eF-site ID 3ljz-C
PDB Code 3ljz
Chain C

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Title Crystal Structure of Human MMP-13 complexed with an Amino-2-indanol compound
Classification HYDROLASE/HYDROLASE INHIBITOR
Compound Collagenase 3
Source null (MMP13_HUMAN)
Sequence C:  ANVFPRTLKWSKMNLTYRIVNYTPDMTHSEVEKAFKKAFK
VWSDVTPLNFTRLHDGIADIMISFGIKEHGDFYPFDGPSG
LLAHAFPPGPNYGGDAHFDDDETWTSSSKGYNLFLVAAHE
FGHSLGLDHSKDPGALMFPIYTYTGKSHFMLPDDDVQGIQ
SLYG
Description


Functional site

1) chain C
residue 161
type
sequence A
description BINDING SITE FOR RESIDUE CA C 996
source : BC7

2) chain C
residue 162
type
sequence D
description BINDING SITE FOR RESIDUE CA C 996
source : BC7

3) chain C
residue 194
type
sequence N
description BINDING SITE FOR RESIDUE CA C 996
source : BC7

4) chain C
residue 196
type
sequence G
description BINDING SITE FOR RESIDUE CA C 996
source : BC7

5) chain C
residue 198
type
sequence D
description BINDING SITE FOR RESIDUE CA C 996
source : BC7

6) chain C
residue 179
type
sequence D
description BINDING SITE FOR RESIDUE CA C 997
source : BC8

7) chain C
residue 180
type
sequence G
description BINDING SITE FOR RESIDUE CA C 997
source : BC8

8) chain C
residue 182
type
sequence S
description BINDING SITE FOR RESIDUE CA C 997
source : BC8

9) chain C
residue 184
type
sequence L
description BINDING SITE FOR RESIDUE CA C 997
source : BC8

10) chain C
residue 202
type
sequence D
description BINDING SITE FOR RESIDUE CA C 997
source : BC8

11) chain C
residue 205
type
sequence E
description BINDING SITE FOR RESIDUE CA C 997
source : BC8

12) chain C
residue 172
type
sequence H
description BINDING SITE FOR RESIDUE ZN C 998
source : BC9

13) chain C
residue 174
type
sequence D
description BINDING SITE FOR RESIDUE ZN C 998
source : BC9

14) chain C
residue 187
type
sequence H
description BINDING SITE FOR RESIDUE ZN C 998
source : BC9

15) chain C
residue 200
type
sequence H
description BINDING SITE FOR RESIDUE ZN C 998
source : BC9

16) chain C
residue 222
type
sequence H
description BINDING SITE FOR RESIDUE ZN C 999
source : CC1

17) chain C
residue 226
type
sequence H
description BINDING SITE FOR RESIDUE ZN C 999
source : CC1

18) chain C
residue 232
type
sequence H
description BINDING SITE FOR RESIDUE ZN C 999
source : CC1

19) chain C
residue 176
type
sequence Y
description BINDING SITE FOR RESIDUE EPE C 1
source : CC2

20) chain C
residue 184
type
sequence L
description BINDING SITE FOR RESIDUE EPE C 1
source : CC2

21) chain C
residue 187
type
sequence H
description BINDING SITE FOR RESIDUE EPE C 1
source : CC2

22) chain C
residue 188
type
sequence A
description BINDING SITE FOR RESIDUE EPE C 1
source : CC2

23) chain C
residue 189
type
sequence F
description BINDING SITE FOR RESIDUE EPE C 1
source : CC2

24) chain C
residue 190
type
sequence P
description BINDING SITE FOR RESIDUE EPE C 1
source : CC2

25) chain C
residue 120
type
sequence Y
description BINDING SITE FOR RESIDUE SO4 C 3
source : CC3

26) chain C
residue 139
type
sequence K
description BINDING SITE FOR RESIDUE SO4 C 3
source : CC3

27) chain C
residue 155
type
sequence R
description BINDING SITE FOR RESIDUE SO4 C 3
source : CC3

