eF-site ID 3ljt-A
PDB Code 3ljt
Chain A

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Title Crystal Structure of the Catalytic Domain of ADAMTS-5 in Complex with an Amino-2-indanol compound
Classification HYDROLASE
Compound A disintegrin and metalloproteinase with thrombospondin motifs 5
Source Homo sapiens (Human) (ATS5_HUMAN)
Sequence A:  ASRARQVELLLVADASMARKYGRGLQHYLLTLASIANRLY
SHASIENHIRLAVVKVVVLGDKDKSLEVSKNAATTLKNFC
KWQHQHNQLGDDHEEHYDAAILFTREDLCGHHSCDTLGMA
DVGTICSPERSCAVIEDDGLHAAFTVAHEIGHLLGLSHDD
SKFCEETFGSTEDKRLMSSILTSIDASKPWSKCTSATITE
FLDDGHGNCLLDLPRKQI
Description


Functional site

1) chain A
residue 377
type
sequence D
description BINDING SITE FOR RESIDUE LA3 A 801
source : AC1

2) chain A
residue 378
type
sequence T
description BINDING SITE FOR RESIDUE LA3 A 801
source : AC1

3) chain A
residue 379
type
sequence L
description BINDING SITE FOR RESIDUE LA3 A 801
source : AC1

4) chain A
residue 380
type
sequence G
description BINDING SITE FOR RESIDUE LA3 A 801
source : AC1

5) chain A
residue 406
type
sequence F
description BINDING SITE FOR RESIDUE LA3 A 801
source : AC1

6) chain A
residue 407
type
sequence T
description BINDING SITE FOR RESIDUE LA3 A 801
source : AC1

7) chain A
residue 410
type
sequence H
description BINDING SITE FOR RESIDUE LA3 A 801
source : AC1

8) chain A
residue 411
type
sequence E
description BINDING SITE FOR RESIDUE LA3 A 801
source : AC1

9) chain A
residue 414
type
sequence H
description BINDING SITE FOR RESIDUE LA3 A 801
source : AC1

10) chain A
residue 420
type
sequence H
description BINDING SITE FOR RESIDUE LA3 A 801
source : AC1

11) chain A
residue 438
type
sequence L
description BINDING SITE FOR RESIDUE LA3 A 801
source : AC1

12) chain A
residue 440
type
sequence S
description BINDING SITE FOR RESIDUE LA3 A 801
source : AC1

13) chain A
residue 441
type
sequence S
description BINDING SITE FOR RESIDUE LA3 A 801
source : AC1

14) chain A
residue 443
type
sequence L
description BINDING SITE FOR RESIDUE LA3 A 801
source : AC1

15) chain A
residue 446
type
sequence I
description BINDING SITE FOR RESIDUE LA3 A 801
source : AC1

16) chain A
residue 372
type
sequence G
description BINDING SITE FOR RESIDUE EDO A 802
source : AC2

17) chain A
residue 385
type
sequence G
description BINDING SITE FOR RESIDUE EDO A 802
source : AC2

18) chain A
residue 386
type
sequence T
description BINDING SITE FOR RESIDUE EDO A 802
source : AC2

19) chain A
residue 389
type
sequence S
description BINDING SITE FOR RESIDUE EDO A 802
source : AC2

20) chain A
residue 468
type
sequence H
description BINDING SITE FOR RESIDUE EDO A 802
source : AC2

21) chain A
residue 410
type
sequence H
description BINDING SITE FOR RESIDUE ZN A 901
source : AC3

22) chain A
residue 414
type
sequence H
description BINDING SITE FOR RESIDUE ZN A 901
source : AC3

23) chain A
residue 420
type
sequence H
description BINDING SITE FOR RESIDUE ZN A 901
source : AC3

24) chain A
residue 270
type
sequence E
description BINDING SITE FOR RESIDUE CA A 902
source : AC4

25) chain A
residue 360
type
sequence D
description BINDING SITE FOR RESIDUE CA A 902
source : AC4

26) chain A
residue 471
type
sequence C
description BINDING SITE FOR RESIDUE CA A 902
source : AC4

27) chain A
residue 474
type
sequence D
description BINDING SITE FOR RESIDUE CA A 902
source : AC4

28) chain A
residue 270
type
sequence E
description BINDING SITE FOR RESIDUE CA A 903
source : AC5

29) chain A
residue 474
type
sequence D
description BINDING SITE FOR RESIDUE CA A 903
source : AC5

30) chain A
residue 475
type
sequence L
description BINDING SITE FOR RESIDUE CA A 903
source : AC5

31) chain A
residue 369
type
sequence D
description BINDING SITE FOR RESIDUE CA A 904
source : AC6

32) chain A
residue 370
type
sequence L
description BINDING SITE FOR RESIDUE CA A 904
source : AC6

33) chain A
residue 376
type
sequence C
description BINDING SITE FOR RESIDUE CA A 904
source : AC6

34) chain A
residue 378
type
sequence T
description BINDING SITE FOR RESIDUE CA A 904
source : AC6

35) chain A
residue 398
type
sequence E
description BINDING SITE FOR RESIDUE CA A 904
source : AC6

36) chain A
residue 407-416
type prosite
sequence TVAHEIGHLL
description ZINC_PROTEASE Neutral zinc metallopeptidases, zinc-binding region signature. TVAHEIGHLL
source prosite : PS00142

37) chain A
residue 411
type ACT_SITE
sequence E
description ACT_SITE => ECO:0000255|PROSITE-ProRule:PRU00276, ECO:0000255|PROSITE-ProRule:PRU10095, ECO:0000269|PubMed:18042673
source Swiss-Prot : SWS_FT_FI1

38) chain A
residue 410
type BINDING
sequence H
description BINDING => ECO:0000269|PubMed:18042673
source Swiss-Prot : SWS_FT_FI2

39) chain A
residue 414
type BINDING
sequence H
description BINDING => ECO:0000269|PubMed:18042673
source Swiss-Prot : SWS_FT_FI2

40) chain A
residue 420
type BINDING
sequence H
description BINDING => ECO:0000269|PubMed:18042673
source Swiss-Prot : SWS_FT_FI2


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