eF-site ID 3lc6-AB PDB Code 3lc6 Chain A, B click to enlarge Title The alternative conformation structure of isocitrate dehydrogenase kinase/phosphatase from E. Coli Classification TRANSFERASE, HYDROLASE Compound Isocitrate dehydrogenase kinase/phosphatase Source null (ACEK_ECO5E) Sequence A:  RGLELLIAQTILQGFDAQYGRFLEVTSGAQQRFEQADWHA VQQAMKNRIHLYDHHVGLVVEQLRCITNGQSTDAEFLLRV KEHYTRLLPDYPRFEIAESFFNSVYCRLFDHRSLTPERLF IFSSQPERRFRTIPRPLAKDFHPDHGWESLLMRVISDLPL RLHWQNKSRDIHYIIRHLTETLSKSHLQVANELFYRNKAA WLVGKLITPSGTLPFLLPIHQTDDGELFIDTCLTTTAEAS IVFGFARSYFMVYAPLPAALVEWLREILPGKTTAELYMAI GCQKHAKTESYREYLVYLQGCNEQFIEAPGIRGMVMLVFT LPGFDRVFKVIKDKFAPQKEMSAAHVRACYQLVKEHDRVG RMADTQEFENFVLEKRHISPALMELLLQEAAEKITDLGEQ IVIRHLYIERRMVPLNIWLEQVEGQQLRDAIEEYGNAIRQ LAAANIFPGDMLFKNFGVTRHGRVVFYDYDEICYMTEVNF RDIPSPGDVFPEEFRHWLCADPRIGPLFEEMHADLFRADY WRALQNRIREGHVEDVYAYRRRQRFSV B:  PRGLELLIAQTILQGFDAQYGRFLEVTSGAQQRFEQADWH AVQQAMKNRIHLYDHHVGLVVEQLRCITNGQSTDAEFLLR VKEHYTRLLPDYPRFEIAESFFNSVYCRLDHRSLTPERLF IFSSQPTIPRPLAKDFHPDHGWESLLMRVISDLPLRLHWQ NKSRDIHYIIRHLTETLGPENLSKSHLQVANELFYRNKAA WLVGKLITPSGTLPFLLPIHQTDDGELFIDTCLTTTAEAS IVFGFARSYFMVYAPLPAALVEWLREILPGKTTAELYMAI GCQKHAKTESYREYLVYLQGCNEQFIEAPGIRGMVMLVFT LPGFDRVFKVIKDKFAHVRACYQLVKEHDRVGRMADTQEF ENFVLEKRHISPALMELLLQEAAEKITDLGEQIVIRHLYI ERRMVPLNIWLEQVEGQQLRDAIEEYGNAIRQLAAANIFP GDMLFKNFGVTRHGRVVFYDYDEICYMTEVNFRDIGDVFP EEFRHWLCADPRIGPLFEEMHADLFRADYWRALQNRIREG HVEDVYAYRRRQRFSVRYG Description Functional site 1) chain A residue 316 type sequence P description BINDING SITE FOR RESIDUE ADP A 1762 source : AC1 2) chain A residue 318 type sequence I description BINDING SITE FOR RESIDUE ADP A 1762 source : AC1 3) chain A residue 320 type sequence G description BINDING SITE FOR RESIDUE ADP A 1762 source : AC1 4) chain A residue 321 type sequence M description BINDING SITE FOR RESIDUE ADP A 1762 source : AC1 5) chain A residue 322 type sequence V description BINDING SITE FOR RESIDUE ADP A 1762 source : AC1 6) chain A residue 323 type sequence M description BINDING SITE FOR RESIDUE ADP A 1762 source : AC1 7) chain A residue 325 type sequence V description BINDING SITE FOR RESIDUE ADP A 1762 source : AC1 8) chain A residue 334 type sequence V description BINDING SITE FOR RESIDUE ADP A 1762 source : AC1 9) chain A residue 336 type sequence K description BINDING SITE FOR RESIDUE ADP A 1762 source : AC1 10) chain A residue 416 type sequence E description BINDING SITE FOR RESIDUE ADP A 1762 source : AC1 11) chain A residue 417 type sequence R description BINDING SITE FOR RESIDUE ADP A 1762 source : AC1 12) chain A residue 419 type sequence M description BINDING SITE FOR RESIDUE ADP A 1762 source : AC1 13) chain A residue 421 type sequence P description BINDING SITE FOR RESIDUE ADP A 1762 source : AC1 14) chain A residue 462 type sequence N description BINDING SITE FOR RESIDUE ADP A 1762 source : AC1 15) chain A residue 474 type sequence Y description BINDING SITE FOR RESIDUE ADP A 1762 source : AC1 16) chain A residue 475 type sequence D description BINDING SITE