28) chain C
residue 115
type
sequence K
description BINDING SITE FOR RESIDUE SO4 C 7
source : CC4

29) chain C
residue 116
type
sequence M
description BINDING SITE FOR RESIDUE SO4 C 7
source : CC4

30) chain C
residue 117
type
sequence N
description BINDING SITE FOR RESIDUE SO4 C 7
source : CC4

31) chain C
residue 184
type
sequence L
description BINDING SITE FOR RESIDUE LA3 C 803
source : CC5

32) chain C
residue 185
type
sequence L
description BINDING SITE FOR RESIDUE LA3 C 803
source : CC5

33) chain C
residue 186
type
sequence A
description BINDING SITE FOR RESIDUE LA3 C 803
source : CC5

34) chain C
residue 218
type
sequence L
description BINDING SITE FOR RESIDUE LA3 C 803
source : CC5

35) chain C
residue 222
type
sequence H
description BINDING SITE FOR RESIDUE LA3 C 803
source : CC5

36) chain C
residue 223
type
sequence E
description BINDING SITE FOR RESIDUE LA3 C 803
source : CC5

37) chain C
residue 226
type
sequence H
description BINDING SITE FOR RESIDUE LA3 C 803
source : CC5

38) chain C
residue 232
type
sequence H
description BINDING SITE FOR RESIDUE LA3 C 803
source : CC5

39) chain C
residue 238
type
sequence A
description BINDING SITE FOR RESIDUE LA3 C 803
source : CC5

40) chain C
residue 239
type
sequence L
description BINDING SITE FOR RESIDUE LA3 C 803
source : CC5

41) chain C
residue 241
type
sequence F
description BINDING SITE FOR RESIDUE LA3 C 803
source : CC5

42) chain C
residue 242
type
sequence P
description BINDING SITE FOR RESIDUE LA3 C 803
source : CC5

43) chain C
residue 243
type
sequence I
description BINDING SITE FOR RESIDUE LA3 C 803
source : CC5

44) chain C
residue 244
type
sequence Y
description BINDING SITE FOR RESIDUE LA3 C 803
source : CC5

45) chain C
residue 245
type
sequence T
description BINDING SITE FOR RESIDUE LA3 C 803
source : CC5

46) chain C
residue 223
type ACT_SITE
sequence E
description ACT_SITE => ECO:0000305|PubMed:23913860
source Swiss-Prot : SWS_FT_FI1

47) chain C
residue 128
type BINDING
sequence D
description BINDING => ECO:0000269|PubMed:10926524, ECO:0000269|PubMed:10986126, ECO:0000269|PubMed:15734645, ECO:0000269|PubMed:15780611, ECO:0000269|PubMed:17196980, ECO:0000269|PubMed:17623656, ECO:0000269|PubMed:19422229, ECO:0000269|PubMed:20005097, ECO:0000269|PubMed:20726512, ECO:0000269|PubMed:22689580, ECO:0000269|PubMed:23810497, ECO:0000269|PubMed:23913860, ECO:0000269|PubMed:8969305
source Swiss-Prot : SWS_FT_FI2

48) chain C
residue 162
type BINDING
sequence D
description BINDING => ECO:0000269|PubMed:10926524, ECO:0000269|PubMed:10986126, ECO:0000269|PubMed:15734645, ECO:0000269|PubMed:15780611, ECO:0000269|PubMed:17196980, ECO:0000269|PubMed:17623656, ECO:0000269|PubMed:19422229, ECO:0000269|PubMed:20005097, ECO:0000269|PubMed:20726512, ECO:0000269|PubMed:22689580, ECO:0000269|PubMed:23810497, ECO:0000269|PubMed:23913860, ECO:0000269|PubMed:8969305
source Swiss-Prot : SWS_FT_FI2

