eF-site ID 3lrs-ABCDEFHL PDB Code 3lrs Chain A, B, C, D, E, F, H, L click to enlarge Title Structure of PG16, an antibody with broad and potent neutralization of HIV-1 Classification IMMUNE SYSTEM Compound PG-16 Heavy Chain Fab Source (3LRS) Sequence A:  QEQLVESGGGVVQPGGSLRLSCLASGFTFHKYGMHWVRQA PGKGLEWVALISDDGMRKYHSDSMWGRVTISRDNSKNTLY LQFSSLKVEDTAMFFCAREAGGPYYNYHYMDVWGKGTTVT VSSASTKGPSVFPLAPSSKSGGTAALGCLVKDYFPEPVTV SWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQ TYICNVNHKPSNTKVDKRVEP B:  ALTQPASVSGSPGQTITISCNGTSSDVGGFDSVSWYQQSP GKAPKVMVFDVSHRPSGISNRFSGSKSGNTASLTISGLHI EDEGDYFCSSLTDRSHRIFGGGTKVTVLGQPKAAPSVTLF PPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAG VETTTPSKQSNNKYAASSYLSLTPEQWKSHKSYSCQVTHE GSTVEKTVAPT C:  QEQLVESGGGVVQPGGSLRLSCLASGFTFHKYGMHWVRQA PGKGLEWVALISDDGMRKYHSDSMWGRVTISRDNSKNTLY LQFSSLKVEDTAMFFCAREAGGPINDGYYNYHYMDVWGKG TTVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYF PEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPS SSLGTQTYICNVNHKPSNTKVDKRVEPK D:  ALTQPASVSGSPGQTITISCNGTSSDVGGFDSVSWYQQSP GKAPKVMVFDVSHRPSGISNRFSGSKSGNTASLTISGLHI EDEGDYFCSSLTDRSHRIFGGGTKVTVLGQPKAAPSVTLF PPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAG VETTTPSKQSNNKYAASSYLSLTPEQWKSHKSYSCQVTHE GSTVEKTVAPT E:  QEQLVESGGGVVQPGGSLRLSCLASGFTFHKYGMHWVRQA PGKGLEWVALISDDGMRKYHSDSMWGRVTISRDNSKNTLY LQFSSLKVEDTAMFFCAREAGGPINDGYYNYHYMDVWGKG TTVTVSSASTKGPSVFPLAPSSTAALGCLVKDYFPEPVTV SWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQ TYICNVNHKPSNTKVDKRVEP F:  ALTQPASVSGSPGQTITISCNGTSSDVGGFDSVSWYQQSP GKAPKVMVFDVSHRPSGISNRFSGSKSGNTASLTISGLHI EDEGDYFCSSLTDRSHRIFGGGTKVTVLGQPKAAPSVTLF PPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAG VETTTPSKQSNNKYAASSYLSLTPEQWKSHKSYSCQVTHE GSTVEKTVAPT H:  QEQLVESGGGVVQPGGSLRLSCLASGFTFHKYGMHWVRQA PGKGLEWVALISDDGMRKYHSDSMWGRVTISRDNSKNTLY LQFSSLKVEDTAMFFCAREAGGPYYNYHYMDVWGKGTTVT VSSASTKGPSVFPLAPSSKGGTAALGCLVKDYFPEPVTVS WNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQT YICNVNHKPSNTKVDKRVEP L:  ALTQPASVSGSPGQTITISCNGTSSDVGGFDSVSWYQQSP GKAPKVMVFDVSHRPSGISNRFSGSKSGNTASLTISGLHI EDEGDYFCSSLTDRSHRIFGGGTKVTVLGQPKAAPSVTLF PPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAG VETTTPSKQSNNKYAASSYLSLTPEQWKSHKSYSCQVTHE GSTVEKTVAPT Description Functional site 1) chain H residue 194-200 type prosite sequence YICNVNH description IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YICNVNH source prosite : PS00290 2) chain L residue 191-197 type prosite sequence YSCQVTH description IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YICNVNH source prosite : PS00290

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