eF-site ID 3mwp-ABC
PDB Code 3mwp
Chain A, B, C

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Title Nucleoprotein structure of lassa fever virus
Classification NUCLEAR PROTEIN
Compound Nucleoprotein
Source Lassa virus (strain Mouse/Sierra Leone/Josiah/1976) (LASV) (NCAP_LASSJ)
Sequence A:  IKSFLWTQSLRRELSGYCSNIKLQVVKDAQALLHGLDFSE
VSNVQRLMRKERRDDNDLKRLRDLNQAVNNLVELKSTQQK
SILRVGTLTSDDLLILAADLEKLKSKVIRTERPLSAGVYM
GNLSSQQLDQRRALLNMIGMDGVVRVWDVKNAELLNNQFG
TMPSLTLACLTKQGQVDLNDAVQALTDLGLIYTAKYPNTS
DLDRLTQSHPILNMIDTKKSSLNISGYNFSLGAAVKAGAC
MLDGGNMLETIKVSPQTMDGILKSILKVKKALGMFISDTP
GERNPYENILYKICLSGDGWPYIASRTSITGRAWENTVVD
LGLTYSQLMTLKDAMLQLDPNAKTWMDIEGRPEDPVEIAL
YQPSSGCYIHFFREPTDLKQFKQDAKYSHGIDVTDLFATQ
PGLTSAVIDALPRNMVITCQGSDDIRKLLESQGRKDIKLI
DIALSKTDSRKYENAVWDQYKDLCHMHTGVVVEKKEEITP
HCALMDCIMFDAAVSGGLSVLRAVLPRDMVFR
B:  KSFLWTQSLRRELSGYCSNIKLQVVKDAQALLHGLDFSEV
SNVQRLMRKERRDDNDLKRLRDLNQAVNNLVELKSTQQKS
ILRVGTLTSDDLLILAADLEKLKSKVIRTERPLSAGVYMG
NLSSQQLDQRRALLNMIGMSDGVVRVWDVKNAELLNNQFG
TMPSLTLACLTKQGQVDLNDAVQALTDLGLIYTAKYPNTS
DLDRLTQSHPILNMIDTKKSSLNISGYNFSLGAAVKAGAC
MLDGGNMLETIKVSPQTMDGILKSILKVKKALGMFISDTP
GERNPYENILYKICLSGDGWPYIASRTSITGRAWENTVVD
LGLTYSQLMTLKDAMLQLDPNAKTWMDIEGRPEDPVEIAL
YQPSSGCYIHFFREPTDLKQFKQDAKYSHGIDVTDLFATQ
PGLTSAVIDALPRNMVITCQGSDDIRKLLESQGRKDIKLI
DIALSKTDSRKYENAVWDQYKDLCHMHTGVVVEKKKEEIT
PHCALMDCIMFDAAVSGGLNTSVLRAVLPRDMVFR
C:  KSFLWTQSLRRELSGYCSNIKLQVVKDAQALLHGLDFSEV
SNVQRLMRKERRDDNDLKRLRDLNQAVNNLVELKSTQQKS
ILRVGTLTSDDLLILAADLEKLKSKVIRTERPLSAGVYMG
NLSSQQLDQRRALLNMIGMDGVVRVWDVKNAELLNNQFGT
MPSLTLACLTKQGQVDLNDAVQALTDLGLIYTAKYPNTSD
LDRLTQSHPILNMIDTSSLNISGYNFSLGAAVKAGACMLD
GNMLETIKVSPQTMDGILKSILKVKKALGMFISDTPGERN
PYENILYKICLSGDGWPYIASRTSITGRAWENTVVDGLTY
SQLMTLKDAMLQLDPNAKTWMDIEGRPEDPVEIALYQPSS
GCYIHFFREPTDLKQFKQDAKYSHGIDVTDLFATQPGLTS
AVIDALPRNMVITCQGSDDIRKLLESQGRKDIKLIDIALS
KTDSRKYENAVWDQYKDLCHMHTGVVVEKKEEITPHCALM
DCIMFDAAVSGGLVLRAVLPRDMVFR
Description


Functional site
1) chain A
residue 399
type
sequence E
description BINDING SITE FOR RESIDUE ZN A 570
source : AC1
2) chain A
residue 412
type
sequence H
description BINDING SITE FOR RESIDUE ZN A 570
source : AC1
3) chain A
residue 506
type
sequence C
description BINDING SITE FOR RESIDUE ZN A 570
source : AC1
4) chain A
residue 509
type
sequence H
description BINDING SITE FOR RESIDUE ZN A 570
source : AC1
5) chain A
residue 529
type
sequence C
description BINDING SITE FOR RESIDUE ZN A 570
source : AC1
6) chain B
residue 399
type
sequence E
description BINDING SITE FOR RESIDUE ZN B 570
source : AC2
7) chain B
residue 412
type
sequence H
description BINDING SITE FOR RESIDUE ZN B 570
source : AC2
8) chain B
residue 506
type
sequence C
description BINDING SITE FOR RESIDUE ZN B 570
source : AC2
9) chain B
residue 509
type
sequence H
description BINDING SITE FOR RESIDUE ZN B 570
source : AC2
10) chain B
residue 529
type
sequence C
description BINDING SITE FOR RESIDUE ZN B 570
