40) chain C residue 506 type sequence C description BINDING SITE FOR RESIDUE ZN C 570 source : AC5 41) chain C residue 509 type sequence H description BINDING SITE FOR RESIDUE ZN C 570 source : AC5 42) chain C residue 529 type sequence C description BINDING SITE FOR RESIDUE ZN C 570 source : AC5 43) chain C residue 120 type sequence L description BINDING SITE FOR RESIDUE TTP C 800 source : AC6 44) chain C residue 164 type sequence W description BINDING SITE FOR RESIDUE TTP C 800 source : AC6 45) chain C residue 176 type sequence F description BINDING SITE FOR RESIDUE TTP C 800 source : AC6 46) chain C residue 177 type sequence G description BINDING SITE FOR RESIDUE TTP C 800 source : AC6 47) chain C residue 178 type sequence T description BINDING SITE FOR RESIDUE TTP C 800 source : AC6 48) chain C residue 238 type sequence S description BINDING SITE FOR RESIDUE TTP C 800 source : AC6 49) chain C residue 240 type sequence N description BINDING SITE FOR RESIDUE TTP C 800 source : AC6 50) chain C residue 241 type sequence I description BINDING SITE FOR RESIDUE TTP C 800 source : AC6 51) chain C residue 253 type sequence K description BINDING SITE FOR RESIDUE TTP C 800 source : AC6 52) chain C residue 300 type sequence R description BINDING SITE FOR RESIDUE TTP C 800 source : AC6 53) chain C residue 305 type sequence N description BINDING SITE FOR RESIDUE TTP C 800 source : AC6 54) chain C residue 309 type sequence K description BINDING SITE FOR RESIDUE TTP C 800 source : AC6 55) chain C residue 323 type sequence R description BINDING SITE FOR RESIDUE TTP C 800 source : AC6 56) chain A residue 389 type BINDING sequence D description BINDING => ECO:0000255|HAMAP-Rule:MF_04085, ECO:0000269|PubMed:21085117, ECO:0000269|PubMed:21262835 source Swiss-Prot : SWS_FT_FI1 57) chain A residue 391 type BINDING sequence E description BINDING => ECO:0000255|HAMAP-Rule:MF_04085, ECO:0000269|PubMed:21085117, ECO:0000269|PubMed:21262835 source Swiss-Prot : SWS_FT_FI1 58) chain A residue 533 type BINDING sequence D description BINDING => ECO:0000255|HAMAP-Rule:MF_04085, ECO:0000269|PubMed:21085117, ECO:0000269|PubMed:21262835 source Swiss-Prot : SWS_FT_FI1 59) chain B residue 389 type BINDING sequence D description BINDING => ECO:0000255|HAMAP-Rule:MF_04085, ECO:0000269|PubMed:21085117, ECO:0000269|PubMed:21262835 source Swiss-Prot : SWS_FT_FI1 60) chain B residue 391 type BINDING sequence E description BINDING => ECO:0000255|HAMAP-Rule:MF_04085, ECO:0000269|PubMed:21085117, ECO:0000269|PubMed:21262835 source Swiss-Prot : SWS_FT_FI1 61) chain B residue 533 type BINDING sequence D description BINDING => ECO:0000255|HAMAP-Rule:MF_04085, ECO:0000269|PubMed:21085117, ECO:0000269|PubMed:21262835 source Swiss-Prot : SWS_FT_FI1 62) chain C residue 389 type BINDING sequence D description BINDING => ECO:0000255|HAMAP-Rule:MF_04085, ECO:0000269|PubMed:21085117, ECO:0000269|PubMed:21262835 source Swiss-Prot : SWS_FT_FI1 63) chain C residue 391 type BINDING sequence E description BINDING => ECO:0000255|HAMAP-Rule:MF_04085, ECO:0000269|PubMed:21085117, ECO:0000269|PubMed:21262835 source Swiss-Prot : SWS_FT_FI1 64) chain C residue 533 type BINDING sequence D description BINDING => ECO:0000255|HAMAP-Rule:MF_04085, ECO:0000269|PubMed:21085117, ECO:0000269|PubMed:21262835 source Swiss-Prot : SWS_FT_FI1 65) chain A residue 399 type BINDING sequence E description BINDING => ECO:0000255|HAMAP-Rule:MF_04085, ECO:0000269|PubMed:21085117, ECO:0000269|PubMed:21262835, ECO:0000269|PubMed:22937163, ECO:0000269|PubMed:23615902 