eF-site ID 3mwt-C
PDB Code 3mwt
Chain C

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Title Crystal structure of Lassa fever virus nucleoprotein in complex with Mn2+
Classification NUCLEAR PROTEIN
Compound Nucleoprotein
Source Lassa virus (strain Mouse/Sierra Leone/Josiah/1976) (LASV) (NCAP_LASSJ)
Sequence C:  KSFLWTQSLRRELSGYCSNIKLQVVKDAQALLHGLDFSEV
SNVQRLMRKERRDDNDLKRLRDLNQAVNNLVELKSTQQKS
ILRVGTLTSDDLLILAADLEKLKSKVIRTERPLSAGVYMG
NLSSQQLDQRRALLNMIGMGVVRVWDVKNAELLNNQFGTM
PSLTLACLTKQGQVDLNDAVQALTDLGLIYTAKYPNTSDL
DRLTQSHPILNMIDSSLNISGYNFSLGAAVKAGACMLNML
ETIKVSPQTMDGILKSILKVKKALGMFISDTPGERNPYEN
ILYKICLSGDGWPYIASRTSITGRAWENTVVDGLTYSQLM
TLKDAMLQLDPNAKTWMDIEGRPEDPVEIALYQPSSGCYI
HFFREPTDLKQFKQDAKYSHGIDVTDLFATQPGLTSAVID
ALPRNMVITCQGSDDIRKLLESQGRKDIKLIDIALSKTDS
RKYENAVWDQYKDLCHMHTGVVVEKEEITPHCALMDCIMF
DAAVSGGLLRAVLPRDMVFR
Description


Functional site
1) chain C
residue 389
type
sequence D
description BINDING SITE FOR RESIDUE MN C 680
source : AC5
2) chain C
residue 391
type
sequence E
description BINDING SITE FOR RESIDUE MN C 680
source : AC5
3) chain C
residue 533
type
sequence D
description BINDING SITE FOR RESIDUE MN C 680
source : AC5
4) chain C
residue 399
type
sequence E
description BINDING SITE FOR RESIDUE ZN C 690
source : AC6
5) chain C
residue 506
type
sequence C
description BINDING SITE FOR RESIDUE ZN C 690
source : AC6
6) chain C
residue 509
type
sequence H
description BINDING SITE FOR RESIDUE ZN C 690
source : AC6
7) chain C
residue 529
type
sequence C
description BINDING SITE FOR RESIDUE ZN C 690
source : AC6
8) chain C
residue 389
type BINDING
sequence D
description BINDING => ECO:0000255|HAMAP-Rule:MF_04085, ECO:0000269|PubMed:21085117, ECO:0000269|PubMed:21262835
source Swiss-Prot : SWS_FT_FI1
9) chain C
residue 391
type BINDING
sequence E
description BINDING => ECO:0000255|HAMAP-Rule:MF_04085, ECO:0000269|PubMed:21085117, ECO:0000269|PubMed:21262835
source Swiss-Prot : SWS_FT_FI1
10) chain C
residue 533
type BINDING
sequence D
description BINDING => ECO:0000255|HAMAP-Rule:MF_04085, ECO:0000269|PubMed:21085117, ECO:0000269|PubMed:21262835
source Swiss-Prot : SWS_FT_FI1
11) chain C
residue 506
type BINDING
sequence C
description BINDING => ECO:0000255|HAMAP-Rule:MF_04085, ECO:0000269|PubMed:21085117, ECO:0000269|PubMed:21262835, ECO:0000269|PubMed:22937163, ECO:0000269|PubMed:23615902
source Swiss-Prot : SWS_FT_FI2
12) chain C
residue 509
type BINDING
sequence H
description BINDING => ECO:0000255|HAMAP-Rule:MF_04085, ECO:0000269|PubMed:21085117, ECO:0000269|PubMed:21262835, ECO:0000269|PubMed:22937163, ECO:0000269|PubMed:23615902
source Swiss-Prot : SWS_FT_FI2
13) chain C
residue 529
type BINDING
sequence C
description BINDING => ECO:0000255|HAMAP-Rule:MF_04085, ECO:0000269|PubMed:21085117, ECO:0000269|PubMed:21262835, ECO:0000269|PubMed:22937163, ECO:0000269|PubMed:23615902
source Swiss-Prot : SWS_FT_FI2
14) chain C
residue 399
type BINDING
sequence E
description BINDING => ECO:0000255|HAMAP-Rule:MF_04085, ECO:0000269|PubMed:21085117, ECO:0000269|PubMed:21262835, ECO:0000269|PubMed:22937163, ECO:0000269|PubMed:23615902
source Swiss-Prot : SWS_FT_FI2
15) chain C
residue 466
type SITE
sequence D
description Important for exonuclease activity => ECO:0000255|HAMAP-Rule:MF_04085, ECO:0000269|PubMed:21085117
source Swiss-Prot : SWS_FT_FI3

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