source : AC2
11) chain C
residue 399
type
sequence E
description BINDING SITE FOR RESIDUE ZN C 570
source : AC3
12) chain C
residue 506
type
sequence C
description BINDING SITE FOR RESIDUE ZN C 570
source : AC3
13) chain C
residue 509
type
sequence H
description BINDING SITE FOR RESIDUE ZN C 570
source : AC3
14) chain C
residue 529
type
sequence C
description BINDING SITE FOR RESIDUE ZN C 570
source : AC3
15) chain A
residue 389
type BINDING
sequence D
description BINDING => ECO:0000255|HAMAP-Rule:MF_04085, ECO:0000269|PubMed:21085117, ECO:0000269|PubMed:21262835
source Swiss-Prot : SWS_FT_FI1
16) chain A
residue 391
type BINDING
sequence E
description BINDING => ECO:0000255|HAMAP-Rule:MF_04085, ECO:0000269|PubMed:21085117, ECO:0000269|PubMed:21262835
source Swiss-Prot : SWS_FT_FI1
17) chain A
residue 533
type BINDING
sequence D
description BINDING => ECO:0000255|HAMAP-Rule:MF_04085, ECO:0000269|PubMed:21085117, ECO:0000269|PubMed:21262835
source Swiss-Prot : SWS_FT_FI1
18) chain B
residue 389
type BINDING
sequence D
description BINDING => ECO:0000255|HAMAP-Rule:MF_04085, ECO:0000269|PubMed:21085117, ECO:0000269|PubMed:21262835
source Swiss-Prot : SWS_FT_FI1
19) chain B
residue 391
type BINDING
sequence E
description BINDING => ECO:0000255|HAMAP-Rule:MF_04085, ECO:0000269|PubMed:21085117, ECO:0000269|PubMed:21262835
source Swiss-Prot : SWS_FT_FI1
20) chain B
residue 533
type BINDING
sequence D
description BINDING => ECO:0000255|HAMAP-Rule:MF_04085, ECO:0000269|PubMed:21085117, ECO:0000269|PubMed:21262835
source Swiss-Prot : SWS_FT_FI1
21) chain C
residue 389
type BINDING
sequence D
description BINDING => ECO:0000255|HAMAP-Rule:MF_04085, ECO:0000269|PubMed:21085117, ECO:0000269|PubMed:21262835
source Swiss-Prot : SWS_FT_FI1
22) chain C
residue 391
type BINDING
sequence E
description BINDING => ECO:0000255|HAMAP-Rule:MF_04085, ECO:0000269|PubMed:21085117, ECO:0000269|PubMed:21262835
source Swiss-Prot : SWS_FT_FI1
23) chain C
residue 533
type BINDING
sequence D
description BINDING => ECO:0000255|HAMAP-Rule:MF_04085, ECO:0000269|PubMed:21085117, ECO:0000269|PubMed:21262835
source Swiss-Prot : SWS_FT_FI1
24) chain A
residue 399
type BINDING
sequence E
description BINDING => ECO:0000255|HAMAP-Rule:MF_04085, ECO:0000269|PubMed:21085117, ECO:0000269|PubMed:21262835, ECO:0000269|PubMed:22937163, ECO:0000269|PubMed:23615902
source Swiss-Prot : SWS_FT_FI2
25) chain C
residue 506
type BINDING
sequence C
description BINDING => ECO:0000255|HAMAP-Rule:MF_04085, ECO:0000269|PubMed:21085117, ECO:0000269|PubMed:21262835, ECO:0000269|PubMed:22937163, ECO:0000269|PubMed:23615902
source Swiss-Prot : SWS_FT_FI2
26) chain C
residue 509
type BINDING
sequence H
description BINDING => ECO:0000255|HAMAP-Rule:MF_04085, ECO:0000269|PubMed:21085117, ECO:0000269|PubMed:21262835, ECO:0000269|PubMed:22937163, ECO:0000269|PubMed:23615902
source Swiss-Prot : SWS_FT_FI2