49) chain C
residue 179
type BINDING
sequence D
description BINDING => ECO:0000269|PubMed:10926524, ECO:0000269|PubMed:10986126, ECO:0000269|PubMed:15734645, ECO:0000269|PubMed:15780611, ECO:0000269|PubMed:17196980, ECO:0000269|PubMed:17623656, ECO:0000269|PubMed:19422229, ECO:0000269|PubMed:20005097, ECO:0000269|PubMed:20726512, ECO:0000269|PubMed:22689580, ECO:0000269|PubMed:23810497, ECO:0000269|PubMed:23913860, ECO:0000269|PubMed:8969305
source Swiss-Prot : SWS_FT_FI2

50) chain C
residue 180
type BINDING
sequence G
description BINDING => ECO:0000269|PubMed:10926524, ECO:0000269|PubMed:10986126, ECO:0000269|PubMed:15734645, ECO:0000269|PubMed:15780611, ECO:0000269|PubMed:17196980, ECO:0000269|PubMed:17623656, ECO:0000269|PubMed:19422229, ECO:0000269|PubMed:20005097, ECO:0000269|PubMed:20726512, ECO:0000269|PubMed:22689580, ECO:0000269|PubMed:23810497, ECO:0000269|PubMed:23913860, ECO:0000269|PubMed:8969305
source Swiss-Prot : SWS_FT_FI2

51) chain C
residue 182
type BINDING
sequence S
description BINDING => ECO:0000269|PubMed:10926524, ECO:0000269|PubMed:10986126, ECO:0000269|PubMed:15734645, ECO:0000269|PubMed:15780611, ECO:0000269|PubMed:17196980, ECO:0000269|PubMed:17623656, ECO:0000269|PubMed:19422229, ECO:0000269|PubMed:20005097, ECO:0000269|PubMed:20726512, ECO:0000269|PubMed:22689580, ECO:0000269|PubMed:23810497, ECO:0000269|PubMed:23913860, ECO:0000269|PubMed:8969305
source Swiss-Prot : SWS_FT_FI2

52) chain C
residue 184
type BINDING
sequence L
description BINDING => ECO:0000269|PubMed:10926524, ECO:0000269|PubMed:10986126, ECO:0000269|PubMed:15734645, ECO:0000269|PubMed:15780611, ECO:0000269|PubMed:17196980, ECO:0000269|PubMed:17623656, ECO:0000269|PubMed:19422229, ECO:0000269|PubMed:20005097, ECO:0000269|PubMed:20726512, ECO:0000269|PubMed:22689580, ECO:0000269|PubMed:23810497, ECO:0000269|PubMed:23913860, ECO:0000269|PubMed:8969305
source Swiss-Prot : SWS_FT_FI2

53) chain C
residue 194
type BINDING
sequence N
description BINDING => ECO:0000269|PubMed:10926524, ECO:0000269|PubMed:10986126, ECO:0000269|PubMed:15734645, ECO:0000269|PubMed:15780611, ECO:0000269|PubMed:17196980, ECO:0000269|PubMed:17623656, ECO:0000269|PubMed:19422229, ECO:0000269|PubMed:20005097, ECO:0000269|PubMed:20726512, ECO:0000269|PubMed:22689580, ECO:0000269|PubMed:23810497, ECO:0000269|PubMed:23913860, ECO:0000269|PubMed:8969305
source Swiss-Prot : SWS_FT_FI2

54) chain C
residue 196
type BINDING
sequence G
description BINDING => ECO:0000269|PubMed:10926524, ECO:0000269|PubMed:10986126, ECO:0000269|PubMed:15734645, ECO:0000269|PubMed:15780611, ECO:0000269|PubMed:17196980, ECO:0000269|PubMed:17623656, ECO:0000269|PubMed:19422229, ECO:0000269|PubMed:20005097, ECO:0000269|PubMed:20726512, ECO:0000269|PubMed:22689580, ECO:0000269|PubMed:23810497, ECO:0000269|PubMed:23913860, ECO:0000269|PubMed:8969305
source Swiss-Prot : SWS_FT_FI2

