eF-site ID 3kvx-A PDB Code 3kvx Chain A click to enlarge Title JNK3 bound to aminopyrimidine inhibitor, SR-3562 Classification TRANSFERASE Compound Mitogen-activated protein kinase 10 Source null (MK10_HUMAN) Sequence A:  NQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAV LDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIIS LLNVFTPQKTLEEFQDVYLVMELMDANLXQVIQMELDHER MSYLLYQMLXGIKHLHSAGIIHRDLKPSNIVVKSDXTLKI LDFGLARVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMV RHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNY VENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLS KMLVIDPAKRISVDDALQHPYINVWYDPAEEREHTIEEWK ELIYKEVMNS Description Functional site 1) chain A residue 70 type sequence I description BINDING SITE FOR RESIDUE FMY A 403 source : AC1 2) chain A residue 72 type sequence S description BINDING SITE FOR RESIDUE FMY A 403 source : AC1 3) chain A residue 73 type sequence G description BINDING SITE FOR RESIDUE FMY A 403 source : AC1 4) chain A residue 74 type sequence A description BINDING SITE FOR RESIDUE FMY A 403 source : AC1 5) chain A residue 75 type sequence Q description BINDING SITE FOR RESIDUE FMY A 403 source : AC1 6) chain A residue 78 type sequence V description BINDING SITE FOR RESIDUE FMY A 403 source : AC1 7) chain A residue 91 type sequence A description BINDING SITE FOR RESIDUE FMY A 403 source : AC1 8) chain A residue 93 type sequence K description BINDING SITE FOR RESIDUE FMY A 403 source : AC1 9) chain A residue 147 type sequence E description BINDING SITE FOR RESIDUE FMY A 403 source : AC1 10) chain A residue 149 type sequence M description BINDING SITE FOR RESIDUE FMY A 403 source : AC1 11) chain A residue 151 type sequence A description BINDING SITE FOR RESIDUE FMY A 403 source : AC1 12) chain A residue 155 type sequence Q description BINDING SITE FOR RESIDUE FMY A 403 source : AC1 13) chain A residue 193 type sequence S description BINDING SITE FOR RESIDUE FMY A 403 source : AC1 14) chain A residue 206 type sequence L description BINDING SITE FOR RESIDUE FMY A 403 source : AC1 15) chain A residue 185-197 type prosite sequence IIHRDLKPSNIVV description PROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. IiHrDLKpsNIVV source prosite : PS00108 16) chain A residue 99-201 type prosite sequence FQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEE FQDVYLVMELMDANLXQVIQMELDHERMSYLLYQMLXGIK HLHSAGIIHRDLKPSNIVVKSDX description MAPK MAP kinase signature. FqnqthakrayRElvlmkcvnhkniisllnvftpqktleefqdvylvmelmdanlcqviqmeldhermsyllyqmlcgikhlhsagiih..........RDlKpsnivvksdC source prosite : PS01351 17) chain A residue 189 type ACT_SITE sequence D description Proton acceptor source Swiss-Prot : SWS_FT_FI1 18) chain A residue 93 type BINDING sequence K description source Swiss-Prot : SWS_FT_FI2 19) chain A residue 70 type BINDING sequence I description source Swiss-Prot : SWS_FT_FI2

Display surface Download Links