eF-site ID 3kwz-A PDB Code 3kwz Chain A click to enlarge Title Cathepsin K in complex with a non-selective 2-cyano-pyrimidine inhibitor Classification HYDROLASE Compound Cathepsin K Source Homo sapiens (Human) (CATK_HUMAN) Sequence A:  APDSVDYRKKGYVTPVKNQGQCGSCWAFSSVGALEGQLKK KTGKLLNLSPQNLVDCVSENDGCGGGYMTNAFQYVQKNRG IDSEDAYPYVGQEESCMYNPTGKAAKCRGYREIPEGNEKA LKRAVARVGPVSVAIDASLTSFQFYSKGVYYDESCNSDNL NHAVLAVGYGIQKGNKHWIIKNSWGENWGNKGYILMARNK NNACGIANLASFPKM Description Functional site 1) chain A residue 19 type sequence Q description BINDING SITE FOR RESIDUE SO4 A 216 source : AC1 2) chain A residue 127 type sequence R description BINDING SITE FOR RESIDUE SO4 A 216 source : AC1 3) chain A residue 162 type sequence H description BINDING SITE FOR RESIDUE SO4 A 216 source : AC1 4) chain A residue 184 type sequence W description BINDING SITE FOR RESIDUE SO4 A 216 source : AC1 5) chain A residue 18 type sequence N description BINDING SITE FOR RESIDUE SO4 A 217 source : AC2 6) chain A residue 111 type sequence R description BINDING SITE FOR RESIDUE SO4 A 217 source : AC2 7) chain A residue 185 type sequence G description BINDING SITE FOR RESIDUE SO4 A 217 source : AC2 8) chain A residue 186 type sequence E description BINDING SITE FOR RESIDUE SO4 A 217 source : AC2 9) chain A residue 187 type sequence N description BINDING SITE FOR RESIDUE SO4 A 217 source : AC2 10) chain A residue 214 type sequence K description BINDING SITE FOR RESIDUE SO4 A 217 source : AC2 11) chain A residue 2 type sequence P description BINDING SITE FOR RESIDUE SO4 A 218 source : AC3 12) chain A residue 3 type sequence D description BINDING SITE FOR RESIDUE SO4 A 218 source : AC3 13) chain A residue 139 type sequence L description BINDING SITE FOR RESIDUE SO4 A 218 source : AC3 14) chain A residue 140 type sequence T description BINDING SITE FOR RESIDUE SO4 A 218 source : AC3 15) chain A residue 141 type sequence S description BINDING SITE FOR RESIDUE SO4 A 218 source : AC3 16) chain A residue 10 type sequence K description BINDING SITE FOR RESIDUE SO4 A 219 source : AC4 17) chain A residue 144 type sequence F description BINDING SITE FOR RESIDUE SO4 A 219 source : AC4 18) chain A residue 145 type sequence Y description BINDING SITE FOR RESIDUE SO4 A 219 source : AC4 19) chain A residue 146 type sequence S description BINDING SITE FOR RESIDUE SO4 A 219 source : AC4 20) chain A residue 147 type sequence K description BINDING SITE FOR RESIDUE SO4 A 219 source : AC4 21) chain A residue 92 type sequence Q description BINDING SITE FOR RESIDUE SO4 A 220 source : AC5 22) chain A residue 93 type sequence E description BINDING SITE FOR RESIDUE SO4 A 220 source : AC5 23) chain A residue 173 type sequence K description BINDING SITE FOR RESIDUE SO4 A 220 source : AC5 24) chain A residue 117 type sequence N description BINDING SITE FOR RESIDUE SO4 A 221 source : AC6 25) chain A residue 119 type sequence K description BINDING SITE FOR RESIDUE SO4 A 221 source : AC6 26) chain A residue 123 type sequence R description BINDING SITE FOR RESIDUE SO4 A 221 source : AC6 27) chain A residue 19 type sequence Q description BINDING SITE FOR RESIDUE KWZ A 222 source : AC7 28) chain A residue 23 type sequence G description BINDING SITE FOR RESIDUE KWZ A 222 source : AC7 29) chain A residue 25 type sequence C description BINDING SITE FOR RESIDUE KWZ A 222 source : AC7 30) chain A residue 64 type sequence G description BINDING SITE FOR RESIDUE KWZ A 222 source : AC7 31) chain A residue 65 type sequence G description BINDING SITE FOR RESIDUE KWZ A 222 source : AC7 32) chain A residue 66 type sequence G description BINDING SITE FOR RESIDUE KWZ A 222 source : AC7 33) chain A residue 67 type sequence Y description BINDING SITE FOR RESIDUE KWZ A 222 source : AC7 34) chain A residue 68 type sequence M description BINDING SITE FOR RESIDUE KWZ A 222 source : AC7 35) chain A residue 134 type sequence A description BINDING SITE FOR RESIDUE KWZ A 222 source : AC7 36) chain A residue 160 type sequence L description BINDING SITE FOR RESIDUE KWZ A 222 source : AC7 37) chain A residue 161 type sequence N description BINDING SITE FOR RESIDUE KWZ A 222 source : AC7 38) chain A residue 162 type sequence H description BINDING SITE FOR RESIDUE KWZ A 222 source : AC7 39) chain A residue 163 type sequence A description BINDING SITE FOR RESIDUE KWZ A 222 source : AC7 40) chain A residue 209 type sequence L description BINDING SITE FOR RESIDUE KWZ A 222 source : AC7 41) chain A residue 25 type ACT_SITE sequence C description ACT_SITE => ECO:0000250 source Swiss-Prot : SWS_FT_FI1 42) chain A residue 162 type ACT_SITE sequence H description ACT_SITE => ECO:0000250 source Swiss-Prot : SWS_FT_FI1 43) chain A residue 182 type ACT_SITE sequence N description ACT_SITE => ECO:0000250 source Swiss-Prot : SWS_FT_FI1 44) chain A residue 19-30 type prosite sequence QGQCGSCWAFSS description THIOL_PROTEASE_CYS Eukaryotic thiol (cysteine) proteases cysteine active site. QGqCGSCWAfSS source prosite : PS00139 45) chain A residue 160-170 type prosite sequence LNHAVLAVGYG description THIOL_PROTEASE_HIS Eukaryotic thiol (cysteine) proteases histidine active site. LNHAVLAVGYG source prosite : PS00639 46) chain A residue 177-196 type prosite sequence HWIIKNSWGENWGNKGYILM description THIOL_PROTEASE_ASN Eukaryotic thiol (cysteine) proteases asparagine active site. HWIiKNSWgenWGnkGYIlM source prosite : PS00640

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