eF-site/Summary 3kw5-A

eF-site ID	3kw5-A
PDB Code	3kw5
Chain	A

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Title	Crystal structure of ubiquitin carboxy terminal hydrolase L1 bound to ubiquitin vinylmethylester
Classification	HYDROLASE/SIGNALING PROTEIN
Compound	Ubiquitin carboxyl-terminal hydrolase isozyme L1
Source	Homo sapiens (Human) (UBIQ_HUMAN)

Sequence	A:	MQLKPMEINPEMLNKVLSRLGVAGQWRFVDVLGLEEESLG SVPAPACALLLLFPLTAQHENFRKKQIEELKGQEVSPKVY FMKQTIGNSCGTIGLIHAVANNQDKLGFEDGSVLKQFLSE TEKMSPEDRAKCFEKNEAIQAAHDAVAQEGQCRVDDKVNF HFILFNNVDGHLYELDGRMPFPVNHGASSEDTLLKDAAKV CREFTEREQGEVRFSAVALCKAA

Description

Functional site


1)	chain	A
	residue	84
	type
	sequence	Q
	description	BINDING SITE FOR RESIDUE GVE B 76
	source	: AC1

2)	chain	A
	residue	88
	type
	sequence	N
	description	BINDING SITE FOR RESIDUE GVE B 76
	source	: AC1

3)	chain	A
	residue	90
	type
	sequence	C
	description	BINDING SITE FOR RESIDUE GVE B 76
	source	: AC1

4)	chain	A
	residue	159
	type
	sequence	N
	description	BINDING SITE FOR RESIDUE GVE B 76
	source	: AC1

5)	chain	A
	residue	160
	type
	sequence	F
	description	BINDING SITE FOR RESIDUE GVE B 76
	source	: AC1

6)	chain	A
	residue	161
	type
	sequence	H
	description	BINDING SITE FOR RESIDUE GVE B 76
	source	: AC1

7)	chain	A
	residue	6
	type	MOD_RES
	sequence	M
	description	Phosphoserine; by PINK1 => ECO:0000269\|PubMed:24660806, ECO:0000269\|PubMed:24751536, ECO:0000269\|PubMed:24784582, ECO:0000269\|PubMed:25527291
	source	Swiss-Prot : SWS_FT_FI3

8)	chain	A
	residue	12
	type	MOD_RES
	sequence	M
	description	Phosphoserine; by PINK1 => ECO:0000269\|PubMed:24660806, ECO:0000269\|PubMed:24751536, ECO:0000269\|PubMed:24784582, ECO:0000269\|PubMed:25527291
	source	Swiss-Prot : SWS_FT_FI3

9)	chain	A
	residue	124
	type	MOD_RES
	sequence	M
	description	Phosphoserine; by PINK1 => ECO:0000269\|PubMed:24660806, ECO:0000269\|PubMed:24751536, ECO:0000269\|PubMed:24784582, ECO:0000269\|PubMed:25527291
	source	Swiss-Prot : SWS_FT_FI3

10)	chain	A
	residue	179
	type	MOD_RES
	sequence	M
	description	Phosphoserine; by PINK1 => ECO:0000269\|PubMed:24660806, ECO:0000269\|PubMed:24751536, ECO:0000269\|PubMed:24784582, ECO:0000269\|PubMed:25527291
	source	Swiss-Prot : SWS_FT_FI3

11)	chain	A
	residue	220
	type	MOD_RES
	sequence	C
	description	Phosphoserine; by PINK1 => ECO:0000269\|PubMed:24660806, ECO:0000269\|PubMed:24751536, ECO:0000269\|PubMed:24784582, ECO:0000269\|PubMed:25527291
	source	Swiss-Prot : SWS_FT_FI3

12)	chain	A
	residue	84-100
	type	prosite
	sequence	QTIGNSCGTIGLIHAVA
	description	UCH_1 Ubiquitin carboxyl-terminal hydrolase family 1 cysteine active-site. QtigNSCGtigLIHAVA
	source	prosite : PS00140

13)	chain	A
	residue	220
	type	CROSSLNK
	sequence	C
	description	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269\|PubMed:16543144, ECO:0000269\|PubMed:18719106
	source	Swiss-Prot : SWS_FT_FI6