eF-site ID 3l3m-A PDB Code 3l3m Chain A click to enlarge Title PARP complexed with A927929 Classification TRANSFERASE Compound Poly [ADP-ribose] polymerase 1 Source Homo sapiens (Human) (PARP1_HUMAN) Sequence A:  SKLPKPVQDLIKMIFDVESMKKAMVEYEIDLQKMPLGKLS KRQIQAAYSILSEVQQAVSQGSSDSQILDLSNRFYTLIPH DFGMKKPPLLNNADSVQAKAEMLDNLLDIEVAYSLLRGGS DDSSKDPIDVNYEKLKTDIKVVDRDSEEAEIIRKYVKNTH ATTHNAYDLEVIDIFKIEREGECQRYKPFKQLHNRRLLWH GSRTTNFAGILSQGLRIAPPEAPVTGYMFGKGIYFADMVS KSANYCHTSQGDPIGLILLGEVALGNMYELKHASHISKLP KGKHSVKGLGKTTPDPSANISLDGVDVPLGTGISSGVNDT SLLYNEYIVYDIAQVNLKYLLKLKFNFK Description Functional site 1) chain A residue 98 type sequence Q description BINDING SITE FOR RESIDUE A92 A 351 source : AC1 2) chain A residue 102 type sequence E description BINDING SITE FOR RESIDUE A92 A 351 source : AC1 3) chain A residue 105 type sequence D description BINDING SITE FOR RESIDUE A92 A 351 source : AC1 4) chain A residue 201 type sequence H description BINDING SITE FOR RESIDUE A92 A 351 source : AC1 5) chain A residue 202 type sequence G description BINDING SITE FOR RESIDUE A92 A 351 source : AC1 6) chain A residue 227 type sequence G description BINDING SITE FOR RESIDUE A92 A 351 source : AC1 7) chain A residue 228 type sequence Y description BINDING SITE FOR RESIDUE A92 A 351 source : AC1 8) chain A residue 235 type sequence Y description BINDING SITE FOR RESIDUE A92 A 351 source : AC1 9) chain A residue 236 type sequence F description BINDING SITE FOR RESIDUE A92 A 351 source : AC1 10) chain A residue 243 type sequence S description BINDING SITE FOR RESIDUE A92 A 351 source : AC1 11) chain A residue 246 type sequence Y description BINDING SITE FOR RESIDUE A92 A 351 source : AC1 12) chain A residue 121 type MOD_RES sequence S description Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163 source Swiss-Prot : SWS_FT_FI3 13) chain A residue 201 type BINDING sequence H description BINDING => ECO:0000250|UniProtKB:Q9UGN5 source Swiss-Prot : SWS_FT_FI2 14) chain A residue 210 type BINDING sequence G description BINDING => ECO:0000250|UniProtKB:Q9UGN5 source Swiss-Prot : SWS_FT_FI2 15) chain A residue 217 type BINDING sequence R description BINDING => ECO:0000250|UniProtKB:Q9UGN5 source Swiss-Prot : SWS_FT_FI2 16) chain A residue 243 type BINDING sequence S description BINDING => ECO:0000250|UniProtKB:Q9UGN5 source Swiss-Prot : SWS_FT_FI2 17) chain A residue 125 type MOD_RES sequence S description Phosphoserine => ECO:0007744|PubMed:23186163 source Swiss-Prot : SWS_FT_FI4 18) chain A residue 87 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternate => ECO:0007744|PubMed:25218447, ECO:0007744|PubMed:28112733 source Swiss-Prot : SWS_FT_FI5 19) chain A residue 327 type ACT_SITE sequence E description For poly [ADP-ribose] polymerase activity => ECO:0000305|PubMed:32028527, ECO:0000305|PubMed:7852410, ECO:0000305|PubMed:9315851 source Swiss-Prot : SWS_FT_FI1

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