eF-site ID 3lkz-B PDB Code 3lkz Chain B click to enlarge Title Structural and functional analyses of a conserved hydrophobic pocket of flavivirus methyltransferase Classification VIRAL PROTEIN Compound Non-structural protein 5 Source West Nile virus (WNV) (Q9Q6P4_WNV) Sequence B:  GRTLGEVWKERLNQMTKEEFTRYRKEAIIEVDRSAAKHAR KEGNVTGGHPVSRGTAKLRWLVERRFLEPVGKVIDLGCGR GGWCYYMATQKRVQEVRGYTKGGPGHEEPQLVQSYGWNIV TMKSGVDVFYRPSECCDTLLCDIGESSSSAEVEEHRTIRV LEMVEDWLHRGPREFCVKVLCPYMPKVIEKMELLQRRYGG GLVRNPLSRNSTHEMYWVSRASGNVVHSVNMTSQVLLGRM EKRTWKGPQYEEDVNLGSGTRA Description Functional site 1) chain B residue 200 type sequence R description BINDING SITE FOR RESIDUE SFG A 301 source : AC1 2) chain B residue 177 type sequence R description BINDING SITE FOR RESIDUE GOL A 302 source : AC2 3) chain B residue 56 type sequence S description BINDING SITE FOR RESIDUE SFG B 301 source : AC3 4) chain B residue 58 type sequence G description BINDING SITE FOR RESIDUE SFG B 301 source : AC3 5) chain B residue 81 type sequence G description BINDING SITE FOR RESIDUE SFG B 301 source : AC3 6) chain B residue 82 type sequence C description BINDING SITE FOR RESIDUE SFG B 301 source : AC3 7) chain B residue 83 type sequence G description BINDING SITE FOR RESIDUE SFG B 301 source : AC3 8) chain B residue 86 type sequence G description BINDING SITE FOR RESIDUE SFG B 301 source : AC3 9) chain B residue 87 type sequence W description BINDING SITE FOR RESIDUE SFG B 301 source : AC3 10) chain B residue 104 type sequence T description BINDING SITE FOR RESIDUE SFG B 301 source : AC3 11) chain B residue 105 type sequence K description BINDING SITE FOR RESIDUE SFG B 301 source : AC3 12) chain B residue 110 type sequence H description BINDING SITE FOR RESIDUE SFG B 301 source : AC3 13) chain B residue 111 type sequence E description BINDING SITE FOR RESIDUE SFG B 301 source : AC3 14) chain B residue 130 type sequence V description BINDING SITE FOR RESIDUE SFG B 301 source : AC3 15) chain B residue 131 type sequence D description BINDING SITE FOR RESIDUE SFG B 301 source : AC3 16) chain B residue 132 type sequence V description BINDING SITE FOR RESIDUE SFG B 301 source : AC3 17) chain B residue 133 type sequence F description BINDING SITE FOR RESIDUE SFG B 301 source : AC3 18) chain B residue 146 type sequence D description BINDING SITE FOR RESIDUE SFG B 301 source : AC3 19) chain B residue 149 type sequence E description BINDING SITE FOR RESIDUE SFG B 301 source : AC3 20) chain B residue 159 type sequence H description BINDING SITE FOR RESIDUE GOL B 302 source : AC4 21) chain B residue 246 type sequence K description BINDING SITE FOR RESIDUE GOL B 302 source : AC4 22) chain B residue 247 type sequence R description BINDING SITE FOR RESIDUE GOL B 302 source : AC4 23) chain B residue 248 type sequence T description BINDING SITE FOR RESIDUE GOL B 302 source : AC4 24) chain B residue 56 type MOD_RES sequence S description Phosphoserine => ECO:0000250|UniProtKB:P03314 source Swiss-Prot : SWS_FT_FI11 25) chain B residue 61 type ACT_SITE sequence K description For 2'-O-MTase activity => ECO:0000269|PubMed:17267492 source Swiss-Prot : SWS_FT_FI1 26) chain B residue 146 type ACT_SITE sequence D description For 2'-O-MTase activity => ECO:0000269|PubMed:17267492 source Swiss-Prot : SWS_FT_FI1 27) chain B residue 182 type ACT_SITE sequence K description For 2'-O-MTase activity => ECO:0000269|PubMed:17267492 source Swiss-Prot : SWS_FT_FI1 28) chain B residue 218 type ACT_SITE sequence E description For 2'-O-MTase activity => ECO:0000269|PubMed:17267492 source Swiss-Prot : SWS_FT_FI1 29) chain B residue 16 type SITE sequence L description mRNA cap binding; via carbonyl oxygen => ECO:0000255|PROSITE-ProRule:PRU00924 source Swiss-Prot : SWS_FT_FI7 30) chain B residue 19 type SITE sequence M description mRNA cap binding; via carbonyl oxygen => ECO:0000255|PROSITE-ProRule:PRU00924 source Swiss-Prot : SWS_FT_FI7 31) chain B residue 24 type SITE sequence F description mRNA cap binding => ECO:0000255|PROSITE-ProRule:PRU00924, ECO:0000269|PubMed:17267492 source Swiss-Prot : SWS_FT_FI8 32) chain B residue 61 type SITE sequence K description Essential for 2'-O-methyltransferase activity => ECO:0000255|PROSITE-ProRule:PRU00924 source Swiss-Prot : SWS_FT_FI9 33) chain B residue 182 type SITE sequence K description Essential for 2'-O-methyltransferase activity => ECO:0000255|PROSITE-ProRule:PRU00924 source Swiss-Prot : SWS_FT_FI9 34) chain B residue 218 type SITE sequence E description Essential for 2'-O-methyltransferase activity => ECO:0000255|PROSITE-ProRule:PRU00924 source Swiss-Prot : SWS_FT_FI9 35) chain B residue 86 type BINDING sequence G description BINDING => ECO:0000255|PROSITE-ProRule:PRU00924, ECO:0007744|PDB:2OY0 source Swiss-Prot : SWS_FT_FI3 36) chain B residue 87 type BINDING sequence W description BINDING => ECO:0000255|PROSITE-ProRule:PRU00924, ECO:0007744|PDB:2OY0 source Swiss-Prot : SWS_FT_FI3 37) chain B residue 131 type BINDING sequence D description BINDING => ECO:0000255|PROSITE-ProRule:PRU00924, ECO:0007744|PDB:2OY0 source Swiss-Prot : SWS_FT_FI3 38) chain B residue 132 type BINDING sequence V description BINDING => ECO:0000255|PROSITE-ProRule:PRU00924, ECO:0007744|PDB:2OY0 source Swiss-Prot : SWS_FT_FI3 39) chain B residue 104 type BINDING sequence T description BINDING => ECO:0000255|PROSITE-ProRule:PRU00924 source Swiss-Prot : SWS_FT_FI4 40) chain B residue 105 type BINDING sequence K description BINDING => ECO:0000255|PROSITE-ProRule:PRU00924 source Swiss-Prot : SWS_FT_FI4 41) chain B residue 147 type BINDING sequence I description BINDING => ECO:0000255|PROSITE-ProRule:PRU00924 source Swiss-Prot : SWS_FT_FI4 42) chain B residue 220 type BINDING sequence Y description BINDING => ECO:0000255|PROSITE-ProRule:PRU00924 source Swiss-Prot : SWS_FT_FI4 43) chain B residue 111 type BINDING sequence E description BINDING => ECO:0000269|PubMed:17267492 source Swiss-Prot : SWS_FT_FI5 44) chain B residue 146 type BINDING sequence D description BINDING => ECO:0000269|PubMed:17267492 source Swiss-Prot : SWS_FT_FI5 45) chain B residue 150 type SITE sequence S description mRNA cap binding => ECO:0000255|PROSITE-ProRule:PRU00924 source Swiss-Prot : SWS_FT_FI6 46) chain B residue 213 type SITE sequence R description mRNA cap binding => ECO:0000255|PROSITE-ProRule:PRU00924 source Swiss-Prot : SWS_FT_FI6 47) chain B residue 215 type SITE sequence S description mRNA cap binding => ECO:0000255|PROSITE-ProRule:PRU00924 source Swiss-Prot : SWS_FT_FI6 48) chain B residue 13 type SITE sequence K description mRNA cap binding => ECO:0000255|PROSITE-ProRule:PRU00924 source Swiss-Prot : SWS_FT_FI6 49) chain B residue 17 type SITE sequence N description mRNA cap binding => ECO:0000255|PROSITE-ProRule:PRU00924 source Swiss-Prot : SWS_FT_FI6 50) chain B residue 28 type SITE sequence R description mRNA cap binding => ECO:0000255|PROSITE-ProRule:PRU00924 source Swiss-Prot : SWS_FT_FI6 51) chain B residue 146 type SITE sequence D description Essential for 2'-O-methyltransferase and N-7 methyltransferase activity => ECO:0000255|PROSITE-ProRule:PRU00924 source Swiss-Prot : SWS_FT_FI10 52) chain B residue 56 type BINDING sequence S description BINDING => ECO:0000255|PROSITE-ProRule:PRU00924, ECO:0000269|PubMed:17267492 source Swiss-Prot : SWS_FT_FI2

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