eF-site ID 3krx-ABG PDB Code 3krx Chain A, B, G click to enlarge Title Human GRK2 in complex with Gbetgamma subunits and balanol (co-crystal) Classification PROTEIN BINDING Compound Beta-adrenergic receptor kinase 1 Source Homo sapiens (Human) (GBG2_BOVIN) Sequence A:  KKILLPEPSIRSVMQKYLEDRGEVTFEKIFSQKLGYLLFR DFCLNHLEEARPLVEFYEEIKKYEKLETEEERVARSREIF DSYIMKELLAHPFSKSATEHVQGHLGKKQVPPDLFQPYIE EICQNLRGDVFQKFIESDKFTRFCQWKNVELNIHLTMNDF SVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQ GETLALNERIMLSLVSTGDCPFIVCMSYAFHTPDKLSFIL DLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLEHMHNR FVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASV GTHGYMAPEVLQKGVAYDSSADWFSLGCMLFKLLRGHSPF RQHKTKDKHEIDRMTLTMAVELPDSFSPELRSLLEGLLQR DVNRRLGCLGRGAQEVKESPFFRSLDWQMVFLQKYPPPLI PPREEDTKGIKLLDSDQELYRNFPLTISERWQQEVAETVF DTINAETDRLEARKKAKNKQLGHEEDYALGKDCIMHGYMS KMWQRRYFYLFPNRLEWRGEGEAPQSLLTMEEIQSVEETQ IKERKCLLLKIRGGKQFILQCDSDPELVQWKKELRDAYRE AQQLVQRVPKMKNKPRSP B:  ELDQLRQEAEQLKNQIRDARKACADATLSQITNNIDPVGR IQMRTRRTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIW DSYTTNKVHAIPLRSSWVMTCAYAPSGNYVACGGLDNICS IYNLKTREGNVRVSRELAGHTGYLSCCRFLDDNQIVTSSG DTTCALWDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSG ACDASAKLWDVREGMCRQTFTGHESDINAICFFPNGNAFA TGSDDATCRLFDLRADQELMTYSHDNIICGITSVSFSKSG RLLLAGYDDFNCNVWDALKADRAGVLAGHDNRVSCLGVTD DGMAVATGSWDSFLKIWN G:  SIAQARKLVEQLKMEANIDRIKVSKAAADLMAYCEAHAKE DPLLTPVPASENPFREKKFFX Description Functional site 1) chain A residue 197 type sequence I description BINDING SITE FOR RESIDUE BA1 A 690 source : AC1 2) chain A residue 198 type sequence G description BINDING SITE FOR RESIDUE BA1 A 690 source : AC1 3) chain A residue 199 type sequence R description BINDING SITE FOR RESIDUE BA1 A 690 source : AC1 4) chain A residue 201 type sequence G description BINDING SITE FOR RESIDUE BA1 A 690 source : AC1 5) chain A residue 202 type sequence F description BINDING SITE FOR RESIDUE BA1 A 690 source : AC1 6) chain A residue 203 type sequence G description BINDING SITE FOR RESIDUE BA1 A 690 source : AC1 7) chain A residue 205 type sequence V description BINDING SITE FOR RESIDUE BA1 A 690 source : AC1 8) chain A residue 218 type sequence A description BINDING SITE FOR RESIDUE BA1 A 690 source : AC1 9) chain A residue 220 type sequence K description BINDING SITE FOR RESIDUE BA1 A 690 source : AC1 10) chain A residue 239 type sequence E description BINDING SITE FOR RESIDUE BA1 A 690 source : AC1 11) chain A residue 272 type sequence D description BINDING SITE FOR RESIDUE BA1 A 690 source : AC1 12) chain A residue 273 type sequence L description BINDING SITE FOR RESIDUE BA1 A 690 source : AC1 13) chain A residue 274 type sequence M description BINDING SITE FOR RESIDUE BA1 A 690 source : AC1 14) chain A residue 321 type sequence A description BINDING SITE FOR RESIDUE BA1 A 690 source : AC1 15) chain A residue 324 type sequence L description BINDING SITE FOR RESIDUE BA1 A 690 source : AC1 16) chain A residue 334 type sequence S description BINDING SITE FOR RESIDUE BA1 A 690 source : AC1 17) chain A residue 335 type sequence D description BINDING SITE FOR RESIDUE BA1 A 690 source : AC1 18) chain A residue 337 type sequence G description BINDING SITE FOR RESIDUE BA1 A 690 source : AC1 19) chain A residue 348 type sequence H description BINDING SITE FOR RESIDUE MG A 691 source : AC2 20) chain A residue 360 type sequence E description BINDING SITE FOR RESIDUE MG A 691 source : AC2 21) chain A residue 361 type sequence V description BINDING SITE FOR RESIDUE MG A 691 source : AC2 22) chain A residue 363 type sequence Q description BINDING SITE FOR RESIDUE MG A 691 source : AC2 23) chain A residue 366 type sequence V description BINDING SITE FOR RESIDUE MG A 691 source : AC2 24) chain A residue 368 type sequence Y description BINDING SITE FOR RESIDUE MG A 691 source : AC2 25) chain A residue 670 type MOD_RES sequence S description Phosphoserine => ECO:0007744|PubMed:18088087, ECO:0007744|PubMed:23186163 source Swiss-Prot : SWS_FT_FI4 26) chain A residue 197-220 type prosite sequence IGRGGFGEVYGCRKADTGKMYAMK description PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. IGRGGFGEVYgCrkadtgkm..........YAMK source prosite : PS00107 27) chain A residue 313-325 type prosite sequence VVYRDLKPANILL description PROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. VvYrDLKpaNILL source prosite : PS00108 28) chain B residue 70-84 type prosite sequence LVSASQDGKLIIWDS description WD_REPEATS_1 Trp-Asp (WD) repeats signature. LVSAsqDgKLIIWDS source prosite : PS00678 29) chain B residue 157-171 type prosite sequence IVTSSGDTTCALWDI description WD_REPEATS_1 Trp-Asp (WD) repeats signature. LVSAsqDgKLIIWDS source prosite : PS00678 30) chain B residue 285-299 type prosite sequence LLAGYDDFNCNVWDA description WD_REPEATS_1 Trp-Asp (WD) repeats signature. LVSAsqDgKLIIWDS source prosite : PS00678 31) chain G residue 68 type MOD_RES sequence X description Cysteine methyl ester => ECO:0000269|PubMed:1903391 source Swiss-Prot : SWS_FT_FI2 32) chain A residue 220 type MOD_RES sequence K description Cysteine methyl ester => ECO:0000269|PubMed:1903391 source Swiss-Prot : SWS_FT_FI2 33) chain G residue 68 type LIPID sequence X description S-geranylgeranyl cysteine => ECO:0000269|PubMed:12764189, ECO:0000269|PubMed:1903391, ECO:0000269|PubMed:7626050 source Swiss-Prot : SWS_FT_FI3

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