eF-site ID 3ktm-C PDB Code 3ktm Chain C click to enlarge Title Structure of the Heparin-induced E1-Dimer of the Amyloid Precursor Protein (APP) Classification CELL ADHESION, SIGNALING PROTEIN Compound Amyloid beta A4 protein Source Homo sapiens (Human) (A4_HUMAN) Sequence C:  AGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTKTCIDT KEGILQYCQEVYPELQITNVVEANQPVTIQNWCKRGRKQC KTHPHFVIPYRCLVGEFVSDALLVPDKCKFLHQERMDVCE THLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFRGVEFV CCPLAIEGRKLAAA Description Functional site 1) chain C residue 189 type sequence L description BINDING SITE FOR RESIDUE BU4 C 5 source : AC5 2) chain C residue 190 type sequence A description BINDING SITE FOR RESIDUE BU4 C 5 source : AC5 3) chain C residue 89 type sequence N description BINDING SITE FOR RESIDUE SO4 C 3 source : AC6 4) chain C residue 116 type sequence R description BINDING SITE FOR RESIDUE SO4 C 3 source : AC6 5) chain C residue 90 type sequence Q description BINDING SITE FOR RESIDUE ACT C 8 source : AC7 6) chain C residue 151 type sequence H description BINDING SITE FOR RESIDUE ACT C 8 source : AC7 7) chain C residue 194 type sequence R description BINDING SITE FOR RESIDUE SO4 E 4 source : BC2 8) chain C residue 96 type BINDING sequence N description BINDING => ECO:0000269|PubMed:8158260 source Swiss-Prot : SWS_FT_FI1 9) chain C residue 147 type BINDING sequence H description BINDING => ECO:0000255|PROSITE-ProRule:PRU01217, ECO:0000269|PubMed:17239395, ECO:0000269|PubMed:25122912, ECO:0007744|PDB:2FK1 source Swiss-Prot : SWS_FT_FI2 10) chain C residue 151 type BINDING sequence H description BINDING => ECO:0000255|PROSITE-ProRule:PRU01217, ECO:0000269|PubMed:17239395, ECO:0000269|PubMed:25122912, ECO:0007744|PDB:2FK1 source Swiss-Prot : SWS_FT_FI2 11) chain C residue 168 type BINDING sequence Y description BINDING => ECO:0000255|PROSITE-ProRule:PRU01217, ECO:0000269|PubMed:17239395, ECO:0007744|PDB:2FK1 source Swiss-Prot : SWS_FT_FI3 12) chain C residue 183 type BINDING sequence E description BINDING => ECO:0000305|PubMed:8344894 source Swiss-Prot : SWS_FT_FI4 13) chain C residue 186 type BINDING sequence C description BINDING => ECO:0000305|PubMed:8344894 source Swiss-Prot : SWS_FT_FI4 14) chain C residue 187 type BINDING sequence C description BINDING => ECO:0000305|PubMed:8344894 source Swiss-Prot : SWS_FT_FI4 15) chain C residue 170 type SITE sequence M description Required for Cu(2+) reduction => ECO:0000255|PROSITE-ProRule:PRU01217 source Swiss-Prot : SWS_FT_FI5

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