eF-site ID 3lck-A PDB Code 3lck Chain A click to enlarge Title THE KINASE DOMAIN OF HUMAN LYMPHOCYTE KINASE (LCK), ACTIVATED FORM (AUTO-PHOSPHORYLATED ON TYR394) Classification TYROSINE-PROTEIN KINASE Compound PROTO-ONCOGENE TYROSINE-PROTEIN KINASE Source Homo sapiens (Human) (LCK_HUMAN) Sequence A:  KPWWEDEWEVPRETLKLVERLGAGQFGEVWMGYYNGHTKV AVKSLKQGSMSPDAFLAEANLMKQLQHQRLVRLYAVVTQE PIYIITEYMENGSLVDFLKTPSGIKLTINKLLDMAAQIAE GMAFIEERNYIHRDLRAANILVSDTLSCKIADFGLARLIE DNEXTAREGAKFPIKWTAPEAINYGTFTIKSDVWSFGILL TEIVTHGRIPYPGMTNPEVIQNLERGYRMVRPDNCPEELY QLMRLCWKERPEDRPTFDYLRSVLEDFFTAT Description Functional site 1) chain A residue 298 type sequence Q description BINDING SITE FOR RESIDUE SO4 A 901 source : AC1 2) chain A residue 299 type sequence R description BINDING SITE FOR RESIDUE SO4 A 901 source : AC1 3) chain A residue 377 type sequence S description BINDING SITE FOR RESIDUE SO4 A 901 source : AC1 4) chain A residue 379 type sequence K description BINDING SITE FOR RESIDUE SO4 A 901 source : AC1 5) chain A residue 457 type sequence Y description BINDING SITE FOR RESIDUE SO4 A 901 source : AC1 6) chain A residue 458 type sequence R description BINDING SITE FOR RESIDUE SO4 A 901 source : AC1 7) chain A residue 474 type sequence R description BINDING SITE FOR RESIDUE SO4 A 901 source : AC1 8) chain A residue 365 type ACT_SITE sequence L description Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10028 source Swiss-Prot : SWS_FT_FI1 9) chain A residue 252 type BINDING sequence G description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159 source Swiss-Prot : SWS_FT_FI2 10) chain A residue 274 type BINDING sequence S description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159 source Swiss-Prot : SWS_FT_FI2 11) chain A residue 395 type MOD_RES sequence T description Phosphotyrosine; by autocatalysis => ECO:0000269|PubMed:8139546 source Swiss-Prot : SWS_FT_FI3 12) chain A residue 251-273 type prosite sequence LGAGQFGEVWMGYYNGHTKVAVK description PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGAGQFGEVWmGyynghtk...........VAVK source prosite : PS00107 13) chain A residue 360-372 type prosite sequence YIHRDLRAANILV description PROTEIN_KINASE_TYR Tyrosine protein kinases specific active-site signature. YIHrDLRAANILV source prosite : PS00109

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