eF-site ID 3lj3-A PDB Code 3lj3 Chain A click to enlarge Title PI3-kinase-gamma with a pyrrolopyridine-benzofuran inhibitor Classification TRANSFERASE Compound Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform Source Homo sapiens (Human) (PK3CG_HUMAN) Sequence A:  MSEESQAFQRQLTALIGYDVTDVSNVHDDELEFTRRGLVT PRMAEVASRDPKLYAMHPWVTSKPLPEYLWKKIANNCIFI VIHRSTTSQTIKVSPDDTPGAILQSFFTKMSEQDFVLRVC GRDEYLVGETPIKNFQWVRHCLKNGEEIHVVLDTPPDPAL DEVRKEWDCDRKFRVKIRGIDIPVLDLTVFVEANIQHGQQ VLCQRRTSPKPFTEEVLWNVWLEFSIKIKDLPKGALLNLQ IYCVRLLYYVNLLLIDHRFLLRRGEYVLHMWQISSFNADK LTSATNPDKENSMSISILLDNAEMPNQLRKQLEAIIATDP LNPLTAEDKELLWHFRYESLKHPKAYPKLFSSVKWGQQEI VAKTYQLLARREVWDQSALDVGLTMQLLDCNFSDENVRAI AVQKLESLEDDDVLHYLLQLVQAVKFEPYHDSALARFLLK RGLRNKRIGHFLFWFLRSEIAQSRHYQQRFAVILEAYLRG CGTAMLHDFTQQVQVIEMLQKVTLDIKSLVSSQVISQLKQ KLENLQNSQLPESFRVPYDPGLKAGALAIEKCKVMASKKK PLWLEFKCADPTALSNETIGIIFKHGDDLRQDMLILQILR IMESIWETESLDLCLLPYGCISTGDKIGMIEIVKDATTIA KIQQSVGNTGAFKDEVLNHWLKEKSPTEEKFQAAVERFVY SCAGYCVATFVLGIGDRHNDNIMITETGNLFHIDFGHILE RVPFVLTPDFLFVMGTSGKKTSPHFQKFQDICVKAYLALR HHTNLLIILFSMMLMTGMPQLTSKEDIEYIRDALTVGKNE EDAKKYFLDQIEVCRDKGWTVQFNWFLHL Description Functional site 1) chain A residue 206 type sequence P description BINDING SITE FOR RESIDUE SO4 A 1 source : AC1 2) chain A residue 207 type sequence L description BINDING SITE FOR RESIDUE SO4 A 1 source : AC1 3) chain A residue 212 type sequence W description BINDING SITE FOR RESIDUE SO4 A 1 source : AC1 4) chain A residue 288 type sequence K description BINDING SITE FOR RESIDUE SO4 A 1 source : AC1 5) chain A residue 546 type sequence E description BINDING SITE FOR RESIDUE SO4 A 2 source : AC2 6) chain A residue 576 type sequence W description BINDING SITE FOR RESIDUE SO4 A 2 source : AC2 7) chain A residue 579 type sequence R description BINDING SITE FOR RESIDUE SO4 A 2 source : AC2 8) chain A residue 606 type sequence K description BINDING SITE FOR RESIDUE SO4 A 2 source : AC2 9) chain A residue 804 type sequence M description BINDING SITE FOR RESIDUE WYE A 1109 source : AC3 10) chain A residue 812 type sequence W description BINDING SITE FOR RESIDUE WYE A 1109 source : AC3 11) chain A residue 831 type sequence I description BINDING SITE FOR RESIDUE WYE A 1109 source : AC3 12) chain A residue 833 type sequence K description BINDING SITE FOR RESIDUE WYE A 1109 source : AC3 13) chain A residue 841 type sequence D description BINDING SITE FOR RESIDUE WYE A 1109 source : AC3 14) chain A residue 867 type sequence Y description BINDING SITE FOR RESIDUE WYE A 1109 source : AC3 15) chain A residue 879 type sequence I description BINDING SITE FOR RESIDUE WYE A 1109 source : AC3 16) chain A residue 880 type sequence E description BINDING SITE FOR RESIDUE WYE A 1109 source : AC3 17) chain A residue 882 type sequence V description BINDING SITE FOR RESIDUE WYE A 1109 source : AC3 18) chain A residue 953 type sequence M description BINDING SITE FOR RESIDUE WYE A 1109 source : AC3 19) chain A residue 964 type sequence D description BINDING SITE FOR RESIDUE WYE A 1109 source : AC3 20) chain A residue 832-846 type prosite sequence FKHGDDLRQDMLILQ description PI3_4_KINASE_1 Phosphatidylinositol 3- and 4-kinases signature 1. FKhg.DDLRQDmlilQ source prosite : PS00915 21) chain A residue 931-951 type prosite sequence SCAGYCVATFVLGIGDRHNDN description PI3_4_KINASE_2 Phosphatidylinositol 3- and 4-kinases signature 2. ScAgycVatFVLgIgDRHndN source prosite : PS00916 22) chain A residue 829 type BINDING sequence G description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI1 23) chain A residue 864 type BINDING sequence L description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI1 24) chain A residue 961 type BINDING sequence F description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI1 25) chain A residue 1024 type MOD_RES sequence T description Phosphothreonine; by PKA => ECO:0000250|UniProtKB:Q9JHG7 source Swiss-Prot : SWS_FT_FI2

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