eF-site ID 3mis-ABCD PDB Code 3mis Chain A, B, C, D click to enlarge Title I-MsoI re-designed for altered DNA cleavage specificity (-8G) Classification DE NOVO PROTEIN/DNA Compound Mso-8G Source (3MIS) Sequence A:  TLQPTEAAYIAGFLDGDGSIYAKLEPRPDYKDIKYQVRLA ISFIQRKDKFPYLQDIYDQLGKRGNLRKDRGDGIADYTIY GSTHLSIILPDLVPYLRIKKKQANRILHIINLYPQAQKNP SKFLDLVKIVDDVQNLNKRADELKSTNYDRLLEEFLKAGK I B:  TLQPTEAAYIAGFLDGDGSIYAKLEPRPDYKDIKYQVRLA ISFIQRKDKFPYLQDIYDQLGKRGNLRKDRGDGIADYTIY GSTHLSIILPDLVPYLRIKKKQANRILHIINLYPQAQKNP SKFLDLVKIVDDVQNLNKRADELKSTNYDRLLEEFLKAGK I C:  GCAGGACGTCGTGAGACAGCTCCG D:  CGGAGCTGTCTCACGACGTCCTGC Description Functional site 1) chain A residue 22 type sequence D description BINDING SITE FOR RESIDUE CA A 2 source : AC1 2) chain B residue 21 type sequence G description BINDING SITE FOR RESIDUE CA A 2 source : AC1 3) chain C residue 3 type sequence G description BINDING SITE FOR RESIDUE CA A 2 source : AC1 4) chain D residue 2 type sequence C description BINDING SITE FOR RESIDUE CA A 2 source : AC1 5) chain A residue 21 type sequence G description BINDING SITE FOR RESIDUE CA B 3 source : AC2 6) chain B residue 22 type sequence D description BINDING SITE FOR RESIDUE CA B 3 source : AC2 7) chain C residue 2 type sequence A description BINDING SITE FOR RESIDUE CA B 3 source : AC2 8) chain D residue 3 type sequence G description BINDING SITE FOR RESIDUE CA B 3 source : AC2 9) chain A residue 22 type sequence D description BINDING SITE FOR RESIDUE CA C 13 source : AC3 10) chain B residue 22 type sequence D description BINDING SITE FOR RESIDUE CA C 13 source : AC3 11) chain C residue 2 type sequence A description BINDING SITE FOR RESIDUE CA C 13 source : AC3 12) chain C residue 3 type sequence G description BINDING SITE FOR RESIDUE CA C 13 source : AC3 13) chain D residue 2 type sequence C description BINDING SITE FOR RESIDUE CA C 13 source : AC3 14) chain D residue 3 type sequence G description BINDING SITE FOR RESIDUE CA C 13 source : AC3

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