eF-site ID 3mks-ABCD PDB Code 3mks Chain A, B, C, D click to enlarge Title Crystal Structure of yeast Cdc4/Skp1 in complex with an allosteric inhibitor SCF-I2 Classification LIGASE/CELL CYCLE Compound Suppressor of kinetochore protein 1 Source (CDC4_YEAST) Sequence A:  SNVVLVSGEGERFTVDKKIAERSLLLKNYEIVMPVPNVRS SVLQKVIEWAEHHRDSNFPDKSAPVDSWDREFLKVDQEML YEIILAANYLNIKPLLDAGCKVVAEMIRGRSPEEIRRTFN IVNDFTPEEEAAIR B:  LKRDLITSLPFEISLKIFNYLQFEDIINSLGVSQNWNKII RKSTSLWKKLLISENFVSPKGFNSLNLKLSQKYPKLSQQD RLRLSFLENIFILKNWYNPKFVPQRTTLRGHMTSVITCLQ FEDNYVITGADDKMIRVYDSINKKFLLQLSGHDGGVWALK YAHGGILVSGSTDRTVRVWDIKKGCCTHVFEGHNSTVRCL DIVEYKNIKYIVTGSRDNTLHVWKLPKDYPLVFHTPEENP YFVGVLRGHMASVRTVSGHGNIVVSGSYDNTLIVWDVAQM KCLYILSGHTDRIYSTIYDHERKRCISASMDTTIRIWDLE NGELMYTLQGHTALVGLLRLSDKFLVSAAADGSIRGWDAN DYSRKFSYHHTNLSAITTFYVSDNILVSGSENQFNIYNLR SGKLVHANILKDADQIWSVNFKGKTLVAAVEKDGQSFLEI LDFS C:  SNVVLVSGEGERFTVDKKIAERSLLLKNYLNIVMPVPNVR SSVLQKVIEWAEHHRDSNFPPVDSWDREFLKVDQEMLYEI ILAANYLNIKPLLDAGCKVVAEMIRGRSPEEIRRTFNIVN DFTPEEEAAIRR D:  NLKRDLITSLPFEISLKIFNYLQFEDIINSLGVSQNWNKI IRKSTSLWKKLLISENFVSPKGFNSLNLKLSQKYPKLSQQ DRLRLSFLENIFILKNWYNPKFVPQRTTLRGHMTSVITCL QFEDNYVITGADDKMIRVYDSINKKFLLQLSGHDGGVWAL KYAHGGILVSGSTDRTVRVWDIKKGCCTHVFEGHNSTVRC LDIVEYKNIKYIVTGSRDNTLHVWKLPKEYPLVFHTPEEN PYFVGVLRGHMASVRTVSGHGNIVVSGSYDNTLIVWDVAQ MKCLYILSGHTDRIYSTIYDHERKRCISASMDTTIRIWDL ENGELMYTLQGHTALVGLLRLSDKFLVSAAADGSIRGWDA NDYSRKFSYHHTNLSAITTFYVSDNILVSGSENQFNIYNL RSGKLVHANILKDADQIWSVNFKGKTLVAAVEKDGQSFLE ILDFS Description Functional site 1) chain B residue 280 type sequence F description BINDING SITE FOR RESIDUE SO4 B 1 source : AC1 2) chain B residue 311 type sequence K description BINDING SITE FOR RESIDUE SO4 B 1 source : AC1 3) chain B residue 312 type sequence S description BINDING SITE FOR RESIDUE SO4 B 1 source : AC1 4) chain B residue 314 type sequence S description BINDING SITE FOR RESIDUE SO4 B 1 source : AC1 5) chain B residue 280 type sequence F description BINDING SITE FOR RESIDUE SO4 B 3 source : AC2 6) chain B residue 389 type sequence Q description BINDING SITE FOR RESIDUE SO4 B 4 source : AC3 7) chain B residue 639 type sequence R description BINDING SITE FOR RESIDUE SO4 B 4 source : AC3 8) chain B residue 720 type sequence N description BINDING SITE FOR RESIDUE SO4 B 4 source : AC3 9) chain B residue 706 type sequence H description BINDING SITE FOR RESIDUE SO4 B 6 source : AC4 10) chain B residue 707 type sequence A description BINDING SITE FOR RESIDUE SO4 B 6 source : AC4 11) chain B residue 708 type sequence N description BINDING SITE FOR RESIDUE SO4 B 6 source : AC4 12) chain B residue 709 type sequence I description BINDING SITE FOR RESIDUE SO4 B 6 source : AC4 13) chain B residue 365 type sequence W description BINDING SITE FOR RESIDUE SO4 B 7 source : AC5 14) chain B residue 682 type sequence S description BINDING SITE FOR RESIDUE SO4 B 7 source : AC5 15) chain B residue 685 type sequence I description BINDING SITE FOR RESIDUE SO4 B 7 source : AC5 16) chain B residue 721 type sequence F description BINDING SITE FOR RESIDUE SO4 B 7 source : AC5 17) chain B residue 723 type sequence G description BINDING SITE FOR RESIDUE SO4 B 7 source : AC5 18) chain D residue 629 type sequence Q description BINDING SITE FOR RESIDUE C1C D 1 source : AC6 19) chain D residue 630 type sequence G description BINDING SITE FOR RESIDUE C1C D 1 source : AC6 20) chain D residue 632 type sequence T description BINDING SITE FOR RESIDUE C1C D 1 source : AC6 21) chain D residue 655 type sequence R description BINDING SITE FOR RESIDUE C1C D 1 source : AC6 22) chain D residue 656 type sequence G description BINDING