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eF-site ID
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3lww-C |
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PDB Code
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3lww |
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Chain
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C |
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click to enlarge
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Title
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Structure of an open and closed conformation of Human Importin Beta bound to the Snurportin1 IBB-domain trapped in the same crystallographic asymmetric unit |
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Classification
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PROTEIN TRANSPORT |
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Compound
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Importin subunit beta-1 |
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Source
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Homo sapiens (Human) (SPN1_HUMAN) |
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Sequence
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C: |
MELITILEKTVSPDRLELEAAQKFLERAAVENLPTFLVEL
SRVLANPGNSQVARVAAGLQIKNSLTSKDPDIKAQYQQRW
LAIDANARREVKNYVLQTLGTETYRPSSASQCVAGIACAE
IPVNQWPELIPQLVANVTNPNSTEHMKESTLEAIGYICQD
IDPEQLQDKSNEILTAIIQGMRKEEPSNNVKLAATNALLN
SLEFTKANFDKESERHFIMQVVCEATQCPDTRVRVAALQN
LVKIMSLYYQYMETYMGPALFAITIEAMKSDIDEVALQGI
EFWSNVCDEEMDLAIEASEAAEQGRPPEHTSKFYAKGALQ
YLVPILTQTLTKQDENDDDDDWNPCKAAGVCLMLLATCCE
DDIVPHVLPFIKEHIKNPDWRYRDAAVMAFGCILEGPEPS
QLKPLVIQAMPTLIELMKDPSVVVRDTAAWTVGRICELLP
EAAINDVYLAPLLQCLIEGLSARVASNVCWAFSSLAEAAY
EAADVADDQEEPATYCLSSSFELIVQKLLETTDRPDGHQN
NLRSSAYESLMEIVKNSAKDCYPAVQKTTLVIMERLQQVL
QMESHIQSTSDRIQFNDLQSLLCATLQNVLRKVQHQDALQ
ISDVVMASLLRMFQSTAGSGGVQEDALMAVSTLVEVLGGE
FLKYMEAFKPFLGIGLKNYAEYQVCLAAVGLVGDLCRALQ
SNIIPFCDEVMQLLLENLGNENVHRSVKPQILSVFGDIAL
AIGGEFKKYLEVVLNTLQQASQAQVDKSDYDMVDYLNELR
ESCLEAYTGIVQGLKGDQENVHPDVMLVQPRVEFILSFID
HIAGDEDHTDGVVACAAGLIGDLCTAFGKDVLKLVEARPM
IHELLTEGRRSKTNKAKTLATWATKELRKLK
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Description
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Functional site
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|
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1)
|
chain |
C |
| residue |
1 |
| type |
MOD_RES |
| sequence |
M
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| description |
N-acetylmethionine => ECO:0000269|Ref.9, ECO:0007744|PubMed:19413330, ECO:0007744|PubMed:22223895, ECO:0007744|PubMed:22814378, ECO:0007744|PubMed:25944712
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| source |
Swiss-Prot : SWS_FT_FI1
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2)
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chain |
C |
| residue |
12 |
| type |
MOD_RES |
| sequence |
S
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| description |
Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:23186163
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| source |
Swiss-Prot : SWS_FT_FI2
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|
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3)
|
chain |
C |
| residue |
211 |
| type |
MOD_RES |
| sequence |
K
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| description |
N6-acetyllysine => ECO:0007744|PubMed:19608861
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| source |
Swiss-Prot : SWS_FT_FI3
|
|
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4)
|
chain |
C |
| residue |
835 |
| type |
MOD_RES |
| sequence |
K
|
| description |
N6-acetyllysine => ECO:0007744|PubMed:19608861
|
| source |
Swiss-Prot : SWS_FT_FI3
|
|
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5)
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chain |
C |
| residue |
867 |
| type |
MOD_RES |
| sequence |
K
|
| description |
N6-acetyllysine => ECO:0007744|PubMed:19608861
|
| source |
Swiss-Prot : SWS_FT_FI3
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