eF-site ID 3ktm-A PDB Code 3ktm Chain A click to enlarge Title Structure of the Heparin-induced E1-Dimer of the Amyloid Precursor Protein (APP) Classification CELL ADHESION, SIGNALING PROTEIN Compound Amyloid beta A4 protein Source Homo sapiens (Human) (A4_HUMAN) Sequence A:  LLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTKTCIDTKE GILQYCQEVYPELQITNVVEANQPVTIQNWCKRGRKQCKT HPHFVIPYRCLVGEFVSDALLVPDKCKFLHQERMDVCETH LHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFRGVEFVCC PLAIEGRKLAAALEH Description Functional site 1) chain A residue 83 type sequence T description BINDING SITE FOR RESIDUE BU4 A 1 source : AC1 2) chain A residue 84 type sequence N description BINDING SITE FOR RESIDUE BU4 A 1 source : AC1 3) chain A residue 173 type sequence P description BINDING SITE FOR RESIDUE BU4 A 1 source : AC1 4) chain A residue 174 type sequence C description BINDING SITE FOR RESIDUE BU4 A 1 source : AC1 5) chain A residue 175 type sequence G description BINDING SITE FOR RESIDUE BU4 A 1 source : AC1 6) chain A residue 176 type sequence I description BINDING SITE FOR RESIDUE BU4 A 1 source : AC1 7) chain A residue 194 type sequence R description BINDING SITE FOR RESIDUE BU4 C 5 source : AC5 8) chain A residue 180 type sequence R description BINDING SITE FOR RESIDUE SO4 D 5 source : AC9 9) chain A residue 96 type BINDING sequence N description BINDING => ECO:0000269|PubMed:8158260 source Swiss-Prot : SWS_FT_FI1 10) chain A residue 168 type BINDING sequence Y description BINDING => ECO:0000255|PROSITE-ProRule:PRU01217, ECO:0000269|PubMed:17239395, ECO:0007744|PDB:2FK1 source Swiss-Prot : SWS_FT_FI3 11) chain A residue 147 type BINDING sequence H description BINDING => ECO:0000255|PROSITE-ProRule:PRU01217, ECO:0000269|PubMed:17239395, ECO:0000269|PubMed:25122912, ECO:0007744|PDB:2FK1 source Swiss-Prot : SWS_FT_FI2 12) chain A residue 151 type BINDING sequence H description BINDING => ECO:0000255|PROSITE-ProRule:PRU01217, ECO:0000269|PubMed:17239395, ECO:0000269|PubMed:25122912, ECO:0007744|PDB:2FK1 source Swiss-Prot : SWS_FT_FI2 13) chain A residue 181-188 type prosite sequence GVEFVCCP description APP_CUBD Amyloid precursor protein (APP) copper-binding (CuBD) domain signature. GVEFVCCP source prosite : PS00319 14) chain A residue 183 type BINDING sequence E description BINDING => ECO:0000305|PubMed:8344894 source Swiss-Prot : SWS_FT_FI4 15) chain A residue 186 type BINDING sequence C description BINDING => ECO:0000305|PubMed:8344894 source Swiss-Prot : SWS_FT_FI4 16) chain A residue 187 type BINDING sequence C description BINDING => ECO:0000305|PubMed:8344894 source Swiss-Prot : SWS_FT_FI4 17) chain A residue 170 type SITE sequence M description Required for Cu(2+) reduction => ECO:0000255|PROSITE-ProRule:PRU01217 source Swiss-Prot : SWS_FT_FI5

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