eF-site ID 3ktm-E PDB Code 3ktm Chain E click to enlarge Title Structure of the Heparin-induced E1-Dimer of the Amyloid Precursor Protein (APP) Classification CELL ADHESION, SIGNALING PROTEIN Compound Amyloid beta A4 protein Source Homo sapiens (Human) (A4_HUMAN) Sequence E:  AGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTKTCIDT KEGILQYCQEVYPELQITNVVEANQPVTIQNWCKRGRKQC KTHPHFVIPYRCLVGEFVSDALLVPDKCKFLHQERMDVCE THLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFRGVEFV CCPLAIEGRKLAAALEH Description Functional site 1) chain E residue 194 type sequence R description BINDING SITE FOR RESIDUE SO4 C 3 source : AC6 2) chain E residue 155 type sequence K description BINDING SITE FOR RESIDUE ACT C 8 source : AC7 3) chain E residue 189 type sequence L description BINDING SITE FOR RESIDUE BU4 E 6 source : BC1 4) chain E residue 190 type sequence A description BINDING SITE FOR RESIDUE BU4 E 6 source : BC1 5) chain E residue 88 type sequence A description BINDING SITE FOR RESIDUE SO4 E 4 source : BC2 6) chain E residue 89 type sequence N description BINDING SITE FOR RESIDUE SO4 E 4 source : BC2 7) chain E residue 116 type sequence R description BINDING SITE FOR RESIDUE SO4 E 4 source : BC2 8) chain E residue 90 type sequence Q description BINDING SITE FOR RESIDUE ACT E 9 source : BC3 9) chain E residue 151 type sequence H description BINDING SITE FOR RESIDUE ACT E 9 source : BC3 10) chain E residue 155 type sequence K description BINDING SITE FOR RESIDUE ACT E 9 source : BC3 11) chain E residue 96 type BINDING sequence N description BINDING => ECO:0000269|PubMed:8158260 source Swiss-Prot : SWS_FT_FI1 12) chain E residue 168 type BINDING sequence Y description BINDING => ECO:0000255|PROSITE-ProRule:PRU01217, ECO:0000269|PubMed:17239395, ECO:0007744|PDB:2FK1 source Swiss-Prot : SWS_FT_FI3 13) chain E residue 151 type BINDING sequence H description BINDING => ECO:0000255|PROSITE-ProRule:PRU01217, ECO:0000269|PubMed:17239395, ECO:0000269|PubMed:25122912, ECO:0007744|PDB:2FK1 source Swiss-Prot : SWS_FT_FI2 14) chain E residue 147 type BINDING sequence H description BINDING => ECO:0000255|PROSITE-ProRule:PRU01217, ECO:0000269|PubMed:17239395, ECO:0000269|PubMed:25122912, ECO:0007744|PDB:2FK1 source Swiss-Prot : SWS_FT_FI2 15) chain E residue 183 type BINDING sequence E description BINDING => ECO:0000305|PubMed:8344894 source Swiss-Prot : SWS_FT_FI4 16) chain E residue 186 type BINDING sequence C description BINDING => ECO:0000305|PubMed:8344894 source Swiss-Prot : SWS_FT_FI4 17) chain E residue 187 type BINDING sequence C description BINDING => ECO:0000305|PubMed:8344894 source Swiss-Prot : SWS_FT_FI4 18) chain E residue 170 type SITE sequence M description Required for Cu(2+) reduction => ECO:0000255|PROSITE-ProRule:PRU01217 source Swiss-Prot : SWS_FT_FI5

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