eF-site ID 3mwt-ABC
PDB Code 3mwt
Chain A, B, C

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Title Crystal structure of Lassa fever virus nucleoprotein in complex with Mn2+
Classification NUCLEAR PROTEIN
Compound Nucleoprotein
Source Lassa virus (strain Mouse/Sierra Leone/Josiah/1976) (LASV) (NCAP_LASSJ)
Sequence A:  IKSFLWTQSLRRELSGYCSNIKLQVVKDAQALLHGLDFSE
VSNVQRLMRKERRDDNDLKRLRDLNQAVNNLVELKSTQQK
SILRVGTLTSDDLLILAADLEKLKSKVIRTERPLSAGVYM
GNLSSQQLDQRRALLNMIGMDGVVRVWDVKNAELLNNQFG
TMPSLTLACLTKQGQVDLNDAVQALTDLGLIYTAKYPNTS
DLDRLTQSHPILNMIDTKKSSLNISGYNFSLGAAVKAGAC
MLDGGNMLETIKVSPQTMDGILKSILKVKKALGMFISDTP
GERNPYENILYKICLSGDGWPYIASRTSITGRAWENTVVD
LGLTYSQLMTLKDAMLQLDPNAKTWMDIEGRPEDPVEIAL
YQPSSGCYIHFFREPTDLKQFKQDAKYSHGIDVTDLFATQ
PGLTSAVIDALPRNMVITCQGSDDIRKLLESQGRKDIKLI
DIALSKTDSRKYENAVWDQYKDLCHMHTGVVVEKKEEITP
HCALMDCIMFDAAVSGGLTSVLRAVLPRDMVFR
B:  KSFLWTQSLRRELSGYCSNIKLQVVKDAQALLHGLDFSEV
SNVQRLMRKERRDDNDLKRLRDLNQAVNNLVELKSTQQKS
ILRVGTLTSDDLLILAADLEKLKSKVIRTERPLSAGVYMG
NLSSQQLDQRRALLNMIGMSDGVVRVWDVKNAELLNNQFG
TMPSLTLACLTKQGQVDLNDAVQALTDLGLIYTAKYPNTS
DLDRLTQSHPILNMIDTKSSLNISGYNFSLGAAVKAGACM
LDGGNMLETIKVSPQTMDGILKSILKVKKALGMFISDTPG
ERNPYENILYKICLSGDGWPYIASRTSITGRAWENTVVDG
LTYSQLMTLKDAMLQLDPNAKTWMDIEGRPEDPVEIALYQ
PSSGCYIHFFREPTDLKQFKQDAKYSHGIDVTDLFATQPG
LTSAVIDALPRNMVITCQGSDDIRKLLESQGRKDIKLIDI
ALSKTDSRKYENAVWDQYKDLCHMHTGVVVEKKEEITPHC
ALMDCIMFDAAVSGGLNTSVLRAVLPRDMVFR
C:  KSFLWTQSLRRELSGYCSNIKLQVVKDAQALLHGLDFSEV
SNVQRLMRKERRDDNDLKRLRDLNQAVNNLVELKSTQQKS
ILRVGTLTSDDLLILAADLEKLKSKVIRTERPLSAGVYMG
NLSSQQLDQRRALLNMIGMGVVRVWDVKNAELLNNQFGTM
PSLTLACLTKQGQVDLNDAVQALTDLGLIYTAKYPNTSDL
DRLTQSHPILNMIDSSLNISGYNFSLGAAVKAGACMLNML
ETIKVSPQTMDGILKSILKVKKALGMFISDTPGERNPYEN
ILYKICLSGDGWPYIASRTSITGRAWENTVVDGLTYSQLM
TLKDAMLQLDPNAKTWMDIEGRPEDPVEIALYQPSSGCYI
HFFREPTDLKQFKQDAKYSHGIDVTDLFATQPGLTSAVID
ALPRNMVITCQGSDDIRKLLESQGRKDIKLIDIALSKTDS
RKYENAVWDQYKDLCHMHTGVVVEKEEITPHCALMDCIMF
DAAVSGGLLRAVLPRDMVFR
Description


Functional site
1) chain A
residue 389
type
sequence D
description BINDING SITE FOR RESIDUE MN A 680
source : AC1
2) chain A
residue 391
type
sequence E
description BINDING SITE FOR RESIDUE MN A 680
source : AC1
3) chain A
residue 533
type
sequence D
description BINDING SITE FOR RESIDUE MN A 680
source : AC1
4) chain A
residue 399
type
sequence E
description BINDING SITE FOR RESIDUE ZN A 690
source : AC2
5) chain A
residue 412
type
sequence H
description BINDING SITE FOR RESIDUE ZN A 690
source : AC2
6) chain A
residue 506
type
sequence C
description BINDING SITE FOR RESIDUE ZN A 690
source : AC2
7) chain A
residue 509
type
sequence H
description BINDING SITE FOR RESIDUE ZN A 690
source : AC2
8) chain A
residue 529
type
sequence C
description BINDING SITE FOR RESIDUE ZN A 690
source : AC2
9) chain B
residue 389
type
sequence D
description BINDING SITE FOR RESIDUE MN B 680
source : AC3
10) chain B
residue 391
type
sequence E
description BINDING SITE FOR RESIDUE MN B 680
source : AC3
11) chain B
residue 533
type
sequence D
description BINDING SITE FOR RESIDUE MN B 680
source : AC3
12) chain B
residue 399
type
sequence E
description BINDING SITE FOR RESIDUE ZN B 690
source : AC4
13) chain B
residue 412
type
sequence H
description BINDING SITE FOR RESIDUE ZN B 690