55) chain C
residue 198
type BINDING
sequence D
description BINDING => ECO:0000269|PubMed:10926524, ECO:0000269|PubMed:10986126, ECO:0000269|PubMed:15734645, ECO:0000269|PubMed:15780611, ECO:0000269|PubMed:17196980, ECO:0000269|PubMed:17623656, ECO:0000269|PubMed:19422229, ECO:0000269|PubMed:20005097, ECO:0000269|PubMed:20726512, ECO:0000269|PubMed:22689580, ECO:0000269|PubMed:23810497, ECO:0000269|PubMed:23913860, ECO:0000269|PubMed:8969305
source Swiss-Prot : SWS_FT_FI2

56) chain C
residue 202
type BINDING
sequence D
description BINDING => ECO:0000269|PubMed:10926524, ECO:0000269|PubMed:10986126, ECO:0000269|PubMed:15734645, ECO:0000269|PubMed:15780611, ECO:0000269|PubMed:17196980, ECO:0000269|PubMed:17623656, ECO:0000269|PubMed:19422229, ECO:0000269|PubMed:20005097, ECO:0000269|PubMed:20726512, ECO:0000269|PubMed:22689580, ECO:0000269|PubMed:23810497, ECO:0000269|PubMed:23913860, ECO:0000269|PubMed:8969305
source Swiss-Prot : SWS_FT_FI2

57) chain C
residue 203
type BINDING
sequence D
description BINDING => ECO:0000269|PubMed:10926524, ECO:0000269|PubMed:10986126, ECO:0000269|PubMed:15734645, ECO:0000269|PubMed:15780611, ECO:0000269|PubMed:17196980, ECO:0000269|PubMed:17623656, ECO:0000269|PubMed:19422229, ECO:0000269|PubMed:20005097, ECO:0000269|PubMed:20726512, ECO:0000269|PubMed:22689580, ECO:0000269|PubMed:23810497, ECO:0000269|PubMed:23913860, ECO:0000269|PubMed:8969305
source Swiss-Prot : SWS_FT_FI2

58) chain C
residue 205
type BINDING
sequence E
description BINDING => ECO:0000269|PubMed:10926524, ECO:0000269|PubMed:10986126, ECO:0000269|PubMed:15734645, ECO:0000269|PubMed:15780611, ECO:0000269|PubMed:17196980, ECO:0000269|PubMed:17623656, ECO:0000269|PubMed:19422229, ECO:0000269|PubMed:20005097, ECO:0000269|PubMed:20726512, ECO:0000269|PubMed:22689580, ECO:0000269|PubMed:23810497, ECO:0000269|PubMed:23913860, ECO:0000269|PubMed:8969305
source Swiss-Prot : SWS_FT_FI2

59) chain C
residue 172
type BINDING
sequence H
description BINDING => ECO:0000269|PubMed:10926524, ECO:0000269|PubMed:10986126, ECO:0000269|PubMed:15734645, ECO:0000269|PubMed:15780611, ECO:0000269|PubMed:17196980, ECO:0000269|PubMed:17623656, ECO:0000269|PubMed:19422229, ECO:0000269|PubMed:20005097, ECO:0000269|PubMed:20726512, ECO:0000269|PubMed:22689580, ECO:0000269|PubMed:23810497, ECO:0000269|PubMed:23913860
source Swiss-Prot : SWS_FT_FI3

60) chain C
residue 174
type BINDING
sequence D
description BINDING => ECO:0000269|PubMed:10926524, ECO:0000269|PubMed:10986126, ECO:0000269|PubMed:15734645, ECO:0000269|PubMed:15780611, ECO:0000269|PubMed:17196980, ECO:0000269|PubMed:17623656, ECO:0000269|PubMed:19422229, ECO:0000269|PubMed:20005097, ECO:0000269|PubMed:20726512, ECO:0000269|PubMed:22689580, ECO:0000269|PubMed:23810497, ECO:0000269|PubMed:23913860
source Swiss-Prot : SWS_FT_FI3

