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eF-site ID
|
3kys-ABCD |
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PDB Code
|
3kys |
|
Chain
|
A, B, C, D |
|
click to enlarge
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Title
|
Crystal structure of human YAP and TEAD complex |
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Classification
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TRANSCRIPTION/PROTEIN BINDING |
|
Compound
|
Transcriptional enhancer factor TEF-1 |
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Source
|
(YAP1_HUMAN) |
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Sequence
|
A: |
SIGTTKLRLVEFSAFLEQQRDPDSYNKHLFVHIGHLESVD
IRQIYDKFPEKKGGLKELFGKGPQNAFFLVKFWADLNCNI
QDDAGAFYGVTSQYESSENMTVTCSTKVCSFGKQVVEKVE
TEYARFENGRFVYRINRSPMXEYMINFIHKLKHLPEKYMM
NSVLENFTILLVVTNRDTQETLLCMACVFEVSNSEHGAQH
HIYRLVKD
|
| B: |
GHQIVHVRGDSETDLEALFNAVMNPKTANVPQTVPMRLRK
LPDSFFKPPE
|
| C: |
RSIGTTKLRLVEFSAFLEQQRDPDSYNKHLFVHIGHALLE
SVDIRQIYDKFPEKKGGLKELFGKGPQNAFFLVKFWADLN
CNIQDDAGAFYGVTSQYESSENMTVTCSTKVCSFGKQVVE
KVETEYARFENGRFVYRINRSPMXEYMINFIHKLKHLPEK
YMMNSVLENFTILLVVTNRDTQETLLCMACVFEVSNSEHG
AQHHIYRLVKD
|
| D: |
HQIVHVRGDSETDLEALFNAVMNPKTANVPQTVPMRLRKL
PDSFFKPPE
|
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Description
|
(1) |
Transcriptional enhancer factor TEF-1, 65 kDa Yes-associated protein
|
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Functional site
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|
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1)
|
chain |
B |
| residue |
61 |
| type |
MOD_RES |
| sequence |
S
|
| description |
Phosphoserine; by LATS1 and LATS2 => ECO:0000269|PubMed:17974916, ECO:0000269|PubMed:18158288, ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
|
2)
|
chain |
D |
| residue |
61 |
| type |
MOD_RES |
| sequence |
S
|
| description |
Phosphoserine; by LATS1 and LATS2 => ECO:0000269|PubMed:17974916, ECO:0000269|PubMed:18158288, ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
|
3)
|
chain |
B |
| residue |
63 |
| type |
MOD_RES |
| sequence |
T
|
| description |
Phosphothreonine => ECO:0007744|PubMed:20068231
|
| source |
Swiss-Prot : SWS_FT_FI2
|
|
|
4)
|
chain |
D |
| residue |
63 |
| type |
MOD_RES |
| sequence |
T
|
| description |
Phosphothreonine => ECO:0007744|PubMed:20068231
|
| source |
Swiss-Prot : SWS_FT_FI2
|
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