eF-site ID 3m3j-ABCDEF PDB Code 3m3j Chain A, B, C, D, E, F click to enlarge Title A new crystal form of Lys48-linked diubiquitin Classification SIGNALING PROTEIN Compound Ubiquitin Source ORGANISM_COMMON: bovine,cow,domestic cattle,domestic cow; ORGANISM_SCIENTIFIC: Bos taurus; Sequence A:  MQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQ QRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGG B:  MQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQ QRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRG C:  MQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQ QRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGG D:  MQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQ QRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRL E:  MQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQ QRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGG F:  MQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQ QRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRL Description (1)  Lys48-linked diubiquitin Functional site 1) chain A residue 6 type sequence K description BINDING SITE FOR RESIDUE EDO A 77 source : AC1 2) chain A residue 68 type sequence H description BINDING SITE FOR RESIDUE EDO A 77 source : AC1 3) chain C residue 6 type sequence K description BINDING SITE FOR RESIDUE EDO A 77 source : AC1 4) chain C residue 68 type sequence H description BINDING SITE FOR RESIDUE EDO A 77 source : AC1 5) chain A residue 42 type sequence R description BINDING SITE FOR RESIDUE SO4 B 77 source : AC2 6) chain A residue 49 type sequence Q description BINDING SITE FOR RESIDUE SO4 B 77 source : AC2 7) chain A residue 72 type sequence R description BINDING SITE FOR RESIDUE SO4 B 77 source : AC2 8) chain B residue 42 type sequence R description BINDING SITE FOR RESIDUE SO4 B 77 source : AC2 9) chain B residue 72 type sequence R description BINDING SITE FOR RESIDUE SO4 B 77 source : AC2 10) chain C residue 42 type sequence R description BINDING SITE FOR RESIDUE SO4 C 77 source : AC3 11) chain C residue 49 type sequence Q description BINDING SITE FOR RESIDUE SO4 C 77 source : AC3 12) chain D residue 42 type sequence R description BINDING SITE FOR RESIDUE SO4 C 77 source : AC3 13) chain D residue 49 type sequence Q description BINDING SITE FOR RESIDUE SO4 C 77 source : AC3 14) chain E residue 42 type sequence R description BINDING SITE FOR RESIDUE SO4 E 77 source : AC4 15) chain E residue 49 type sequence Q description BINDING SITE FOR RESIDUE SO4 E 77 source : AC4 16) chain F residue 42 type sequence R description BINDING SITE FOR RESIDUE SO4 E 77 source : AC4 17) chain F residue 72 type sequence R description BINDING SITE FOR RESIDUE SO4 E 77 source : AC4 18) chain A residue 65 type MOD_RES sequence S description Phosphoserine; by PINK1 => ECO:0000250|UniProtKB:P0CG48 source Swiss-Prot : SWS_FT_FI3 19) chain B residue 65 type MOD_RES sequence S description Phosphoserine; by PINK1 => ECO:0000250|UniProtKB:P0CG48 source Swiss-Prot : SWS_FT_FI3 20) chain C residue 65 type MOD_RES sequence S description Phosphoserine; by PINK1 => ECO:0000250|UniProtKB:P0CG48 source Swiss-Prot : SWS_FT_FI3 21) chain D residue 65 type MOD_RES sequence S description Phosphoserine; by PINK1 => ECO:0000250|UniProtKB:P0CG48 source Swiss-Prot : SWS_FT_FI3 22) chain E residue 65 type MOD_RES sequence S description Phosphoserine; by PINK1 => ECO:0000250|UniProtKB:P0CG48 source Swiss-Prot : SWS_FT_FI3 23) chain F residue 65 type MOD_RES sequence S description Phosphoserine; by PINK1 => ECO:0000250|UniProtKB:P0CG48 source Swiss-Prot : SWS_FT_FI3 24) chain A residue 76 type MOD_RES sequence G description ADP-ribosylglycine => ECO:0000250|UniProtKB:P0CG48 source Swiss-Prot : SWS_FT_FI4 25) chain C residue 76 type MOD_RES sequence G description ADP-ribosylglycine => ECO:0000250|UniProtKB:P0CG48 source Swiss-Prot : SWS_FT_FI4 26) chain E residue 76 type MOD_RES sequence G description ADP-ribosylglycine => ECO:0000250|UniProtKB:P0CG48 source Swiss-Prot : SWS_FT_FI4 27) chain A residue 6 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000250|UniProtKB:P0CG48 source Swiss-Prot : SWS_FT_FI5 