eF-site ID 3ktm-D PDB Code 3ktm Chain D click to enlarge Title Structure of the Heparin-induced E1-Dimer of the Amyloid Precursor Protein (APP) Classification CELL ADHESION, SIGNALING PROTEIN Compound Amyloid beta A4 protein Source Homo sapiens (Human) (A4_HUMAN) Sequence D:  LLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTKTCIDTKE GILQYCQEVYPELQITNVVEANQPVTIQNWCKRGRKQCKT HPHFVIPYRCLVGEFVSDALLVPDKCKFLHQERMDVCETH LHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFRGVEFVCC PLAIEGRKLAAAL Description Functional site 1) chain D residue 83 type sequence T description BINDING SITE FOR RESIDUE BU4 D 2 source : AC8 2) chain D residue 84 type sequence N description BINDING SITE FOR RESIDUE BU4 D 2 source : AC8 3) chain D residue 173 type sequence P description BINDING SITE FOR RESIDUE BU4 D 2 source : AC8 4) chain D residue 174 type sequence C description BINDING SITE FOR RESIDUE BU4 D 2 source : AC8 5) chain D residue 175 type sequence G description BINDING SITE FOR RESIDUE BU4 D 2 source : AC8 6) chain D residue 140 type sequence R description BINDING SITE FOR RESIDUE SO4 D 5 source : AC9 7) chain D residue 194 type sequence R description BINDING SITE FOR RESIDUE BU4 H 8 source : BC6 8) chain D residue 96 type BINDING sequence N description BINDING => ECO:0000269|PubMed:8158260 source Swiss-Prot : SWS_FT_FI1 9) chain D residue 147 type BINDING sequence H description BINDING => ECO:0000255|PROSITE-ProRule:PRU01217, ECO:0000269|PubMed:17239395, ECO:0000269|PubMed:25122912, ECO:0007744|PDB:2FK1 source Swiss-Prot : SWS_FT_FI2 10) chain D residue 151 type BINDING sequence H description BINDING => ECO:0000255|PROSITE-ProRule:PRU01217, ECO:0000269|PubMed:17239395, ECO:0000269|PubMed:25122912, ECO:0007744|PDB:2FK1 source Swiss-Prot : SWS_FT_FI2 11) chain D residue 168 type BINDING sequence Y description BINDING => ECO:0000255|PROSITE-ProRule:PRU01217, ECO:0000269|PubMed:17239395, ECO:0007744|PDB:2FK1 source Swiss-Prot : SWS_FT_FI3 12) chain D residue 183 type BINDING sequence E description BINDING => ECO:0000305|PubMed:8344894 source Swiss-Prot : SWS_FT_FI4 13) chain D residue 186 type BINDING sequence C description BINDING => ECO:0000305|PubMed:8344894 source Swiss-Prot : SWS_FT_FI4 14) chain D residue 187 type BINDING sequence C description BINDING => ECO:0000305|PubMed:8344894 source Swiss-Prot : SWS_FT_FI4 15) chain D residue 170 type SITE sequence M description Required for Cu(2+) reduction => ECO:0000255|PROSITE-ProRule:PRU01217 source Swiss-Prot : SWS_FT_FI5

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