eF-site ID 3mji-ABCD PDB Code 3mji Chain A, B, C, D click to enlarge Title Activation of catalytic cysteine without a base in a Mutant Penicillin Acylase Precursor Classification HYDROLASE Compound Penicillin acylase Source Lysinibacillus sphaericus (Bacillus sphaericus) (PAC_BACSH) Sequence A:  MLGSSSLSIRTTDDKSLFARTMDFTMEPDSKVIIVPRNYG IRLLEKENVVINNSYAFVGMGSTDITSPVLYDGVNEKGLM GAMLYYATFATYADEPKKGTRGINPVYVISQVLGNCVTVD DVIEKLTSYTLLNEANIILGFAPPLHYTFTDASGESIVIE PDKTGITIHRKTIGVMTNSPGYEWHQTNLRAYIGVTPNPP QDIMMGDLDLTPFGQGAGGLGLPGDFTPSARFLRVAYWKK YTEKAKNETEGVTNLFHILSSVNIPKGVVLTNEGKTDYTI YTSAMCAQSKNYYFKLYDNSRISAVSLMAENLNSQDLITF EWDRKQDIKQLNQV B:  MLGSSSLSIRTTDDKSLFARTMDFTMEPDSKVIIVPRNYG IRLLEKENVVINNSYAFVGMGSTDITSPVLYDGVNEKGLM GAMLYYATFATYADEPKKGTRGINPVYVISQVLGNCVTVD DVIEKLTSYTLLNEANIILGFAPPLHYTFTDASGESIVIE PDKTGITIHRKTIGVMTNSPGYEWHQTNLRAYIGVTPNPP QDIMMGDLDLTPFGQGAGGLGLPGDFTPSARFLRVAYWKK YTEKAKNETEGVTNLFHILSSVNIPKGVVLTNEGKTDYTI YTSAMCAQSKNYYFKLYDNSRISAVSLMAENLNSQDLITF EWDRKQDIKQLNQV C:  MLGSSSLSIRTTDDKSLFARTMDFTMEPDSKVIIVPRNYG IRLLEKENVVINNSYAFVGMGSTDITSPVLYDGVNEKGLM GAMLYYATFATYADEPKKGTRGINPVYVISQVLGNCVTVD DVIEKLTSYTLLNEANIILGFAPPLHYTFTDASGESIVIE PDKTGITIHRKTIGVMTNSPGYEWHQTNLRAYIGVTPNPP QDIMMGDLDLTPFGQGAGGLGLPGDFTPSARFLRVAYWKK YTEKAKNETEGVTNLFHILSSVNIPKGVVLTNEGKTDYTI YTSAMCAQSKNYYFKLYDNSRISAVSLMAENLNSQDLITF EWDRKQDIKQLNQ D:  MLGSSSLSIRTTDDKSLFARTMDFTMEPDSKVIIVPRNYG IRLLEKENVVINNSYAFVGMGSTDITSPVLYDGVNEKGLM GAMLYYATFATYADEPKKGTRGINPVYVISQVLGNCVTVD DVIEKLTSYTLLNEANIILGFAPPLHYTFTDASGESIVIE PDKTGITIHRKTIGVMTNSPGYEWHQTNLRAYIGVTPNPP QDIMMGDLDLTPFGQGAGGLGLPGDFTPSARFLRVAYWKK YTEKAKNETEGVTNLFHILSSVNIPKGVVLTNEGKTDYTI YTSAMCAQSKNYYFKLYDNSRISAVSLMAENLNSQDLITF EWDRKQDIKQLNQ Description Functional site 1) chain A residue 4 type catalytic sequence S description 241 source MCSA : MCSA1 2) chain A residue 85 type catalytic sequence Y description 241 source MCSA : MCSA1 3) chain A residue 178 type catalytic sequence N description 241 source MCSA : MCSA1 4) chain A residue 231 type catalytic sequence R description 241 source MCSA : MCSA1 5) chain B residue 4 type catalytic sequence S description 241 source MCSA : MCSA2 6) chain B residue 85 type catalytic sequence Y description 241 source MCSA : MCSA2 7) chain B residue 178 type catalytic sequence N description 241 source MCSA : MCSA2 8) chain B residue 231 type catalytic sequence R description 241 source MCSA : MCSA2 9) chain C residue 4 type catalytic sequence S description 241 source MCSA : MCSA3 10) chain C residue 85 type catalytic sequence Y description 241 source MCSA : MCSA3 11) chain C residue 178 type catalytic sequence N description 241 source MCSA : MCSA3 12) chain C residue 231 type catalytic sequence R description 241 source MCSA : MCSA3 13) chain D residue 4 type catalytic sequence S description 241 source MCSA : MCSA4 14) chain D residue 85 type catalytic sequence Y description 241 source MCSA : MCSA4 15) chain D residue 178 type catalytic sequence N description 241 source MCSA : MCSA4 16) chain D residue 231 type catalytic sequence R description 241 source MCSA : MCSA4 17) chain B residue 4 type ACT_SITE sequence S description source Swiss-Prot : SWS_FT_FI1 18) chain C residue 4 type ACT_SITE sequence S description source Swiss-Prot : SWS_FT_FI1 19) chain D residue 4 type ACT_SITE sequence S description source Swiss-Prot : SWS_FT_FI1 20) chain A residue 4 type ACT_SITE sequence S description source Swiss-Prot : SWS_FT_FI1

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