eF-site ID 3mwt-A PDB Code 3mwt Chain A click to enlarge Title Crystal structure of Lassa fever virus nucleoprotein in complex with Mn2+ Classification NUCLEAR PROTEIN Compound Nucleoprotein Source null (NCAP_LASSJ) Sequence A:  IKSFLWTQSLRRELSGYCSNIKLQVVKDAQALLHGLDFSE VSNVQRLMRKERRDDNDLKRLRDLNQAVNNLVELKSTQQK SILRVGTLTSDDLLILAADLEKLKSKVIRTERPLSAGVYM GNLSSQQLDQRRALLNMIGMDGVVRVWDVKNAELLNNQFG TMPSLTLACLTKQGQVDLNDAVQALTDLGLIYTAKYPNTS DLDRLTQSHPILNMIDTKKSSLNISGYNFSLGAAVKAGAC MLDGGNMLETIKVSPQTMDGILKSILKVKKALGMFISDTP GERNPYENILYKICLSGDGWPYIASRTSITGRAWENTVVD LGLTYSQLMTLKDAMLQLDPNAKTWMDIEGRPEDPVEIAL YQPSSGCYIHFFREPTDLKQFKQDAKYSHGIDVTDLFATQ PGLTSAVIDALPRNMVITCQGSDDIRKLLESQGRKDIKLI DIALSKTDSRKYENAVWDQYKDLCHMHTGVVVEKKEEITP HCALMDCIMFDAAVSGGLTSVLRAVLPRDMVFR Description Functional site 1) chain A residue 389 type sequence D description BINDING SITE FOR RESIDUE MN A 680 source : AC1 2) chain A residue 391 type sequence E description BINDING SITE FOR RESIDUE MN A 680 source : AC1 3) chain A residue 533 type sequence D description BINDING SITE FOR RESIDUE MN A 680 source : AC1 4) chain A residue 399 type sequence E description BINDING SITE FOR RESIDUE ZN A 690 source : AC2 5) chain A residue 412 type sequence H description BINDING SITE FOR RESIDUE ZN A 690 source : AC2 6) chain A residue 506 type sequence C description BINDING SITE FOR RESIDUE ZN A 690 source : AC2 7) chain A residue 509 type sequence H description BINDING SITE FOR RESIDUE ZN A 690 source : AC2 8) chain A residue 529 type sequence C description BINDING SITE FOR RESIDUE ZN A 690 source : AC2 9) chain A residue 509 type BINDING sequence H description BINDING => ECO:0000255|HAMAP-Rule:MF_04085, ECO:0000269|PubMed:21085117, ECO:0000269|PubMed:21262835, ECO:0000269|PubMed:22937163, ECO:0000269|PubMed:23615902 source Swiss-Prot : SWS_FT_FI2 10) chain A residue 529 type BINDING sequence C description BINDING => ECO:0000255|HAMAP-Rule:MF_04085, ECO:0000269|PubMed:21085117, ECO:0000269|PubMed:21262835, ECO:0000269|PubMed:22937163, ECO:0000269|PubMed:23615902 source Swiss-Prot : SWS_FT_FI2 11) chain A residue 399 type BINDING sequence E description BINDING => ECO:0000255|HAMAP-Rule:MF_04085, ECO:0000269|PubMed:21085117, ECO:0000269|PubMed:21262835, ECO:0000269|PubMed:22937163, ECO:0000269|PubMed:23615902 source Swiss-Prot : SWS_FT_FI2 12) chain A residue 506 type BINDING sequence C description BINDING => ECO:0000255|HAMAP-Rule:MF_04085, ECO:0000269|PubMed:21085117, ECO:0000269|PubMed:21262835, ECO:0000269|PubMed:22937163, ECO:0000269|PubMed:23615902 source Swiss-Prot : SWS_FT_FI2 13) chain A residue 466 type SITE sequence D description Important for exonuclease activity => ECO:0000255|HAMAP-Rule:MF_04085, ECO:0000269|PubMed:21085117 source Swiss-Prot : SWS_FT_FI3 14) chain A residue 389 type BINDING sequence D description BINDING => ECO:0000255|HAMAP-Rule:MF_04085, ECO:0000269|PubMed:21085117, ECO:0000269|PubMed:21262835 source Swiss-Prot : SWS_FT_FI1 15) chain A residue 391 type BINDING sequence E description BINDING => ECO:0000255|HAMAP-Rule:MF_04085, ECO:0000269|PubMed:21085117, ECO:0000269|PubMed:21262835 source Swiss-Prot : SWS_FT_FI1 16) chain A residue 533 type BINDING sequence D description BINDING => ECO:0000255|HAMAP-Rule:MF_04085, ECO:0000269|PubMed:21085117, ECO:0000269|PubMed:21262835 source Swiss-Prot : SWS_FT_FI1

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