source : AC4
14) chain B
residue 506
type
sequence C
description BINDING SITE FOR RESIDUE ZN B 690
source : AC4
15) chain B
residue 509
type
sequence H
description BINDING SITE FOR RESIDUE ZN B 690
source : AC4
16) chain B
residue 529
type
sequence C
description BINDING SITE FOR RESIDUE ZN B 690
source : AC4
17) chain C
residue 389
type
sequence D
description BINDING SITE FOR RESIDUE MN C 680
source : AC5
18) chain C
residue 391
type
sequence E
description BINDING SITE FOR RESIDUE MN C 680
source : AC5
19) chain C
residue 533
type
sequence D
description BINDING SITE FOR RESIDUE MN C 680
source : AC5
20) chain C
residue 399
type
sequence E
description BINDING SITE FOR RESIDUE ZN C 690
source : AC6
21) chain C
residue 506
type
sequence C
description BINDING SITE FOR RESIDUE ZN C 690
source : AC6
22) chain C
residue 509
type
sequence H
description BINDING SITE FOR RESIDUE ZN C 690
source : AC6
23) chain C
residue 529
type
sequence C
description BINDING SITE FOR RESIDUE ZN C 690
source : AC6
24) chain A
residue 389
type BINDING
sequence D
description BINDING => ECO:0000255|HAMAP-Rule:MF_04085, ECO:0000269|PubMed:21085117, ECO:0000269|PubMed:21262835
source Swiss-Prot : SWS_FT_FI1
25) chain A
residue 391
type BINDING
sequence E
description BINDING => ECO:0000255|HAMAP-Rule:MF_04085, ECO:0000269|PubMed:21085117, ECO:0000269|PubMed:21262835
source Swiss-Prot : SWS_FT_FI1
26) chain A
residue 533
type BINDING
sequence D
description BINDING => ECO:0000255|HAMAP-Rule:MF_04085, ECO:0000269|PubMed:21085117, ECO:0000269|PubMed:21262835
source Swiss-Prot : SWS_FT_FI1
27) chain B
residue 389
type BINDING
sequence D
description BINDING => ECO:0000255|HAMAP-Rule:MF_04085, ECO:0000269|PubMed:21085117, ECO:0000269|PubMed:21262835
source Swiss-Prot : SWS_FT_FI1
28) chain B
residue 391
type BINDING
sequence E
description BINDING => ECO:0000255|HAMAP-Rule:MF_04085, ECO:0000269|PubMed:21085117, ECO:0000269|PubMed:21262835
source Swiss-Prot : SWS_FT_FI1
29) chain B
residue 533
type BINDING
sequence D
description BINDING => ECO:0000255|HAMAP-Rule:MF_04085, ECO:0000269|PubMed:21085117, ECO:0000269|PubMed:21262835
source Swiss-Prot : SWS_FT_FI1
30) chain C
residue 389
type BINDING
sequence D
description BINDING => ECO:0000255|HAMAP-Rule:MF_04085, ECO:0000269|PubMed:21085117, ECO:0000269|PubMed:21262835
source Swiss-Prot : SWS_FT_FI1
31) chain C
residue 391
type BINDING
sequence E
description BINDING => ECO:0000255|HAMAP-Rule:MF_04085, ECO:0000269|PubMed:21085117, ECO:0000269|PubMed:21262835
source Swiss-Prot : SWS_FT_FI1
32) chain C
residue 533
type BINDING
sequence D
description BINDING => ECO:0000255|HAMAP-Rule:MF_04085, ECO:0000269|PubMed:21085117, ECO:0000269|PubMed:21262835
source Swiss-Prot : SWS_FT_FI1
33) chain A
residue 399
type BINDING
sequence E
description BINDING => ECO:0000255|HAMAP-Rule:MF_04085, ECO:0000269|PubMed:21085117, ECO:0000269|PubMed:21262835, ECO:0000269|PubMed:22937163, ECO:0000269|PubMed:23615902
source Swiss-Prot : SWS_FT_FI2
34) chain C
residue 506
type BINDING
sequence C
description BINDING => ECO:0000255|HAMAP-Rule:MF_04085, ECO:0000269|PubMed:21085117, ECO:0000269|PubMed:21262835, ECO:0000269|PubMed:22937163, ECO:0000269|PubMed:23615902
