|
|
eF-site ID
|
3lcb-D |
|
PDB Code
|
3lcb |
|
Chain
|
D |
|
click to enlarge
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Title
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The crystal structure of isocitrate dehydrogenase kinase/phosphatase in complex with its substrate, isocitrate dehydrogenase, from Escherichia coli. |
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Classification
|
TRANSFERASE, HYDROLASE |
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Compound
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Isocitrate dehydrogenase kinase/phosphatase |
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Source
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null (IDH_ECOLI) |
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Sequence
|
D: |
ESKVVVPAQGKKITLQNGKLNVPENPIIPYIEGDGIGVDV
TPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQD
VWLPAETLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQE
LDLYICLRPVRYYQGTPSPVKHPELTDMVIFRENSEDIYA
GIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPC
SEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAF
KDWGYQLAREEFGGELIDGGPWLKVKNPNTGKEIVIKDVI
ADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGIG
IAPGANIGDECALFEATHGTAPKYAGQDKVNPGSIILSAE
MMLRHMGWTEAADLIVKGMEGAINAKTVTYDFERLMDGAK
LLKCSEFGDAIIENM
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Description
|
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Functional site
|
|
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1)
|
chain |
D |
| residue |
395 |
| type |
BINDING |
| sequence |
R
|
| description |
BINDING => ECO:0000269|PubMed:11284679, ECO:0000269|PubMed:2682654, ECO:0000269|PubMed:7761851, ECO:0007744|PDB:1AI2, ECO:0007744|PDB:9ICD
|
| source |
Swiss-Prot : SWS_FT_FI7
|
|
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2)
|
chain |
D |
| residue |
160 |
| type |
SITE |
| sequence |
Y
|
| description |
Critical for catalysis => ECO:0000269|PubMed:7761851, ECO:0000269|PubMed:7819221
|
| source |
Swiss-Prot : SWS_FT_FI8
|
|
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3)
|
chain |
D |
| residue |
230 |
| type |
SITE |
| sequence |
K
|
| description |
Critical for catalysis => ECO:0000269|PubMed:7761851, ECO:0000269|PubMed:7819221
|
| source |
Swiss-Prot : SWS_FT_FI8
|
|
|
4)
|
chain |
D |
| residue |
100 |
| type |
MOD_RES |
| sequence |
K
|
| description |
N6-succinyllysine => ECO:0000269|PubMed:21151122
|
| source |
Swiss-Prot : SWS_FT_FI9
|
|
|
5)
|
chain |
D |
| residue |
242 |
| type |
MOD_RES |
| sequence |
K
|
| description |
N6-succinyllysine => ECO:0000269|PubMed:21151122
|
| source |
Swiss-Prot : SWS_FT_FI9
|
|
|
6)
|
chain |
D |
| residue |
113 |
| type |
MOD_RES |
| sequence |
S
|
| description |
Phosphoserine => ECO:0000269|PubMed:2204109, ECO:0000269|PubMed:3112144
|
| source |
Swiss-Prot : SWS_FT_FI10
|
|
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7)
|
chain |
D |
| residue |
142 |
| type |
MOD_RES |
| sequence |
K
|
| description |
N6-acetyllysine => ECO:0000269|PubMed:18723842
|
| source |
Swiss-Prot : SWS_FT_FI11
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|
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8)
|
chain |
D |
| residue |
104 |
| type |
BINDING |
| sequence |
T
|
| description |
BINDING => ECO:0000269|PubMed:11284679, ECO:0000269|PubMed:2682654, ECO:0000269|PubMed:7761851, ECO:0007744|PDB:1AI2, ECO:0007744|PDB:1HJ6, ECO:0007744|PDB:1IDE, ECO:0007744|PDB:4AJ3, ECO:0007744|PDB:4AJR
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
|
9)
|
chain |
D |
| residue |
119 |
| type |
BINDING |
| sequence |
R
|
| description |
BINDING => ECO:0000269|PubMed:10623532, ECO:0000269|PubMed:2204109, ECO:0007744|PDB:1AI3, ECO:0007744|PDB:1CW7, ECO:0007744|PDB:1GRP, ECO:0007744|PDB:1P8F, ECO:0007744|PDB:1PB1, ECO:0007744|PDB:4AJ3, ECO:0007744|PDB:4AJA, ECO:0007744|PDB:4AJB, ECO:0007744|PDB:4AJS, ECO:0007744|PDB:4BNP, ECO:0007744|PDB:5ICD, ECO:0007744|PDB:8ICD
|
| source |
Swiss-Prot : SWS_FT_FI3
|
|
|
10)
|
chain |
D |
| residue |
307 |
| type |
BINDING |
