eF-site ID 3ktm-H PDB Code 3ktm Chain H click to enlarge Title Structure of the Heparin-induced E1-Dimer of the Amyloid Precursor Protein (APP) Classification CELL ADHESION, SIGNALING PROTEIN Compound Amyloid beta A4 protein Source Homo sapiens (Human) (A4_HUMAN) Sequence H:  AGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTKTCIDT KEGILQYCQEVYPELQITNVVEANQPVTIQNWCKRGRKQC KTHPHFVIPYRCLVGEFVSDALLVPDKCKFLHQERMDVCE THLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFRGVEFV CCPLAIEGRKLAAAL Description Functional site 1) chain H residue 194 type sequence R description BINDING SITE FOR RESIDUE SO4 B 2 source : AC3 2) chain H residue 189 type sequence L description BINDING SITE FOR RESIDUE BU4 H 8 source : BC6 3) chain H residue 190 type sequence A description BINDING SITE FOR RESIDUE BU4 H 8 source : BC6 4) chain H residue 88 type sequence A description BINDING SITE FOR RESIDUE SO4 H 1 source : BC7 5) chain H residue 89 type sequence N description BINDING SITE FOR RESIDUE SO4 H 1 source : BC7 6) chain H residue 116 type sequence R description BINDING SITE FOR RESIDUE SO4 H 1 source : BC7 7) chain H residue 90 type sequence Q description BINDING SITE FOR RESIDUE ACT H 6 source : BC8 8) chain H residue 151 type sequence H description BINDING SITE FOR RESIDUE ACT H 6 source : BC8 9) chain H residue 155 type sequence K description BINDING SITE FOR RESIDUE ACT H 6 source : BC8 10) chain H residue 96 type BINDING sequence N description BINDING => ECO:0000269|PubMed:8158260 source Swiss-Prot : SWS_FT_FI1 11) chain H residue 168 type BINDING sequence Y description BINDING => ECO:0000255|PROSITE-ProRule:PRU01217, ECO:0000269|PubMed:17239395, ECO:0007744|PDB:2FK1 source Swiss-Prot : SWS_FT_FI3 12) chain H residue 147 type BINDING sequence H description BINDING => ECO:0000255|PROSITE-ProRule:PRU01217, ECO:0000269|PubMed:17239395, ECO:0000269|PubMed:25122912, ECO:0007744|PDB:2FK1 source Swiss-Prot : SWS_FT_FI2 13) chain H residue 151 type BINDING sequence H description BINDING => ECO:0000255|PROSITE-ProRule:PRU01217, ECO:0000269|PubMed:17239395, ECO:0000269|PubMed:25122912, ECO:0007744|PDB:2FK1 source Swiss-Prot : SWS_FT_FI2 14) chain H residue 183 type BINDING sequence E description BINDING => ECO:0000305|PubMed:8344894 source Swiss-Prot : SWS_FT_FI4 15) chain H residue 186 type BINDING sequence C description BINDING => ECO:0000305|PubMed:8344894 source Swiss-Prot : SWS_FT_FI4 16) chain H residue 187 type BINDING sequence C description BINDING => ECO:0000305|PubMed:8344894 source Swiss-Prot : SWS_FT_FI4 17) chain H residue 170 type SITE sequence M description Required for Cu(2+) reduction => ECO:0000255|PROSITE-ProRule:PRU01217 source Swiss-Prot : SWS_FT_FI5

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