eF-site ID 3m17-ABCDEFGH
PDB Code 3m17
Chain A, B, C, D, E, F, G, H

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Title Crystal structure of human FcRn with a monomeric peptide inhibitor
Classification IMMUNE SYSTEM/INHIBITOR
Compound IgG receptor FcRn large subunit p51
Source Homo sapiens (Human) (3M17)
Sequence A:  LSLLYHLTAVSSPAPGTPAFWVSGWLGPQQYLSYNSLRGE
AEPCGAWVWENQVSWYWEKETTDLRIKEKLFLEAFKALGG
KGPYTLQGLLGCELGPDNTSVPTAKFALNGEEFMNFDLKQ
GTWGGDWPEALAISQRWQQQDKAANKELTFLLFSCPHRLR
EHLERGRGNLEWKEPPSMRLKARPSSPGFSVLTCSAFSFY
PPELQLRFLRNGLAAGTGQGDFGPNSDGSFHASSSLTVKS
GDEHHYCCIVQHAGLAQPLRVEL
B:  IQRTPKIQVYSRHPAENGKSNFLNCYVSGFHPSDIEVDLL
KNGERIEKVEHSDLSFSKDWSFYLLYYTEFTPTEKDEYAC
RVNHVTLSQPKIVKWDRDM
C:  LSLLYHLTAVSSPAPGTPAFWVSGWLGPQQYLSYNSLRGE
AEPCGAWVWENQVSWYWEKETTDLRIKEKLFLEAFKALGG
KGPYTLQGLLGCELGPDNTSVPTAKFALNGEEFMNFDLKQ
GTWGGDWPEALAISQRWQQQDKAANKELTFLLFSCPHRLR
EHLERGRGNLEWKEPPSMRLKARPSSPGFSVLTCSAFSFY
PPELQLRFLRNGLAAGTGQGDFGPNSDGSFHASSSLTVKS
GDEHHYCCIVQHAGLAQPLRVEL
D:  IQRTPKIQVYSRHPAENGKSNFLNCYVSGFHPSDIEVDLL
KNGERIEKVEHSDLSFSKDWSFYLLYYTEFTPTEKDEYAC
RVNHVTLSQPKIVKWDRDM
E:  LSLLYHLTAVSSPAPGTPAFWVSGWLGPQQYLSYNSLRGE
AEPCGAWVWENQVSWYWEKETTDLRIKEKLFLEAFKALGG
KGPYTLQGLLGCELGPDNTSVPTAKFALNGEEFMNFDLKQ
GTWGGDWPEALAISQRWQQQDKAANKELTFLLFSCPHRLR
EHLERGRGNLEWKEPPSMRLKARPSSPGFSVLTCSAFSFY
PPELQLRFLRNGLAAGTGQGDFGPNSDGSFHASSSLTVKS
GDEHHYCCIVQHAGLAQPLRVEL
F:  IQRTPKIQVYSRHPAENGKSNFLNCYVSGFHPSDIEVDLL
KNGERIEKVEHSDLSFSKDWSFYLLYYTEFTPTEKDEYAC
RVNHVTLSQPKIVKWDRDM
G:  LSLLYHLTAVSSPAPGTPAFWVSGWLGPQQYLSYNSLRGE
AEPCGAWVWENQVSWYWEKETTDLRIKEKLFLEAFKALGG
KGPYTLQGLLGCELGPDNTSVPTAKFALNGEEFMNFDLKQ
GTWGGDWPEALAISQRWQQQDKAANKELTFLLFSCPHRLR
EHLERGRGNLEWKEPPSMRLKARPSSPGFSVLTCSAFSFY
PPELQLRFLRNGLAAGTGQGDFGPNSDGSFHASSSLTVKS
GDEHHYCCIVQHAGLAQPLRVEL
H:  IQRTPKIQVYSRHPAENGKSNFLNCYVSGFHPSDIEVDLL
KNGERIEKVEHSDLSFSKDWSFYLLYYTEFTPTEKDEYAC
RVNHVTLSQPKIVKWDRDM
Description


Functional site

1) chain B
residue 2
type MOD_RES
sequence Q
description Pyrrolidone carboxylic acid; in form pI 5.3 => ECO:0000269|PubMed:7554280
source Swiss-Prot : SWS_FT_FI1

2) chain D
residue 2
type MOD_RES
sequence Q
description Pyrrolidone carboxylic acid; in form pI 5.3 => ECO:0000269|PubMed:7554280
source Swiss-Prot : SWS_FT_FI1

3) chain F
residue 2
type MOD_RES
sequence Q
description Pyrrolidone carboxylic acid; in form pI 5.3 => ECO:0000269|PubMed:7554280
source Swiss-Prot : SWS_FT_FI1

4) chain H
residue 2
type MOD_RES
sequence Q
description Pyrrolidone carboxylic acid; in form pI 5.3 => ECO:0000269|PubMed:7554280
source Swiss-Prot : SWS_FT_FI1

5) chain B
residue 1
type CARBOHYD
sequence I
description N-linked (Glc) (glycation) isoleucine; in hemodialysis-associated amyloidosis => ECO:0000269|PubMed:7918443
source Swiss-Prot : SWS_FT_FI2

6) chain D
residue 1
type CARBOHYD
sequence I
description N-linked (Glc) (glycation) isoleucine; in hemodialysis-associated amyloidosis => ECO:0000269|PubMed:7918443
source Swiss-Prot : SWS_FT_FI2

7) chain F
residue 1
type CARBOHYD
sequence I
description N-linked (Glc) (glycation) isoleucine; in hemodialysis-associated amyloidosis => ECO:0000269|PubMed:7918443
source Swiss-Prot : SWS_FT_FI2