| sequence |
D
|
| description |
BINDING => ECO:0000269|PubMed:11284679, ECO:0000269|PubMed:2204109, ECO:0000269|PubMed:7761851, ECO:0007744|PDB:1AI3, ECO:0007744|PDB:1BL5, ECO:0007744|PDB:1GRP, ECO:0007744|PDB:1HJ6, ECO:0007744|PDB:1IDC, ECO:0007744|PDB:1P8F, ECO:0007744|PDB:4AJB, ECO:0007744|PDB:4AJR, ECO:0007744|PDB:4AJS, ECO:0007744|PDB:4BNP, ECO:0007744|PDB:8ICD
|
| source |
Swiss-Prot : SWS_FT_FI4
|
|
|
11)
|
chain |
D |
| residue |
339 |
| type |
BINDING |
| sequence |
H
|
| description |
BINDING => ECO:0000269|PubMed:11284679, ECO:0000269|PubMed:2682654, ECO:0000269|PubMed:7761851, ECO:0007744|PDB:1AI2, ECO:0007744|PDB:1BL5, ECO:0007744|PDB:1HJ6, ECO:0007744|PDB:1IDE, ECO:0007744|PDB:1ISO, ECO:0007744|PDB:4AJ3, ECO:0007744|PDB:4AJR, ECO:0007744|PDB:9ICD
|
| source |
Swiss-Prot : SWS_FT_FI5
|
|
|
12)
|
chain |
D |
| residue |
352 |
| type |
BINDING |
| sequence |
N
|
| description |
BINDING => ECO:0000269|PubMed:11284679, ECO:0000269|PubMed:2682654, ECO:0000269|PubMed:7761851, ECO:0007744|PDB:1AI2, ECO:0007744|PDB:1BL5, ECO:0007744|PDB:1HJ6, ECO:0007744|PDB:1IDE, ECO:0007744|PDB:4AJ3, ECO:0007744|PDB:4AJR, ECO:0007744|PDB:9ICD
|
| source |
Swiss-Prot : SWS_FT_FI6
|
|
|
13)
|
chain |
D |
| residue |
391 |
| type |
BINDING |
| sequence |
Y
|
| description |
BINDING => ECO:0000269|PubMed:11284679, ECO:0000269|PubMed:2682654, ECO:0000269|PubMed:7761851, ECO:0007744|PDB:1AI2, ECO:0007744|PDB:1BL5, ECO:0007744|PDB:1HJ6, ECO:0007744|PDB:1IDE, ECO:0007744|PDB:4AJ3, ECO:0007744|PDB:4AJR, ECO:0007744|PDB:9ICD
|
| source |
Swiss-Prot : SWS_FT_FI6
|
|
|
14)
|
chain |
D |
| residue |
160 |
| type |
catalytic |
| sequence |
Y
|
| description |
7
|
| source |
MCSA : MCSA2
|
|
|
15)
|
chain |
D |
| residue |
230 |
| type |
catalytic |
| sequence |
K
|
| description |
7
|
| source |
MCSA : MCSA2
|
|
|
16)
|
chain |
D |
| residue |
283 |
| type |
catalytic |
| sequence |
D
|
| description |
7
|
| source |
MCSA : MCSA2
|
|
|
17)
|
chain |
D |
| residue |
307 |
| type |
catalytic |
| sequence |
D
|
| description |
7
|
| source |
MCSA : MCSA2
|
|
|
18)
|
chain |
D |
| residue |
113 |
| type |
BINDING |
| sequence |
S
|
| description |
BINDING => ECO:0000269|PubMed:10623532, ECO:0000269|PubMed:2204109, ECO:0007744|PDB:1AI3, ECO:0007744|PDB:1CW1, ECO:0007744|PDB:1CW7, ECO:0007744|PDB:1GRP, ECO:0007744|PDB:1P8F, ECO:0007744|PDB:1PB1, ECO:0007744|PDB:4AJ3, ECO:0007744|PDB:4AJA, ECO:0007744|PDB:4AJB, ECO:0007744|PDB:4AJS, ECO:0007744|PDB:4BNP, ECO:0007744|PDB:5ICD, ECO:0007744|PDB:8ICD
|
| source |
Swiss-Prot : SWS_FT_FI2
|
|
|
19)
|
chain |
D |
| residue |
115 |
| type |
BINDING |
| sequence |
N
|
| description |
BINDING => ECO:0000269|PubMed:10623532, ECO:0000269|PubMed:2204109, ECO:0007744|PDB:1AI3, ECO:0007744|PDB:1CW1, ECO:0007744|PDB:1CW7, ECO:0007744|PDB:1GRP, ECO:0007744|PDB:1P8F, ECO:0007744|PDB:1PB1, ECO:0007744|PDB:4AJ3, ECO:0007744|PDB:4AJA, ECO:0007744|PDB:4AJB, ECO:0007744|PDB:4AJS, ECO:0007744|PDB:4BNP, ECO:0007744|PDB:5ICD, ECO:0007744|PDB:8ICD
|
| source |
Swiss-Prot : SWS_FT_FI2
|
|
|
20)
|
chain |
D |
| residue |
129 |
| type |
BINDING |
| sequence |
R
|
| description |
BINDING => ECO:0000269|PubMed:10623532, ECO:0000269|PubMed:2204109, ECO:0007744|PDB:1AI3, ECO:0007744|PDB:1CW1, ECO:0007744|PDB:1CW7, ECO:0007744|PDB:1GRP, ECO:0007744|PDB:1P8F, ECO:0007744|PDB:1PB1, ECO:0007744|PDB:4AJ3, ECO:0007744|PDB:4AJA, ECO:0007744|PDB:4AJB, ECO:0007744|PDB:4AJS, ECO:0007744|PDB:4BNP, ECO:0007744|PDB:5ICD, ECO:0007744|PDB:8ICD
|
| source |
Swiss-Prot : SWS_FT_FI2
|
|
|
21)
|
chain |
D |
| residue |
153 |
| type |
BINDING |
| sequence |
R
|
| description |
BINDING => ECO:0000269|PubMed:10623532, ECO:0000269|PubMed:2204109, ECO:0007744|PDB:1AI3, ECO:0007744|PDB:1CW1, ECO:0007744|PDB:1CW7, ECO:0007744|PDB:1GRP, ECO:0007744|PDB:1P8F, ECO:0007744|PDB:1PB1, ECO:0007744|PDB:4AJ3, ECO:0007744|PDB:4AJA, ECO:0007744|PDB:4AJB, ECO:0007744|PDB:4AJS, ECO:0007744|PDB:4BNP, ECO:0007744|PDB:5ICD, ECO:0007744|PDB:8ICD
|
| source |
Swiss-Prot : SWS_FT_FI2
|
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|
|