eF-site ID 3kt1-A PDB Code 3kt1 Chain A click to enlarge Title Crystal structure of Tpa1 from Saccharomyces cerevisiae, a component of the messenger ribonucleoprotein complex Classification OXIDOREDUCTASE Compound PKHD-type hydroxylase TPA1 Source Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (TPA1_YEAST) Sequence A:  DKIKGMFNPKIWDKTFQDGLKKEIEDSQPYNWGTIHELVN DDLLRAVRKEIETEIHFTKKETDIYRVNQSGDLANLSGLD WDDLSRLPNLFKLRQILYSKQYRDFFGYVTKAGKLSGSKT DMSINTYTKGCHLLTHDDVIGSRRISFILYLPDPDRKWKS HYGGGLRLFPSILPNVPHSDPSAKLVPQFNQIAFFKVLPG FSFHDVEEVKVDKHRLSIQGWYHIPQVGEEGYIPGEEEAW VRNNTNVLEDFEFPKDERNILSFHEVKHFEKMLKVKLSEA EFTYLSQYISPEHLSSKGIEKLQKQFVENSSLQIESFLND DKSELLKKVIKQKELEQECPYHSKDVKAPWKTAIPPHKAR YLYIDGKEYRNFQTEADILEALNNNDLPNFQFTKDAIKII SDASGNSRENNFDAELALIDLAVFHKSTIFKKYLALLTSL CPVSEQILIRRFRPGMDFTLATKCRFNELLKSNPDIIDAV LEGTLCLTPSAGWESGELGGYELYMMDDSVLINDPPAWNT FNLVLRDESVLEFVKYVSWSAKSSRWDVKMKWDVKSC Description (1)  PKHD-type hydroxylase TPA1 (E.C.1.14.11.-) Functional site 1) chain A residue 159 type sequence H description BINDING SITE FOR RESIDUE FE A 653 source : AC1 2) chain A residue 161 type sequence D description BINDING SITE FOR RESIDUE FE A 653 source : AC1 3) chain A residue 227 type sequence H description BINDING SITE FOR RESIDUE FE A 653 source : AC1 4) chain A residue 179 type sequence R description BINDING SITE FOR RESIDUE SO4 A 654 source : AC2 5) chain A residue 180 type sequence K description BINDING SITE FOR RESIDUE SO4 A 654 source : AC2 6) chain A residue 182 type sequence K description BINDING SITE FOR RESIDUE SO4 A 654 source : AC2 7) chain A residue 545 type sequence G description BINDING SITE FOR RESIDUE SO4 A 655 source : AC3 8) chain A residue 545 type sequence G description BINDING SITE FOR RESIDUE SO4 A 655 source : AC3 9) chain A residue 546 type sequence W description BINDING SITE FOR RESIDUE SO4 A 655 source : AC3 10) chain A residue 546 type sequence W description BINDING SITE FOR RESIDUE SO4 A 655 source : AC3 11) chain A residue 547 type sequence E description BINDING SITE FOR RESIDUE SO4 A 655 source : AC3 12) chain A residue 547 type sequence E description BINDING SITE FOR RESIDUE SO4 A 655 source : AC3 13) chain A residue 548 type sequence S description BINDING SITE FOR RESIDUE SO4 A 655 source : AC3 14) chain A residue 548 type sequence S description BINDING SITE FOR RESIDUE SO4 A 655 source : AC3 15) chain A residue 152 type sequence K description BINDING SITE FOR RESIDUE SO4 A 656 source : AC4 16) chain A residue 234 type sequence V description BINDING SITE FOR RESIDUE SO4 A 656 source : AC4 17) chain A residue 235 type sequence D description BINDING SITE FOR RESIDUE SO4 A 656 source : AC4 18) chain A residue 180 type sequence K description BINDING SITE FOR RESIDUE SO4 A 657 source : AC5 19) chain A residue 182 type sequence K description BINDING SITE FOR RESIDUE SO4 A 657 source : AC5 20) chain A residue 183 type sequence S description BINDING SITE FOR RESIDUE SO4 A 657 source : AC5 21) chain A residue 444 type sequence Q description BINDING SITE FOR RESIDUE GOL A 658 source : AC6 22) chain A residue 447 type sequence K description BINDING SITE FOR RESIDUE GOL A 658 source : AC6 23) chain A residue 159 type BINDING sequence H description BINDING => ECO:0000255|PROSITE-ProRule:PRU00805, ECO:0000269|PubMed:20040577, ECO:0000269|PubMed:25728928 source Swiss-Prot : SWS_FT_FI1 24) chain A residue 161 type BINDING sequence D description BINDING => ECO:0000255|PROSITE-ProRule:PRU00805, ECO:0000269|PubMed:20040577, ECO:0000269|PubMed:25728928 source Swiss-Prot : SWS_FT_FI1 25) chain A residue 227 type BINDING sequence H description BINDING => ECO:0000255|PROSITE-ProRule:PRU00805, ECO:0000269|PubMed:20040577, ECO:0000269|PubMed:25728928 source Swiss-Prot : SWS_FT_FI1 26) chain A residue 173 type BINDING sequence Y description BINDING => ECO:0000269|PubMed:20040577 source Swiss-Prot : SWS_FT_FI2 27) chain A residue 238 type BINDING sequence R description BINDING => ECO:0000255|PROSITE-ProRule:PRU00805, ECO:0000269|PubMed:20040577 source Swiss-Prot : SWS_FT_FI3 28) chain A residue 607 type MOD_RES sequence S description Phosphoserine => ECO:0007744|PubMed:18407956 source Swiss-Prot : SWS_FT_FI4

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