|
|
eF-site ID
|
3kl6-B |
|
PDB Code
|
3kl6 |
|
Chain
|
B |
|
click to enlarge
|
|
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Title
|
Discovery of Tetrahydropyrimidin-2(1H)-one derivative TAK-442: A potent, selective and orally active factor Xa inhibitor |
|
Classification
|
HYDROLASE |
|
Compound
|
Coagulation Factor X heavy chain |
|
Source
|
null (FA10_HUMAN) |
|
|
Sequence
|
B: |
KLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIP
TGPYPCGKQT
|
|
|
Description
|
|
Functional site
|
|
|
1)
|
chain |
B |
| residue |
13 |
| type |
|
| sequence |
H
|
| description |
BINDING SITE FOR RESIDUE CA A 252
|
| source |
: AC5
|
|
|
2)
|
chain |
B |
| residue |
15 |
| type |
|
| sequence |
E
|
| description |
BINDING SITE FOR RESIDUE EDO B 903
|
| source |
: AC8
|
|
|
3)
|
chain |
B |
| residue |
21-36 |
| type |
prosite |
| sequence |
CSCARGYTLADNGKAC
|
| description |
EGF_2 EGF-like domain signature 2. CsCarGYtladngkaC
|
| source |
prosite : PS01186
|
|
|
|