source Swiss-Prot : SWS_FT_FI2
35) chain C
residue 509
type BINDING
sequence H
description BINDING => ECO:0000255|HAMAP-Rule:MF_04085, ECO:0000269|PubMed:21085117, ECO:0000269|PubMed:21262835, ECO:0000269|PubMed:22937163, ECO:0000269|PubMed:23615902
source Swiss-Prot : SWS_FT_FI2
36) chain C
residue 529
type BINDING
sequence C
description BINDING => ECO:0000255|HAMAP-Rule:MF_04085, ECO:0000269|PubMed:21085117, ECO:0000269|PubMed:21262835, ECO:0000269|PubMed:22937163, ECO:0000269|PubMed:23615902
source Swiss-Prot : SWS_FT_FI2
37) chain A
residue 506
type BINDING
sequence C
description BINDING => ECO:0000255|HAMAP-Rule:MF_04085, ECO:0000269|PubMed:21085117, ECO:0000269|PubMed:21262835, ECO:0000269|PubMed:22937163, ECO:0000269|PubMed:23615902
source Swiss-Prot : SWS_FT_FI2
38) chain A
residue 509
type BINDING
sequence H
description BINDING => ECO:0000255|HAMAP-Rule:MF_04085, ECO:0000269|PubMed:21085117, ECO:0000269|PubMed:21262835, ECO:0000269|PubMed:22937163, ECO:0000269|PubMed:23615902
source Swiss-Prot : SWS_FT_FI2
39) chain A
residue 529
type BINDING
sequence C
description BINDING => ECO:0000255|HAMAP-Rule:MF_04085, ECO:0000269|PubMed:21085117, ECO:0000269|PubMed:21262835, ECO:0000269|PubMed:22937163, ECO:0000269|PubMed:23615902
source Swiss-Prot : SWS_FT_FI2
40) chain B
residue 399
type BINDING
sequence E
description BINDING => ECO:0000255|HAMAP-Rule:MF_04085, ECO:0000269|PubMed:21085117, ECO:0000269|PubMed:21262835, ECO:0000269|PubMed:22937163, ECO:0000269|PubMed:23615902
source Swiss-Prot : SWS_FT_FI2
41) chain B
residue 506
type BINDING
sequence C
description BINDING => ECO:0000255|HAMAP-Rule:MF_04085, ECO:0000269|PubMed:21085117, ECO:0000269|PubMed:21262835, ECO:0000269|PubMed:22937163, ECO:0000269|PubMed:23615902
source Swiss-Prot : SWS_FT_FI2
42) chain B
residue 509
type BINDING
sequence H
description BINDING => ECO:0000255|HAMAP-Rule:MF_04085, ECO:0000269|PubMed:21085117, ECO:0000269|PubMed:21262835, ECO:0000269|PubMed:22937163, ECO:0000269|PubMed:23615902
source Swiss-Prot : SWS_FT_FI2
43) chain B
residue 529
type BINDING
sequence C
description BINDING => ECO:0000255|HAMAP-Rule:MF_04085, ECO:0000269|PubMed:21085117, ECO:0000269|PubMed:21262835, ECO:0000269|PubMed:22937163, ECO:0000269|PubMed:23615902
source Swiss-Prot : SWS_FT_FI2
44) chain C
residue 399
type BINDING
sequence E
description BINDING => ECO:0000255|HAMAP-Rule:MF_04085, ECO:0000269|PubMed:21085117, ECO:0000269|PubMed:21262835, ECO:0000269|PubMed:22937163, ECO:0000269|PubMed:23615902
source Swiss-Prot : SWS_FT_FI2
45) chain A
residue 466
type SITE
sequence D
description Important for exonuclease activity => ECO:0000255|HAMAP-Rule:MF_04085, ECO:0000269|PubMed:21085117
source Swiss-Prot : SWS_FT_FI3
46) chain B
residue 466
type SITE
sequence D
description Important for exonuclease activity => ECO:0000255|HAMAP-Rule:MF_04085, ECO:0000269|PubMed:21085117
source Swiss-Prot : SWS_FT_FI3
47) chain C
residue 466
type SITE
sequence D
description Important for exonuclease activity => ECO:0000255|HAMAP-Rule:MF_04085, ECO:0000269|PubMed:21085117
source Swiss-Prot : SWS_FT_FI3

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