61) chain C
residue 187
type BINDING
sequence H
description BINDING => ECO:0000269|PubMed:10926524, ECO:0000269|PubMed:10986126, ECO:0000269|PubMed:15734645, ECO:0000269|PubMed:15780611, ECO:0000269|PubMed:17196980, ECO:0000269|PubMed:17623656, ECO:0000269|PubMed:19422229, ECO:0000269|PubMed:20005097, ECO:0000269|PubMed:20726512, ECO:0000269|PubMed:22689580, ECO:0000269|PubMed:23810497, ECO:0000269|PubMed:23913860
source Swiss-Prot : SWS_FT_FI3

62) chain C
residue 200
type BINDING
sequence H
description BINDING => ECO:0000269|PubMed:10926524, ECO:0000269|PubMed:10986126, ECO:0000269|PubMed:15734645, ECO:0000269|PubMed:15780611, ECO:0000269|PubMed:17196980, ECO:0000269|PubMed:17623656, ECO:0000269|PubMed:19422229, ECO:0000269|PubMed:20005097, ECO:0000269|PubMed:20726512, ECO:0000269|PubMed:22689580, ECO:0000269|PubMed:23810497, ECO:0000269|PubMed:23913860
source Swiss-Prot : SWS_FT_FI3

63) chain C
residue 222
type BINDING
sequence H
description BINDING => ECO:0000269|PubMed:10926524, ECO:0000269|PubMed:10986126, ECO:0000269|PubMed:15734645, ECO:0000269|PubMed:15780611, ECO:0000269|PubMed:17196980, ECO:0000269|PubMed:17623656, ECO:0000269|PubMed:19422229, ECO:0000269|PubMed:20005097, ECO:0000269|PubMed:20726512, ECO:0000269|PubMed:22689580, ECO:0000269|PubMed:23810497, ECO:0000269|PubMed:23913860
source Swiss-Prot : SWS_FT_FI3

64) chain C
residue 226
type BINDING
sequence H
description BINDING => ECO:0000269|PubMed:10926524, ECO:0000269|PubMed:10986126, ECO:0000269|PubMed:15734645, ECO:0000269|PubMed:15780611, ECO:0000269|PubMed:17196980, ECO:0000269|PubMed:17623656, ECO:0000269|PubMed:19422229, ECO:0000269|PubMed:20005097, ECO:0000269|PubMed:20726512, ECO:0000269|PubMed:22689580, ECO:0000269|PubMed:23810497, ECO:0000269|PubMed:23913860
source Swiss-Prot : SWS_FT_FI3

65) chain C
residue 232
type BINDING
sequence H
description BINDING => ECO:0000269|PubMed:10926524, ECO:0000269|PubMed:10986126, ECO:0000269|PubMed:15734645, ECO:0000269|PubMed:15780611, ECO:0000269|PubMed:17196980, ECO:0000269|PubMed:17623656, ECO:0000269|PubMed:19422229, ECO:0000269|PubMed:20005097, ECO:0000269|PubMed:20726512, ECO:0000269|PubMed:22689580, ECO:0000269|PubMed:23810497, ECO:0000269|PubMed:23913860
source Swiss-Prot : SWS_FT_FI3

66) chain C
residue 240
type BINDING
sequence M
description BINDING => ECO:0000269|PubMed:10926524, ECO:0000269|PubMed:10986126, ECO:0000269|PubMed:15734645, ECO:0000269|PubMed:15780611, ECO:0000269|PubMed:17196980, ECO:0000269|PubMed:17623656, ECO:0000269|PubMed:19422229, ECO:0000269|PubMed:20005097, ECO:0000269|PubMed:20726512, ECO:0000269|PubMed:22689580, ECO:0000269|PubMed:23810497, ECO:0000269|PubMed:23913860
source Swiss-Prot : SWS_FT_FI3

67) chain C
residue 117
type CARBOHYD
sequence N
description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:8576151
source Swiss-Prot : SWS_FT_FI4

68) chain C
residue 152
type CARBOHYD
sequence N
description N-linked (GlcNAc...) asparagine => ECO:0000255
source Swiss-Prot : SWS_FT_FI5


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