27) chain C
residue 529
type BINDING
sequence C
description BINDING => ECO:0000255|HAMAP-Rule:MF_04085, ECO:0000269|PubMed:21085117, ECO:0000269|PubMed:21262835, ECO:0000269|PubMed:22937163, ECO:0000269|PubMed:23615902
source Swiss-Prot : SWS_FT_FI2
28) chain A
residue 506
type BINDING
sequence C
description BINDING => ECO:0000255|HAMAP-Rule:MF_04085, ECO:0000269|PubMed:21085117, ECO:0000269|PubMed:21262835, ECO:0000269|PubMed:22937163, ECO:0000269|PubMed:23615902
source Swiss-Prot : SWS_FT_FI2
29) chain A
residue 509
type BINDING
sequence H
description BINDING => ECO:0000255|HAMAP-Rule:MF_04085, ECO:0000269|PubMed:21085117, ECO:0000269|PubMed:21262835, ECO:0000269|PubMed:22937163, ECO:0000269|PubMed:23615902
source Swiss-Prot : SWS_FT_FI2
30) chain A
residue 529
type BINDING
sequence C
description BINDING => ECO:0000255|HAMAP-Rule:MF_04085, ECO:0000269|PubMed:21085117, ECO:0000269|PubMed:21262835, ECO:0000269|PubMed:22937163, ECO:0000269|PubMed:23615902
source Swiss-Prot : SWS_FT_FI2
31) chain B
residue 399
type BINDING
sequence E
description BINDING => ECO:0000255|HAMAP-Rule:MF_04085, ECO:0000269|PubMed:21085117, ECO:0000269|PubMed:21262835, ECO:0000269|PubMed:22937163, ECO:0000269|PubMed:23615902
source Swiss-Prot : SWS_FT_FI2
32) chain B
residue 506
type BINDING
sequence C
description BINDING => ECO:0000255|HAMAP-Rule:MF_04085, ECO:0000269|PubMed:21085117, ECO:0000269|PubMed:21262835, ECO:0000269|PubMed:22937163, ECO:0000269|PubMed:23615902
source Swiss-Prot : SWS_FT_FI2
33) chain B
residue 509
type BINDING
sequence H
description BINDING => ECO:0000255|HAMAP-Rule:MF_04085, ECO:0000269|PubMed:21085117, ECO:0000269|PubMed:21262835, ECO:0000269|PubMed:22937163, ECO:0000269|PubMed:23615902
source Swiss-Prot : SWS_FT_FI2
34) chain B
residue 529
type BINDING
sequence C
description BINDING => ECO:0000255|HAMAP-Rule:MF_04085, ECO:0000269|PubMed:21085117, ECO:0000269|PubMed:21262835, ECO:0000269|PubMed:22937163, ECO:0000269|PubMed:23615902
source Swiss-Prot : SWS_FT_FI2
35) chain C
residue 399
type BINDING
sequence E
description BINDING => ECO:0000255|HAMAP-Rule:MF_04085, ECO:0000269|PubMed:21085117, ECO:0000269|PubMed:21262835, ECO:0000269|PubMed:22937163, ECO:0000269|PubMed:23615902
source Swiss-Prot : SWS_FT_FI2
36) chain A
residue 466
type SITE
sequence D
description Important for exonuclease activity => ECO:0000255|HAMAP-Rule:MF_04085, ECO:0000269|PubMed:21085117
source Swiss-Prot : SWS_FT_FI3
37) chain B
residue 466
type SITE
sequence D
description Important for exonuclease activity => ECO:0000255|HAMAP-Rule:MF_04085, ECO:0000269|PubMed:21085117
source Swiss-Prot : SWS_FT_FI3
38) chain C
residue 466
type SITE
sequence D
description Important for exonuclease activity => ECO:0000255|HAMAP-Rule:MF_04085, ECO:0000269|PubMed:21085117
source Swiss-Prot : SWS_FT_FI3

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