FOR RESIDUE ADP A 1762 source : AC1 17) chain A residue 461 type sequence K description BINDING SITE FOR RESIDUE MG A 579 source : AC2 18) chain A residue 462 type sequence N description BINDING SITE FOR RESIDUE MG A 579 source : AC2 19) chain A residue 475 type sequence D description BINDING SITE FOR RESIDUE MG A 579 source : AC2 20) chain B residue 101 type sequence S description BINDING SITE FOR RESIDUE AMP B 1604 source : AC3 21) chain B residue 104 type sequence N description BINDING SITE FOR RESIDUE AMP B 1604 source : AC3 22) chain B residue 105 type sequence S description BINDING SITE FOR RESIDUE AMP B 1604 source : AC3 23) chain B residue 113 type sequence H description BINDING SITE FOR RESIDUE AMP B 1604 source : AC3 24) chain B residue 123 type sequence I description BINDING SITE FOR RESIDUE AMP B 1604 source : AC3 25) chain B residue 291 type sequence K description BINDING SITE FOR RESIDUE AMP B 1604 source : AC3 26) chain B residue 294 type sequence K description BINDING SITE FOR RESIDUE AMP B 1604 source : AC3 27) chain B residue 295 type sequence T description BINDING SITE FOR RESIDUE AMP B 1604 source : AC3 28) chain B residue 375 type sequence F description BINDING SITE FOR RESIDUE AMP B 1604 source : AC3 29) chain B residue 377 type sequence N description BINDING SITE FOR RESIDUE AMP B 1604 source : AC3 30) chain A residue 371 type ACT_SITE sequence D description ACT_SITE => ECO:0000255|HAMAP-Rule:MF_00747 source Swiss-Prot : SWS_FT_FI1 31) chain B residue 371 type ACT_SITE sequence D description ACT_SITE => ECO:0000255|HAMAP-Rule:MF_00747 source Swiss-Prot : SWS_FT_FI1 32) chain A residue 370 type ACT_SITE sequence A description ACT_SITE => ECO:0000255|HAMAP-Rule:MF_00747 source Swiss-Prot : SWS_FT_FI1 33) chain B residue 370 type ACT_SITE sequence A description ACT_SITE => ECO:0000255|HAMAP-Rule:MF_00747 source Swiss-Prot : SWS_FT_FI1 34) chain B residue 314 type BINDING sequence E description BINDING => ECO:0000255|HAMAP-Rule:MF_00747 source Swiss-Prot : SWS_FT_FI2 35) chain B residue 335 type BINDING sequence F description BINDING => ECO:0000255|HAMAP-Rule:MF_00747 source Swiss-Prot : SWS_FT_FI2 36) chain A residue 315 type BINDING sequence A description BINDING => ECO:0000255|HAMAP-Rule:MF_00747 source Swiss-Prot : SWS_FT_FI2 37) chain A residue 336 type BINDING sequence K description BINDING => ECO:0000255|HAMAP-Rule:MF_00747 source Swiss-Prot : SWS_FT_FI2 38) chain B residue 315 type BINDING sequence A description BINDING => ECO:0000255|HAMAP-Rule:MF_00747 source Swiss-Prot : SWS_FT_FI2 39) chain B residue 336 type BINDING sequence K description BINDING => ECO:0000255|HAMAP-Rule:MF_00747 source Swiss-Prot : SWS_FT_FI2 40) chain A residue 314 type BINDING sequence E description BINDING => ECO:0000255|HAMAP-Rule:MF_00747 source Swiss-Prot : SWS_FT_FI2 41) chain A residue 335 type BINDING sequence F description BINDING => ECO:0000255|HAMAP-Rule:MF_00747 source Swiss-Prot : SWS_FT_FI2

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