eF-site ID 3mwt-B PDB Code 3mwt Chain B click to enlarge Title Crystal structure of Lassa fever virus nucleoprotein in complex with Mn2+ Classification NUCLEAR PROTEIN Compound Nucleoprotein Source Lassa virus (strain Mouse/Sierra Leone/Josiah/1976) (LASV) (NCAP_LASSJ) Sequence B:  KSFLWTQSLRRELSGYCSNIKLQVVKDAQALLHGLDFSEV SNVQRLMRKERRDDNDLKRLRDLNQAVNNLVELKSTQQKS ILRVGTLTSDDLLILAADLEKLKSKVIRTERPLSAGVYMG NLSSQQLDQRRALLNMIGMSDGVVRVWDVKNAELLNNQFG TMPSLTLACLTKQGQVDLNDAVQALTDLGLIYTAKYPNTS DLDRLTQSHPILNMIDTKSSLNISGYNFSLGAAVKAGACM LDGGNMLETIKVSPQTMDGILKSILKVKKALGMFISDTPG ERNPYENILYKICLSGDGWPYIASRTSITGRAWENTVVDG LTYSQLMTLKDAMLQLDPNAKTWMDIEGRPEDPVEIALYQ PSSGCYIHFFREPTDLKQFKQDAKYSHGIDVTDLFATQPG LTSAVIDALPRNMVITCQGSDDIRKLLESQGRKDIKLIDI ALSKTDSRKYENAVWDQYKDLCHMHTGVVVEKKEEITPHC ALMDCIMFDAAVSGGLNTSVLRAVLPRDMVFR Description Functional site 1) chain B residue 389 type sequence D description BINDING SITE FOR RESIDUE MN B 680 source : AC3 2) chain B residue 391 type sequence E description BINDING SITE FOR RESIDUE MN B 680 source : AC3 3) chain B residue 533 type sequence D description BINDING SITE FOR RESIDUE MN B 680 source : AC3 4) chain B residue 399 type sequence E description BINDING SITE FOR RESIDUE ZN B 690 source : AC4 5) chain B residue 412 type sequence H description BINDING SITE FOR RESIDUE ZN B 690 source : AC4 6) chain B residue 506 type sequence C description BINDING SITE FOR RESIDUE ZN B 690 source : AC4 7) chain B residue 509 type sequence H description BINDING SITE FOR RESIDUE ZN B 690 source : AC4 8) chain B residue 529 type sequence C description BINDING SITE FOR RESIDUE ZN B 690 source : AC4 9) chain B residue 389 type BINDING sequence D description BINDING => ECO:0000255|HAMAP-Rule:MF_04085, ECO:0000269|PubMed:21085117, ECO:0000269|PubMed:21262835 source Swiss-Prot : SWS_FT_FI1 10) chain B residue 391 type BINDING sequence E description BINDING => ECO:0000255|HAMAP-Rule:MF_04085, ECO:0000269|PubMed:21085117, ECO:0000269|PubMed:21262835 source Swiss-Prot : SWS_FT_FI1 11) chain B residue 533 type BINDING sequence D description BINDING => ECO:0000255|HAMAP-Rule:MF_04085, ECO:0000269|PubMed:21085117, ECO:0000269|PubMed:21262835 source Swiss-Prot : SWS_FT_FI1 12) chain B residue 399 type BINDING sequence E description BINDING => ECO:0000255|HAMAP-Rule:MF_04085, ECO:0000269|PubMed:21085117, ECO:0000269|PubMed:21262835, ECO:0000269|PubMed:22937163, ECO:0000269|PubMed:23615902 source Swiss-Prot : SWS_FT_FI2 13) chain B residue 506 type BINDING sequence C description BINDING => ECO:0000255|HAMAP-Rule:MF_04085, ECO:0000269|PubMed:21085117, ECO:0000269|PubMed:21262835, ECO:0000269|PubMed:22937163, ECO:0000269|PubMed:23615902 source Swiss-Prot : SWS_FT_FI2 14) chain B residue 509 type BINDING sequence H description BINDING => ECO:0000255|HAMAP-Rule:MF_04085, ECO:0000269|PubMed:21085117, ECO:0000269|PubMed:21262835, ECO:0000269|PubMed:22937163, ECO:0000269|PubMed:23615902 source Swiss-Prot : SWS_FT_FI2 15) chain B residue 529 type BINDING sequence C description BINDING => ECO:0000255|HAMAP-Rule:MF_04085, ECO:0000269|PubMed:21085117, ECO:0000269|PubMed:21262835, ECO:0000269|PubMed:22937163, ECO:0000269|PubMed:23615902 source Swiss-Prot : SWS_FT_FI2 16) chain B residue 466 type SITE sequence D description Important for exonuclease activity => ECO:0000255|HAMAP-Rule:MF_04085, ECO:0000269|PubMed:21085117 source Swiss-Prot : SWS_FT_FI3

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