source Swiss-Prot : SWS_FT_FI2 66) chain A residue 506 type BINDING sequence C description BINDING => ECO:0000255|HAMAP-Rule:MF_04085, ECO:0000269|PubMed:21085117, ECO:0000269|PubMed:21262835, ECO:0000269|PubMed:22937163, ECO:0000269|PubMed:23615902 source Swiss-Prot : SWS_FT_FI2 67) chain A residue 509 type BINDING sequence H description BINDING => ECO:0000255|HAMAP-Rule:MF_04085, ECO:0000269|PubMed:21085117, ECO:0000269|PubMed:21262835, ECO:0000269|PubMed:22937163, ECO:0000269|PubMed:23615902 source Swiss-Prot : SWS_FT_FI2 68) chain A residue 529 type BINDING sequence C description BINDING => ECO:0000255|HAMAP-Rule:MF_04085, ECO:0000269|PubMed:21085117, ECO:0000269|PubMed:21262835, ECO:0000269|PubMed:22937163, ECO:0000269|PubMed:23615902 source Swiss-Prot : SWS_FT_FI2 69) chain B residue 399 type BINDING sequence E description BINDING => ECO:0000255|HAMAP-Rule:MF_04085, ECO:0000269|PubMed:21085117, ECO:0000269|PubMed:21262835, ECO:0000269|PubMed:22937163, ECO:0000269|PubMed:23615902 source Swiss-Prot : SWS_FT_FI2 70) chain B residue 506 type BINDING sequence C description BINDING => ECO:0000255|HAMAP-Rule:MF_04085, ECO:0000269|PubMed:21085117, ECO:0000269|PubMed:21262835, ECO:0000269|PubMed:22937163, ECO:0000269|PubMed:23615902 source Swiss-Prot : SWS_FT_FI2 71) chain B residue 509 type BINDING sequence H description BINDING => ECO:0000255|HAMAP-Rule:MF_04085, ECO:0000269|PubMed:21085117, ECO:0000269|PubMed:21262835, ECO:0000269|PubMed:22937163, ECO:0000269|PubMed:23615902 source Swiss-Prot : SWS_FT_FI2 72) chain B residue 529 type BINDING sequence C description BINDING => ECO:0000255|HAMAP-Rule:MF_04085, ECO:0000269|PubMed:21085117, ECO:0000269|PubMed:21262835, ECO:0000269|PubMed:22937163, ECO:0000269|PubMed:23615902 source Swiss-Prot : SWS_FT_FI2 73) chain C residue 399 type BINDING sequence E description BINDING => ECO:0000255|HAMAP-Rule:MF_04085, ECO:0000269|PubMed:21085117, ECO:0000269|PubMed:21262835, ECO:0000269|PubMed:22937163, ECO:0000269|PubMed:23615902 source Swiss-Prot : SWS_FT_FI2 74) chain C residue 506 type BINDING sequence C description BINDING => ECO:0000255|HAMAP-Rule:MF_04085, ECO:0000269|PubMed:21085117, ECO:0000269|PubMed:21262835, ECO:0000269|PubMed:22937163, ECO:0000269|PubMed:23615902 source Swiss-Prot : SWS_FT_FI2 75) chain C residue 509 type BINDING sequence H description BINDING => ECO:0000255|HAMAP-Rule:MF_04085, ECO:0000269|PubMed:21085117, ECO:0000269|PubMed:21262835, ECO:0000269|PubMed:22937163, ECO:0000269|PubMed:23615902 source Swiss-Prot : SWS_FT_FI2 76) chain C residue 529 type BINDING sequence C description BINDING => ECO:0000255|HAMAP-Rule:MF_04085, ECO:0000269|PubMed:21085117, ECO:0000269|PubMed:21262835, ECO:0000269|PubMed:22937163, ECO:0000269|PubMed:23615902 source Swiss-Prot : SWS_FT_FI2 77) chain A residue 466 type SITE sequence D description Important for exonuclease activity => ECO:0000255|HAMAP-Rule:MF_04085, ECO:0000269|PubMed:21085117 source Swiss-Prot : SWS_FT_FI3 78) chain B residue 466 type SITE sequence D description Important for exonuclease activity => ECO:0000255|HAMAP-Rule:MF_04085, ECO:0000269|PubMed:21085117 source Swiss-Prot : SWS_FT_FI3 79) chain C residue 466 type SITE sequence D description Important for exonuclease activity => ECO:0000255|HAMAP-Rule:MF_04085, ECO:0000269|PubMed:21085117 source Swiss-Prot : SWS_FT_FI3

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