28) chain B residue 27 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000250|UniProtKB:P0CG48 source Swiss-Prot : SWS_FT_FI5 29) chain B residue 29 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000250|UniProtKB:P0CG48 source Swiss-Prot : SWS_FT_FI5 30) chain B residue 33 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000250|UniProtKB:P0CG48 source Swiss-Prot : SWS_FT_FI5 31) chain B residue 48 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000250|UniProtKB:P0CG48 source Swiss-Prot : SWS_FT_FI5 32) chain B residue 63 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000250|UniProtKB:P0CG48 source Swiss-Prot : SWS_FT_FI5 33) chain C residue 6 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000250|UniProtKB:P0CG48 source Swiss-Prot : SWS_FT_FI5 34) chain C residue 11 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000250|UniProtKB:P0CG48 source Swiss-Prot : SWS_FT_FI5 35) chain C residue 27 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000250|UniProtKB:P0CG48 source Swiss-Prot : SWS_FT_FI5 36) chain C residue 29 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000250|UniProtKB:P0CG48 source Swiss-Prot : SWS_FT_FI5 37) chain C residue 33 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000250|UniProtKB:P0CG48 source Swiss-Prot : SWS_FT_FI5 38) chain A residue 11 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000250|UniProtKB:P0CG48 source Swiss-Prot : SWS_FT_FI5 39) chain C residue 48 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000250|UniProtKB:P0CG48 source Swiss-Prot : SWS_FT_FI5 40) chain C residue 63 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000250|UniProtKB:P0CG48 source Swiss-Prot : SWS_FT_FI5 41) chain D residue 6 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000250|UniProtKB:P0CG48 source Swiss-Prot : SWS_FT_FI5 42) chain D residue 11 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000250|UniProtKB:P0CG48 source Swiss-Prot : SWS_FT_FI5 43) chain D residue 27 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000250|UniProtKB:P0CG48 source Swiss-Prot : SWS_FT_FI5 44) chain D residue 29 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000250|UniProtKB:P0CG48 source Swiss-Prot : SWS_FT_FI5 45) chain D residue 33 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000250|UniProtKB:P0CG48 source Swiss-Prot : SWS_FT_FI5 46) chain D residue 48 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000250|UniProtKB:P0CG48 source Swiss-Prot : SWS_FT_FI5 47) chain D residue 63 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000250|UniProtKB:P0CG48 source Swiss-Prot : SWS_FT_FI5 48) chain E residue 6 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000250|UniProtKB:P0CG48 source Swiss-Prot : SWS_FT_FI5 49) chain A residue 27 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000250|UniProtKB:P0CG48 source Swiss-Prot : SWS_FT_FI5 50) chain E residue 11 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000250|UniProtKB:P0CG48 source Swiss-Prot : SWS_FT_FI5 51) chain E residue 27 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000250|UniProtKB:P0CG48 source Swiss-Prot : SWS_FT_FI5 52) chain E residue 29 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000250|UniProtKB:P0CG48 source Swiss-Prot : SWS_FT_FI5 53) chain E residue 33 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000250|UniProtKB:P0CG48 source Swiss-Prot : SWS_FT_FI5 54) chain E residue 48 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000250|UniProtKB:P0CG48 source Swiss-Prot : SWS_FT_FI5 55) chain E residue 63 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000250|UniProtKB:P0CG48 source Swiss-Prot : SWS_FT_FI5 56) chain F residue 6 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000250|UniProtKB:P0CG48 source Swiss-Prot : SWS_FT_FI5 57) chain F residue 11 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000250|UniProtKB:P0CG48 source Swiss-Prot : SWS_FT_FI5 58) chain F residue 27 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000250|UniProtKB:P0CG48 source Swiss-Prot : SWS_FT_FI5 59) chain F residue 29 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000250|UniProtKB:P0CG48 