|
|
eF-site ID
|
3lhm-A |
|
PDB Code
|
3lhm |
|
Chain
|
A |
|
click to enlarge
|
|
|
Title
|
CRYSTAL STRUCTURES OF THE APO-AND HOLOMUTANT HUMAN LYSOZYMES WITH AN INTRODUCED CA2+ BINDING SITE |
|
Classification
|
HYDROLASE (O-GLYCOSYL) |
|
Compound
|
HUMAN LYSOZYME |
|
Source
|
Homo sapiens (Human) (LYSC_HUMAN) |
|
|
Sequence
|
A: |
KVFERCELARTLKRLGMDGYRGISLANWMCLAKWESGYNT
RATNYNAGDRSTDYGIFQINSRYWCNDGKTPGAVNACHLS
CSALLDDNIADDVACAKRVVRDPQGIRAWVAWRNRCQNRD
VRQYVQGCGV
|
|
|
Description
|
(1) |
LYSOZYME (E.C.3.2.1.17) (HOLO) (MUTANT WITH GLN 86 REPLACED BY ASP AND ALA 92 REPLACED BY ASP) (Q86D,A92D)
|
|
Functional site
|
|
|
1)
|
chain |
A |
| residue |
83 |
| type |
|
| sequence |
A
|
| description |
BINDING SITE FOR RESIDUE CA A 131
|
| source |
: AC1
|
|
|
2)
|
chain |
A |
| residue |
86 |
| type |
|
| sequence |
D
|
| description |
BINDING SITE FOR RESIDUE CA A 131
|
| source |
: AC1
|
|
|
3)
|
chain |
A |
| residue |
88 |
| type |
|
| sequence |
N
|
| description |
BINDING SITE FOR RESIDUE CA A 131
|
| source |
: AC1
|
|
|
4)
|
chain |
A |
| residue |
91 |
| type |
|
| sequence |
D
|
| description |
BINDING SITE FOR RESIDUE CA A 131
|
| source |
: AC1
|
|
|
5)
|
chain |
A |
| residue |
92 |
| type |
|
| sequence |
D
|
| description |
BINDING SITE FOR RESIDUE CA A 131
|
| source |
: AC1
|
|
|
6)
|
chain |
A |
| residue |
77-95 |
| type |
prosite |
| sequence |
CHLSCSALLDDNIADDVAC
|
| description |
GLYCOSYL_HYDROL_F22_1 Glycosyl hydrolases family 22 (GH22) domain signature. ChlsCsaLlddNIaddvaC
|
| source |
prosite : PS00128
|
|
|
7)
|
chain |
A |
| residue |
35 |
| type |
ACT_SITE |
| sequence |
E
|
| description |
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
|
8)
|
chain |
A |
| residue |
53 |
| type |
ACT_SITE |
| sequence |
D
|
| description |
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
|
|