eF-site ID 3ktm-F PDB Code 3ktm Chain F click to enlarge Title Structure of the Heparin-induced E1-Dimer of the Amyloid Precursor Protein (APP) Classification CELL ADHESION, SIGNALING PROTEIN Compound Amyloid beta A4 protein Source Homo sapiens (Human) (A4_HUMAN) Sequence F:  LLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTKTCIDTKE GILQYCQEVYPELQITNVVEANQPVTIQNWCKRGRKQCKT HPHFVIPYRCLVGEFVSDALLVPDKCKFLHQERMDVCETH LHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFRGVEFVCC PLAIEGRKLAAALEH Description Functional site 1) chain F residue 194 type sequence R description BINDING SITE FOR RESIDUE BU4 E 6 source : BC1 2) chain F residue 175 type sequence G description BINDING SITE FOR RESIDUE BU4 F 4 source : BC4 3) chain F residue 176 type sequence I description BINDING SITE FOR RESIDUE BU4 F 4 source : BC4 4) chain F residue 96 type BINDING sequence N description BINDING => ECO:0000269|PubMed:8158260 source Swiss-Prot : SWS_FT_FI1 5) chain F residue 168 type BINDING sequence Y description BINDING => ECO:0000255|PROSITE-ProRule:PRU01217, ECO:0000269|PubMed:17239395, ECO:0007744|PDB:2FK1 source Swiss-Prot : SWS_FT_FI3 6) chain F residue 147 type BINDING sequence H description BINDING => ECO:0000255|PROSITE-ProRule:PRU01217, ECO:0000269|PubMed:17239395, ECO:0000269|PubMed:25122912, ECO:0007744|PDB:2FK1 source Swiss-Prot : SWS_FT_FI2 7) chain F residue 151 type BINDING sequence H description BINDING => ECO:0000255|PROSITE-ProRule:PRU01217, ECO:0000269|PubMed:17239395, ECO:0000269|PubMed:25122912, ECO:0007744|PDB:2FK1 source Swiss-Prot : SWS_FT_FI2 8) chain F residue 183 type BINDING sequence E description BINDING => ECO:0000305|PubMed:8344894 source Swiss-Prot : SWS_FT_FI4 9) chain F residue 186 type BINDING sequence C description BINDING => ECO:0000305|PubMed:8344894 source Swiss-Prot : SWS_FT_FI4 10) chain F residue 187 type BINDING sequence C description BINDING => ECO:0000305|PubMed:8344894 source Swiss-Prot : SWS_FT_FI4 11) chain F residue 170 type SITE sequence M description Required for Cu(2+) reduction => ECO:0000255|PROSITE-ProRule:PRU01217 source Swiss-Prot : SWS_FT_FI5

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