source Swiss-Prot : SWS_FT_FI5 60) chain A residue 29 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000250|UniProtKB:P0CG48 source Swiss-Prot : SWS_FT_FI5 61) chain F residue 33 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000250|UniProtKB:P0CG48 source Swiss-Prot : SWS_FT_FI5 62) chain F residue 48 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000250|UniProtKB:P0CG48 source Swiss-Prot : SWS_FT_FI5 63) chain F residue 63 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000250|UniProtKB:P0CG48 source Swiss-Prot : SWS_FT_FI5 64) chain A residue 33 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000250|UniProtKB:P0CG48 source Swiss-Prot : SWS_FT_FI5 65) chain A residue 48 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000250|UniProtKB:P0CG48 source Swiss-Prot : SWS_FT_FI5 66) chain A residue 63 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000250|UniProtKB:P0CG48 source Swiss-Prot : SWS_FT_FI5 67) chain B residue 6 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000250|UniProtKB:P0CG48 source Swiss-Prot : SWS_FT_FI5 68) chain B residue 11 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000250|UniProtKB:P0CG48 source Swiss-Prot : SWS_FT_FI5 69) chain E residue 76 type CROSSLNK sequence G description Glycyl lysine isopeptide (Gly-Lys) (interchain with K-? in acceptor proteins) => ECO:0000255|PROSITE-ProRule:PRU00214 source Swiss-Prot : SWS_FT_FI6 70) chain A residue 76 type CROSSLNK sequence G description Glycyl lysine isopeptide (Gly-Lys) (interchain with K-? in acceptor proteins) => ECO:0000255|PROSITE-ProRule:PRU00214 source Swiss-Prot : SWS_FT_FI6 71) chain C residue 76 type CROSSLNK sequence G description Glycyl lysine isopeptide (Gly-Lys) (interchain with K-? in acceptor proteins) => ECO:0000255|PROSITE-ProRule:PRU00214 source Swiss-Prot : SWS_FT_FI6 72) chain A residue 54 type SITE sequence R description Interacts with activating enzyme source Swiss-Prot : SWS_FT_FI1 73) chain E residue 72 type SITE sequence R description Interacts with activating enzyme source Swiss-Prot : SWS_FT_FI1 74) chain F residue 54 type SITE sequence R description Interacts with activating enzyme source Swiss-Prot : SWS_FT_FI1 75) chain F residue 72 type SITE sequence R description Interacts with activating enzyme source Swiss-Prot : SWS_FT_FI1 76) chain A residue 72 type SITE sequence R description Interacts with activating enzyme source Swiss-Prot : SWS_FT_FI1 77) chain B residue 54 type SITE sequence R description Interacts with activating enzyme source Swiss-Prot : SWS_FT_FI1 78) chain B residue 72 type SITE sequence R description Interacts with activating enzyme source Swiss-Prot : SWS_FT_FI1 79) chain C residue 54 type SITE sequence R description Interacts with activating enzyme source Swiss-Prot : SWS_FT_FI1 80) chain C residue 72 type SITE sequence R description Interacts with activating enzyme source Swiss-Prot : SWS_FT_FI1 81) chain D residue 54 type SITE sequence R description Interacts with activating enzyme source Swiss-Prot : SWS_FT_FI1 82) chain D residue 72 type SITE sequence R description Interacts with activating enzyme source Swiss-Prot : SWS_FT_FI1 83) chain E residue 54 type SITE sequence R description Interacts with activating enzyme source Swiss-Prot : SWS_FT_FI1 84) chain A residue 68 type SITE sequence H description Essential for function source Swiss-Prot : SWS_FT_FI2 85) chain B residue 68 type SITE sequence H description Essential for function source Swiss-Prot : SWS_FT_FI2 86) chain C residue 68 type SITE sequence H description Essential for function source Swiss-Prot : SWS_FT_FI2 87) chain D residue 68 type SITE sequence H description Essential for function source Swiss-Prot : SWS_FT_FI2 88) chain E residue 68 type SITE sequence H description Essential for function source Swiss-Prot : SWS_FT_FI2 89) chain F residue 68 type SITE sequence H description Essential for function source Swiss-Prot : SWS_FT_FI2 90) chain A residue 27-52 type prosite sequence KAKIQDKEGIPPDQQRLIFAGKQLED description UBIQUITIN_1 Ubiquitin domain signature. KakIqDkegIPpdqQrLIFaGkqleD source prosite : PS00299

Display surface Download Links