8) chain H
residue 1
type CARBOHYD
sequence I
description N-linked (Glc) (glycation) isoleucine; in hemodialysis-associated amyloidosis => ECO:0000269|PubMed:7918443
source Swiss-Prot : SWS_FT_FI2

9) chain B
residue 19
type CARBOHYD
sequence K
description N-linked (Glc) (glycation) lysine; in vitro => ECO:0000269|PubMed:7918443
source Swiss-Prot : SWS_FT_FI3

10) chain D
residue 58
type CARBOHYD
sequence K
description N-linked (Glc) (glycation) lysine; in vitro => ECO:0000269|PubMed:7918443
source Swiss-Prot : SWS_FT_FI3

11) chain D
residue 91
type CARBOHYD
sequence K
description N-linked (Glc) (glycation) lysine; in vitro => ECO:0000269|PubMed:7918443
source Swiss-Prot : SWS_FT_FI3

12) chain D
residue 94
type CARBOHYD
sequence K
description N-linked (Glc) (glycation) lysine; in vitro => ECO:0000269|PubMed:7918443
source Swiss-Prot : SWS_FT_FI3

13) chain F
residue 19
type CARBOHYD
sequence K
description N-linked (Glc) (glycation) lysine; in vitro => ECO:0000269|PubMed:7918443
source Swiss-Prot : SWS_FT_FI3

14) chain F
residue 41
type CARBOHYD
sequence K
description N-linked (Glc) (glycation) lysine; in vitro => ECO:0000269|PubMed:7918443
source Swiss-Prot : SWS_FT_FI3

15) chain F
residue 48
type CARBOHYD
sequence K
description N-linked (Glc) (glycation) lysine; in vitro => ECO:0000269|PubMed:7918443
source Swiss-Prot : SWS_FT_FI3

16) chain F
residue 58
type CARBOHYD
sequence K
description N-linked (Glc) (glycation) lysine; in vitro => ECO:0000269|PubMed:7918443
source Swiss-Prot : SWS_FT_FI3

17) chain F
residue 91
type CARBOHYD
sequence K
description N-linked (Glc) (glycation) lysine; in vitro => ECO:0000269|PubMed:7918443
source Swiss-Prot : SWS_FT_FI3

18) chain F
residue 94
type CARBOHYD
sequence K
description N-linked (Glc) (glycation) lysine; in vitro => ECO:0000269|PubMed:7918443
source Swiss-Prot : SWS_FT_FI3

19) chain H
residue 19
type CARBOHYD
sequence K
description N-linked (Glc) (glycation) lysine; in vitro => ECO:0000269|PubMed:7918443
source Swiss-Prot : SWS_FT_FI3

20) chain B
residue 41
type CARBOHYD
sequence K
description N-linked (Glc) (glycation) lysine; in vitro => ECO:0000269|PubMed:7918443
source Swiss-Prot : SWS_FT_FI3

21) chain H
residue 41
type CARBOHYD
sequence K
description N-linked (Glc) (glycation) lysine; in vitro => ECO:0000269|PubMed:7918443
source Swiss-Prot : SWS_FT_FI3

22) chain H
residue 48
type CARBOHYD
sequence K
description N-linked (Glc) (glycation) lysine; in vitro => ECO:0000269|PubMed:7918443
source Swiss-Prot : SWS_FT_FI3

23) chain H
residue 58
type CARBOHYD
sequence K
description N-linked (Glc) (glycation) lysine; in vitro => ECO:0000269|PubMed:7918443
source Swiss-Prot : SWS_FT_FI3

24) chain H
residue 91
type CARBOHYD
sequence K
description N-linked (Glc) (glycation) lysine; in vitro => ECO:0000269|PubMed:7918443
source Swiss-Prot : SWS_FT_FI3

25) chain H
residue 94
type CARBOHYD
sequence K
description N-linked (Glc) (glycation) lysine; in vitro => ECO:0000269|PubMed:7918443
source Swiss-Prot : SWS_FT_FI3

26) chain B
residue 48
type CARBOHYD
sequence K
description N-linked (Glc) (glycation) lysine; in vitro => ECO:0000269|PubMed:7918443
source Swiss-Prot : SWS_FT_FI3

27) chain B
residue 58
type CARBOHYD
sequence K
description N-linked (Glc) (glycation) lysine; in vitro => ECO:0000269|PubMed:7918443
source Swiss-Prot : SWS_FT_FI3

28) chain B
residue 91
type CARBOHYD
sequence K
description N-linked (Glc) (glycation) lysine; in vitro => ECO:0000269|PubMed:7918443
source Swiss-Prot : SWS_FT_FI3

29) chain B
residue 94
type CARBOHYD
sequence K
description N-linked (Glc) (glycation) lysine; in vitro => ECO:0000269|PubMed:7918443
source Swiss-Prot : SWS_FT_FI3

30) chain D
residue 19
type CARBOHYD
sequence K
description N-linked (Glc) (glycation) lysine; in vitro => ECO:0000269|PubMed:7918443
source Swiss-Prot : SWS_FT_FI3

31) chain D
residue 41
type CARBOHYD
sequence K
description N-linked (Glc) (glycation) lysine; in vitro => ECO:0000269|PubMed:7918443
source Swiss-Prot : SWS_FT_FI3

32) chain D
residue 48
type CARBOHYD
sequence K
description N-linked (Glc) (glycation) lysine; in vitro => ECO:0000269|PubMed:7918443
source Swiss-Prot : SWS_FT_FI3

33) chain A
residue 250-256
type prosite
sequence YCCIVQH
description IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YCCIVQH
source prosite : PS00290

34) chain B
residue 78-84
type prosite
sequence YACRVNH
description IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YCCIVQH
source prosite : PS00290


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