eF-site ID 3mtn-C
PDB Code 3mtn
Chain C

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Title Usp21 in complex with a ubiquitin-based, USP21-specific inhibitor
Classification HYDROLASE
Compound Ubiquitin carboxyl-terminal hydrolase 21
Source Homo sapiens (Human) (P62988)
Sequence C:  GHVGLRNLGNTCFLNAVLQCLSSTRPLRDFCLRRDFRQEV
PGGGRAQELTEAFADVIGALWHPDSCEAVNPTRFRAVFQK
YVPSFSGYSQQDAQEFLKLLMERLHLEINRRSDDDRANLM
WKRYLEREDSKIVDLFVGQLKSCLKCQACGYRSTTFEVFC
DLSLPIPKKGFGKVSLRDCFNLFTKEEELESENAPVCDRC
RQKTRSTKKLTVQRFPRILVLHLNRFSASRGSIKKSSVGV
DFPLQRLSLGDFASSPVYQLYALCNHSGSVHYGHYTALCR
CQTGWHVYNDSRVSPVSENQVASSEGYVLFYQLM
Description


Functional site
1) chain C
residue 384
type
sequence C
description BINDING SITE FOR RESIDUE ZN C 700
source : AC2
2) chain C
residue 387
type
sequence C
description BINDING SITE FOR RESIDUE ZN C 700
source : AC2
3) chain C
residue 437
type
sequence C
description BINDING SITE FOR RESIDUE ZN C 700
source : AC2
4) chain C
residue 440
type
sequence C
description BINDING SITE FOR RESIDUE ZN C 700
source : AC2
5) chain C
residue 401
type
sequence S
description BINDING SITE FOR RESIDUE CL C 1
source : AC4
6) chain C
residue 311
type
sequence E
description BINDING SITE FOR RESIDUE GOL C 3
source : AC7
7) chain C
residue 314
type
sequence H
description BINDING SITE FOR RESIDUE GOL C 3
source : AC7
8) chain C
residue 370
type
sequence I
description BINDING SITE FOR RESIDUE GOL C 3
source : AC7
9) chain C
residue 371
type
sequence V
description BINDING SITE FOR RESIDUE GOL C 3
source : AC7
10) chain C
residue 384
type MOD_RES
sequence C
description Phosphoserine; by PINK1 => ECO:0000269|PubMed:24660806, ECO:0000269|PubMed:24751536, ECO:0000269|PubMed:24784582, ECO:0000269|PubMed:25527291
source Swiss-Prot : SWS_FT_FI3
11) chain C
residue 387
type MOD_RES
sequence C
description Phosphoserine; by PINK1 => ECO:0000269|PubMed:24660806, ECO:0000269|PubMed:24751536, ECO:0000269|PubMed:24784582, ECO:0000269|PubMed:25527291
source Swiss-Prot : SWS_FT_FI3
12) chain C
residue 437
type MOD_RES
sequence C
description Phosphoserine; by PINK1 => ECO:0000269|PubMed:24660806, ECO:0000269|PubMed:24751536, ECO:0000269|PubMed:24784582, ECO:0000269|PubMed:25527291
source Swiss-Prot : SWS_FT_FI3
13) chain C
residue 440
type MOD_RES
sequence C
description Phosphoserine; by PINK1 => ECO:0000269|PubMed:24660806, ECO:0000269|PubMed:24751536, ECO:0000269|PubMed:24784582, ECO:0000269|PubMed:25527291
source Swiss-Prot : SWS_FT_FI3

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