eF-site ID 3lkz-A PDB Code 3lkz Chain A click to enlarge Title Structural and functional analyses of a conserved hydrophobic pocket of flavivirus methyltransferase Classification VIRAL PROTEIN Compound Non-structural protein 5 Source West Nile virus (WNV) (Q9Q6P4_WNV) Sequence A:  GRTLGEVWKERLNQMTKEEFTRYRKEAIIEVDRSAAKHAR KEGNVTGGHPVSRGTAKLRWLVERRFLEPVGKVIDLGCGR GGWCYYMATQKRVQEVRGYTKGGPGHEEPQLVQSYGWNIV TMKSGVDVFYRPSECCDTLLCDIGESSSSAEVEEHRTIRV LEMVEDWLHRGPREFCVKVLCPYMPKVIEKMELLQRRYGG GLVRNPLSRNSTHEMYWVSRASGNVVHSVNMTSQVLLGRM EKRTWKGPQYEEDVNLGSGTRA Description Functional site 1) chain A residue 56 type sequence S description BINDING SITE FOR RESIDUE SFG A 301 source : AC1 2) chain A residue 58 type sequence G description BINDING SITE FOR RESIDUE SFG A 301 source : AC1 3) chain A residue 81 type sequence G description BINDING SITE FOR RESIDUE SFG A 301 source : AC1 4) chain A residue 82 type sequence C description BINDING SITE FOR RESIDUE SFG A 301 source : AC1 5) chain A residue 83 type sequence G description BINDING SITE FOR RESIDUE SFG A 301 source : AC1 6) chain A residue 86 type sequence G description BINDING SITE FOR RESIDUE SFG A 301 source : AC1 7) chain A residue 87 type sequence W description BINDING SITE FOR RESIDUE SFG A 301 source : AC1 8) chain A residue 105 type sequence K description BINDING SITE FOR RESIDUE SFG A 301 source : AC1 9) chain A residue 110 type sequence H description BINDING SITE FOR RESIDUE SFG A 301 source : AC1 10) chain A residue 111 type sequence E description BINDING SITE FOR RESIDUE SFG A 301 source : AC1 11) chain A residue 130 type sequence V description BINDING SITE FOR RESIDUE SFG A 301 source : AC1 12) chain A residue 131 type sequence D description BINDING SITE FOR RESIDUE SFG A 301 source : AC1 13) chain A residue 132 type sequence V description BINDING SITE FOR RESIDUE SFG A 301 source : AC1 14) chain A residue 133 type sequence F description BINDING SITE FOR RESIDUE SFG A 301 source : AC1 15) chain A residue 146 type sequence D description BINDING SITE FOR RESIDUE SFG A 301 source : AC1 16) chain A residue 147 type sequence I description BINDING SITE FOR RESIDUE SFG A 301 source : AC1 17) chain A residue 149 type sequence E description BINDING SITE FOR RESIDUE SFG A 301 source : AC1 18) chain A residue 159 type sequence H description BINDING SITE FOR RESIDUE GOL A 302 source : AC2 19) chain A residue 246 type sequence K description BINDING SITE FOR RESIDUE GOL A 302 source : AC2 20) chain A residue 247 type sequence R description BINDING SITE FOR RESIDUE GOL A 302 source : AC2 21) chain A residue 248 type sequence T description BINDING SITE FOR RESIDUE GOL A 302 source : AC2 22) chain A residue 200 type sequence R description BINDING SITE FOR RESIDUE SFG B 301 source : AC3 23) chain A residue 177 type sequence R description BINDING SITE FOR RESIDUE GOL B 302 source : AC4 24) chain A residue 56 type MOD_RES sequence S description Phosphoserine => ECO:0000250|UniProtKB:P03314 source Swiss-Prot : SWS_FT_FI11 25) chain A residue 61 type ACT_SITE sequence K description For 2'-O-MTase activity => ECO:0000269|PubMed:17267492 source Swiss-Prot : SWS_FT_FI1 26) chain A residue 146 type ACT_SITE sequence D description For 2'-O-MTase activity => ECO:0000269|PubMed:17267492 source Swiss-Prot : SWS_FT_FI1 27) chain A residue 182 type ACT_SITE sequence K description For 2'-O-MTase activity => ECO:0000269|PubMed:17267492 source Swiss-Prot : SWS_FT_FI1 28) chain A residue 218 type ACT_SITE sequence E description For 2'-O-MTase activity => ECO:0000269|PubMed:17267492 source Swiss-Prot : SWS_FT_FI1 29) chain A residue 16 type SITE sequence L description mRNA cap binding; via carbonyl oxygen => ECO:0000255|PROSITE-ProRule:PRU00924 source Swiss-Prot : SWS_FT_FI7 30) chain A residue 19 type SITE sequence M description mRNA cap binding; via carbonyl oxygen => ECO:0000255|PROSITE-ProRule:PRU00924 source Swiss-Prot : SWS_FT_FI7 31) chain A residue 24 type SITE sequence F description mRNA cap binding => ECO:0000255|PROSITE-ProRule:PRU00924, ECO:0000269|PubMed:17267492 source Swiss-Prot : SWS_FT_FI8 32) chain A residue 61 type SITE sequence K description Essential for 2'-O-methyltransferase activity => ECO:0000255|PROSITE-ProRule:PRU00924 source Swiss-Prot : SWS_FT_FI9 33) chain A residue 182 type SITE sequence K description Essential for 2'-O-methyltransferase activity => ECO:0000255|PROSITE-ProRule:PRU00924 source Swiss-Prot : SWS_FT_FI9 34) chain A residue 218 type SITE sequence E description Essential for 2'-O-methyltransferase activity => ECO:0000255|PROSITE-ProRule:PRU00924 source Swiss-Prot : SWS_FT_FI9 35) chain A residue 86 type BINDING sequence G description BINDING => ECO:0000255|PROSITE-ProRule:PRU00924, ECO:0007744|PDB:2OY0 source Swiss-Prot : SWS_FT_FI3 36) chain A residue 87 type BINDING sequence W description BINDING => ECO:0000255|PROSITE-ProRule:PRU00924, ECO:0007744|PDB:2OY0 source Swiss-Prot : SWS_FT_FI3 37) chain A residue 131 type BINDING sequence D description BINDING => ECO:0000255|PROSITE-ProRule:PRU00924, ECO:0007744|PDB:2OY0 source Swiss-Prot : SWS_FT_FI3 38) chain A residue 132 type BINDING sequence V description BINDING => ECO:0000255|PROSITE-ProRule:PRU00924, ECO:0007744|PDB:2OY0 source Swiss-Prot : SWS_FT_FI3 39) chain A residue 104 type BINDING sequence T description BINDING => ECO:0000255|PROSITE-ProRule:PRU00924 source Swiss-Prot : SWS_FT_FI4 40) chain A residue 105 type BINDING sequence K description BINDING => ECO:0000255|PROSITE-ProRule:PRU00924 source Swiss-Prot : SWS_FT_FI4 41) chain A residue 147 type BINDING sequence I description BINDING => ECO:0000255|PROSITE-ProRule:PRU00924 source Swiss-Prot : SWS_FT_FI4 42) chain A residue 220 type BINDING sequence Y description BINDING => ECO:0000255|PROSITE-ProRule:PRU00924 source Swiss-Prot : SWS_FT_FI4 43) chain A residue 111 type BINDING sequence E description BINDING => ECO:0000269|PubMed:17267492 source Swiss-Prot : SWS_FT_FI5 44) chain A residue 146 type BINDING sequence D description BINDING => ECO:0000269|PubMed:17267492 source Swiss-Prot : SWS_FT_FI5 45) chain A residue 13 type SITE sequence K description mRNA cap binding => ECO:0000255|PROSITE-ProRule:PRU00924 source Swiss-Prot : SWS_FT_FI6 46) chain A residue 17 type SITE sequence N description mRNA cap binding => ECO:0000255|PROSITE-ProRule:PRU00924 source Swiss-Prot : SWS_FT_FI6 47) chain A residue 28 type SITE sequence R description mRNA cap binding => ECO:0000255|PROSITE-ProRule:PRU00924 source Swiss-Prot : SWS_FT_FI6 48) chain A residue 150 type SITE sequence S description mRNA cap binding => ECO:0000255|PROSITE-ProRule:PRU00924 source Swiss-Prot : SWS_FT_FI6 49) chain A residue 213 type SITE sequence R description mRNA cap binding => ECO:0000255|PROSITE-ProRule:PRU00924 source Swiss-Prot : SWS_FT_FI6 50) chain A residue 215 type SITE sequence S description mRNA cap binding => ECO:0000255|PROSITE-ProRule:PRU00924 source Swiss-Prot : SWS_FT_FI6 51) chain A residue 146 type SITE sequence D description Essential for 2'-O-methyltransferase and N-7 methyltransferase activity => ECO:0000255|PROSITE-ProRule:PRU00924 source Swiss-Prot : SWS_FT_FI10 52) chain A residue 56 type BINDING sequence S description BINDING => ECO:0000255|PROSITE-ProRule:PRU00924, ECO:0000269|PubMed:17267492 source Swiss-Prot : SWS_FT_FI2

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