SITE FOR RESIDUE C1C D 1 source : AC6 23) chain D residue 657 type sequence W description BINDING SITE FOR RESIDUE C1C D 1 source : AC6 24) chain D residue 664 type sequence R description BINDING SITE FOR RESIDUE C1C D 1 source : AC6 25) chain D residue 666 type sequence F description BINDING SITE FOR RESIDUE C1C D 1 source : AC6 26) chain D residue 667 type sequence S description BINDING SITE FOR RESIDUE C1C D 1 source : AC6 27) chain D residue 665 type sequence K description BINDING SITE FOR RESIDUE SO4 D 2 source : AC7 28) chain D residue 699 type sequence L description BINDING SITE FOR RESIDUE SO4 D 2 source : AC7 29) chain D residue 700 type sequence R description BINDING SITE FOR RESIDUE SO4 D 2 source : AC7 30) chain D residue 702 type sequence G description BINDING SITE FOR RESIDUE SO4 D 2 source : AC7 31) chain D residue 471 type sequence I description BINDING SITE FOR RESIDUE SO4 D 5 source : AC8 32) chain D residue 472 type sequence V description BINDING SITE FOR RESIDUE SO4 D 5 source : AC8 33) chain D residue 473 type sequence E description BINDING SITE FOR RESIDUE SO4 D 5 source : AC8 34) chain D residue 539 type sequence H description BINDING SITE FOR RESIDUE SO4 D 5 source : AC8 35) chain D residue 540 type sequence G description BINDING SITE FOR RESIDUE SO4 D 5 source : AC8 36) chain D residue 467 type sequence R description BINDING SITE FOR RESIDUE SO4 D 8 source : AC9 37) chain D residue 485 type sequence R description BINDING SITE FOR RESIDUE SO4 D 8 source : AC9 38) chain D residue 548 type sequence Y description BINDING SITE FOR RESIDUE SO4 D 8 source : AC9 39) chain D residue 340 type sequence Q description BINDING SITE FOR RESIDUE SO4 D 9 source : BC1 40) chain D residue 432 type sequence H description BINDING SITE FOR RESIDUE SO4 D 9 source : BC1 41) chain D residue 279 type sequence P description BINDING SITE FOR RESIDUE SO4 D 10 source : BC2 42) chain D residue 280 type sequence F description BINDING SITE FOR RESIDUE SO4 D 10 source : BC2 43) chain D residue 284 type sequence L description BINDING SITE FOR RESIDUE SO4 D 11 source : BC3 44) chain D residue 311 type sequence K description BINDING SITE FOR RESIDUE SO4 D 11 source : BC3 45) chain D residue 312 type sequence S description BINDING SITE FOR RESIDUE SO4 D 11 source : BC3 46) chain D residue 313 type sequence T description BINDING SITE FOR RESIDUE SO4 D 11 source : BC3 47) chain D residue 314 type sequence S description BINDING SITE FOR RESIDUE SO4 D 11 source : BC3 48) chain D residue 389 type sequence Q description BINDING SITE FOR RESIDUE GOL D 745 source : BC4 49) chain D residue 639 type sequence R description BINDING SITE FOR RESIDUE GOL D 745 source : BC4 50) chain D residue 680 type sequence Y description BINDING SITE FOR RESIDUE GOL D 745 source : BC4 51) chain D residue 720 type sequence N description BINDING SITE FOR RESIDUE GOL D 745 source : BC4 52) chain B residue 436-450 type prosite sequence LVSGSTDRTVRVWDI description WD_REPEATS_1 Trp-Asp (WD) repeats signature. LVSGstDrTVRVWDI source prosite : PS00678 53) chain B residue 543-557 type prosite sequence VVSGSYDNTLIVWDV description WD_REPEATS_1 Trp-Asp (WD) repeats signature. LVSGstDrTVRVWDI source prosite : PS00678 54) chain B residue 585-599 type prosite sequence CISASMDTTIRIWDL description WD_REPEATS_1 Trp-Asp (WD) repeats signature. LVSGstDrTVRVWDI source prosite : PS00678 55) chain B residue 645-659 type prosite sequence LVSAAADGSIRGWDA description WD_REPEATS_1 Trp-Asp (WD) repeats signature. LVSGstDrTVRVWDI source prosite : PS00678

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