eF-site ID 3mku-AB PDB Code 3mku Chain A, B click to enlarge Title Structure of a Cation-bound Multidrug and Toxin Compound Extrusion (MATE) transporter Classification TRANSPORT PROTEIN Compound Multi antimicrobial extrusion protein (Na(+)/drug antiporter) MATE-like MDR efflux pump Source Vibrio cholerae serotype O1 (strain MJ-1236) (C3NQD8_VIBCJ) Sequence A:  ENSVHRYKKEASNLIKLATPVLIASVAQTGMGFVDTIMAG GVSAIDMAAVSIAASIWLPSILFGVGLLMALVPVVAQLNG AGRQHKIPFEVHQGLILALLVSVPIIAVLFQTQFIIRFMD VEEAMATKTVGYMHAVIFAVPAYLLFQALRSFTDGMSLTK PAMVIGFIGLLLNIPLNWIFVYGKFGAPELGGVGCGVATA IVYWIMLLLLLFYIVTSKRLAHVKVFETFHKPQPKELIRL FRLGFPVAAALFFEVTLFAVVALLVAPLGSTVVAAHQVAL NFSSLVFMFPMSIGAAVSIRVGHKLGEQDTKGAAIAANVG LMTGLATACITALLTVLFREQIALLYTENQVVVALAMQLL LFAAIYQCMDAVQVVAAGSLRGYKDMTAIFHRTFISYWVL GLPTGYILGMTNWLTEQPLGAKGFWLGFIIGLSAAALMLG QRLYWLQKQSDDVQLHLAAK B:  ENSVHRYKKEASNLIKLATPVLIASVAQTGMGFVDTIMAG GVSAIDMAAVSIAASIWLPSILFGVGLLMALVPVVAQLNG AGRQHKIPFEVHQGLILALLVSVPIIAVLFQTQFIIRFMD VEEAMATKTVGYMHAVIFAVPAYLLFQALRSFTDGMSLTK PAMVIGFIGLLLNIPLNWIFVYGKFGAPELGGVGCGVATA IVYWIMLLLLLFYIVTSKRLAHVKVFETFHKPQPKELIRL FRLGFPVAAALFFEVTLFAVVALLVAPLGSTVVAAHQVAL NFSSLVFMFPMSIGAAVSIRVGHKLGEQDTKGAAIAANVG LMTGLATACITALLTVLFREQIALLYTENQVVVALAMQLL LFAAIYQCMDAVQVVAAGSLRGYKDMTAIFHRTFISYWVL GLPTGYILGMTNWLTEQPLGAKGFWLGFIIGLSAAALMLG QRLYWLQKQSDDVQLHLAAK Description Functional site 1) chain A residue 259 type sequence F description BINDING SITE FOR RESIDUE RB A 5001 source : AC1 2) chain A residue 367 type sequence Y description BINDING SITE FOR RESIDUE RB A 5001 source : AC1 3) chain B residue 259 type sequence F description BINDING SITE FOR RESIDUE RB B 5002 source : AC2 4) chain B residue 367 type sequence Y description BINDING SITE FOR RESIDUE RB B 5002 source : AC2

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