eF-site ID 3ms7-A PDB Code 3ms7 Chain A click to enlarge Title Glycogen phosphorylase complexed with 2-chlorobenzaldehyde-4-(2,3,4,6-tetra-O-acetyl-beta-D-glucopyranosyl) thiosemicarbazone Classification TRANSFERASE/TRANSFERASE INHIBITOR Compound Glycogen phosphorylase, muscle form Source ORGANISM_COMMON: European rabbit,Japanese white rabbit,domestic rabbit,rabbits; ORGANISM_SCIENTIFIC: Oryctolagus cuniculus; Sequence A:  QISVRGLAGVENVTELKKNFNRHLHFTLVKDRNVATPRDY YFALAHTVRDHLVGRWIRTQQHYYEKDPKRIYYLSLEFYM GRTLQNTMVNLALENACDEATYQLGLDMEELEEIEEDAGL GNGGLGRLAACFLDSMATLGLAAYGYGIRYEFGIFNQKIC GGWQMEEADDWLRYGNPWEKARPEFTLPVHFYGRVEHTSQ GAKWVDTQVVLAMPYDTPVPGYRNNVVNTMRLWSAKAPND FNLGYIQAVLDRNLAENISRVLYPNDNFFEGKELRLKQEY FVVAATLQDIIRRFKSSNFDAFPDKVAIQLNDTHPSLAIP ELMRVLVDLERLDWDKAWEVTVKTCAYTNHTVLPEALERW PVHLLETLLPRHLQIIYEINQRFLNRVAAAFPGDVDRLRR MSLVEEGAVKRINMAHLCIAGSHAVNGVARIHSEILKKTI FKDFYELEPHKFQNKTNGITPRRWLVLCNPGLAEIIAERI GEEYISDLDQLRKLLSYVDDEAFIRDVAKVKQENKLKFAA YLEREYKVHINPNSLFDVQVKRIHEYKRQLLNCLHVITLY NRIKKEPNKFVVPRTVMIGGKAAPGYHMAKMIIKLITAIG DVVNHDPVVGDRLRVIFLENYRVSLAEKVIPAADLSEQIS TAGTEASGTGNMXFMLNGALTIGTMDGANVEMAEEAGEEN FFIFGMRVEDVDRLDQRGYNAQEYYDRIPELRQIIEQLSS GFFSPKQPDLFKDIVNMLMHHDRFKVFADYEEYVKCQERV SALYKNPREWTRMVIRNIATSGKFSSDRTIAQYAREIWGV EPSRQRLPA Description Functional site 1) chain A residue 746 type MOD_RES sequence S description Phosphoserine => ECO:0000250|UniProtKB:P09812 source Swiss-Prot : SWS_FT_FI10 2) chain A residue 747 type MOD_RES sequence S description Phosphoserine => ECO:0000250|UniProtKB:P09812 source Swiss-Prot : SWS_FT_FI10 3) chain A residue 513 type MOD_RES sequence S description Phosphoserine => ECO:0000250|UniProtKB:P09812 source Swiss-Prot : SWS_FT_FI10 4) chain A residue 680 type MOD_RES sequence X description N6-(pyridoxal phosphate)lysine => ECO:0000269|PubMed:7500360, ECO:0000269|PubMed:8976550, ECO:0007744|PDB:2PRI, ECO:0007744|PDB:2SKC, ECO:0007744|PDB:2SKD, ECO:0007744|PDB:2SKE source Swiss-Prot : SWS_FT_FI11 5) chain A residue 309 type BINDING sequence R description BINDING => ECO:0000250|UniProtKB:P11217 source Swiss-Prot : SWS_FT_FI1 6) chain A residue 42 type BINDING sequence D description BINDING => ECO:0000250|UniProtKB:P11217 source Swiss-Prot : SWS_FT_FI1 7) chain A residue 75 type BINDING sequence Y description BINDING => ECO:0000269|PubMed:3616621 source Swiss-Prot : SWS_FT_FI2 8) chain A residue 142 type SITE sequence C description Involved in the association of subunits => ECO:0000303|PubMed:728424 source Swiss-Prot : SWS_FT_FI3 9) chain A residue 108 type SITE sequence C description Involved in the association of subunits => ECO:0000303|PubMed:728424 source Swiss-Prot : SWS_FT_FI3 10) chain A residue 155 type SITE sequence Y description Can be labeled by an AMP analog; may be involved in allosteric regulation => ECO:0000303|PubMed:728424 source Swiss-Prot : SWS_FT_FI4 11) chain A residue 14 type MOD_RES sequence S description Phosphoserine; by PHK; in form phosphorylase A => ECO:0000250|UniProtKB:P11217 source Swiss-Prot : SWS_FT_FI6 12) chain A residue 226 type MOD_RES sequence Y description Phosphotyrosine => ECO:0000250|UniProtKB:P09812 source Swiss-Prot : SWS_FT_FI7 13) chain A residue 203 type MOD_RES sequence Y description Phosphotyrosine => ECO:0000250|UniProtKB:P09812 source Swiss-Prot : SWS_FT_FI7 14) chain A residue 429 type MOD_RES sequence S description Phosphoserine => ECO:0000250|UniProtKB:Q9WUB3 source Swiss-Prot : SWS_FT_FI8 15) chain A residue 472 type MOD_RES sequence Y description Phosphotyrosine => ECO:0000250|UniProtKB:Q9WUB3 source Swiss-Prot : SWS_FT_FI9 16) chain A residue 672-684 type prosite sequence EASGTGNMXFMLN description PHOSPHORYLASE Phosphorylase pyridoxal-phosphate attachment site. EASGtGnMKfmLN source prosite : PS00102 17) chain A residue 377 type catalytic sequence H description 205 source MCSA : MCSA1 18) chain A residue 568 type catalytic sequence K description 205 source MCSA : MCSA1 19) chain A residue 569 type catalytic sequence R description 205 source MCSA : MCSA1 20) chain A residue 574 type catalytic sequence K description 205 source MCSA : MCSA1 21) chain A residue 676 type catalytic sequence T description 205 source MCSA : MCSA1 22) chain A residue 680 type catalytic sequence X description 205 source MCSA : MCSA1

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