eF-site ID 3kj6-AHL PDB Code 3kj6 Chain A, H, L click to enlarge Title Crystal structure of a Methylated beta2 Adrenergic Receptor-Fab complex Classification SIGNALING PROTEIN Compound Beta-2 adrenergic receptor Source null (3KJ6) Sequence A:  GMGIVMSLIVLAIVFGNVLVITAIAFERLQTVTNYFITSL ACADLVMGLAVVPFGAFWTSIDVLCVTASIETLCVIAVDR YFAITSPFKYQSLLTKNKARVIILMVWIVSGLTSSIVSFY VPLVIMVFVYSRVFQEAKRQLQKIDKSEGRFHVKFCLKEH KALKTLGIIMGTFTLCWLPFFIVYILLNWIGYVNSGFNPL IYCRSPDFRIAFQELLCLRRSS H:  EVQLQQSGAELARPGASVKLSCKASGYIFTDYYINWVRQR TGQGFEWIGEIYPGSGNIDYNERFKDKATLTADKSSSTAY MQLSSLTSEDSAVYFCVRGFGYWGQGTTLTVSSAKTTPPS VYPLAPGSAAQTNSAVTLGCLVKGYFPEPVTVTWNSGSLS SGVHTFPAVLQSDLYTLSSSVTVPSSTWPSETVTCNVAHP ASSTKVDKKIVPRDCGC L:  DIKMTQSPSSMYASLGERVTITCKASQDINSYLSWFQQKP GKSPKTLIYRANRLVDGVPSRFIGTGSGQDYSLTISSLDY ADMGIYYCLQYDEFPYTFGGGTKLEIKRADAAPTVSIFPP SSEQLTSGGASVVCFLNNFYPKDINVKWKIDGSERQNGVL NSWTDQDSKDSTYSMSSTLTLTKDEYERHNSYTCEATHKT STSPIVKSFNRNEC Description Functional site 1) chain A residue 66 type sequence T description BINDING SITE FOR RESIDUE SO4 A 1001 source : AC1 2) chain A residue 67 type sequence V description BINDING SITE FOR RESIDUE SO4 A 1001 source : AC1 3) chain A residue 68 type sequence T description BINDING SITE FOR RESIDUE SO4 A 1001 source : AC1 4) chain A residue 142 type sequence Q description BINDING SITE FOR RESIDUE SO4 A 1001 source : AC1 5) chain A residue 143 type sequence S description BINDING SITE FOR RESIDUE SO4 A 1001 source : AC1 6) chain A residue 35-58 type TRANSMEM sequence GMGIVMSLIVLAIVFGNVLVITAI description Helical; Name=1 source Swiss-Prot : SWS_FT_FI1 7) chain A residue 59-71 type TOPO_DOM sequence AFERLQTVTNYF description Cytoplasmic source Swiss-Prot : SWS_FT_FI2 8) chain A residue 130-150 type TOPO_DOM sequence DRYFAITSPFKYQSLLTKNKA description Cytoplasmic source Swiss-Prot : SWS_FT_FI2 9) chain A residue 221-274 type TOPO_DOM sequence RVFQEAKRQLQKIDKSEGRFHVKFCLKEHKALKT description Cytoplasmic source Swiss-Prot : SWS_FT_FI2 10) chain A residue 113 type BINDING sequence D description BINDING => ECO:0000269|PubMed:18547522, ECO:0007744|PDB:3D4S source Swiss-Prot : SWS_FT_FI10 11) chain A residue 118 type BINDING sequence T description BINDING => ECO:0000269|PubMed:18547522, ECO:0007744|PDB:3D4S source Swiss-Prot : SWS_FT_FI10 12) chain A residue 312 type BINDING sequence N description BINDING => ECO:0000269|PubMed:18547522, ECO:0007744|PDB:3D4S source Swiss-Prot : SWS_FT_FI10 13) chain A residue 316 type BINDING sequence Y description BINDING => ECO:0000269|PubMed:18547522, ECO:0007744|PDB:3D4S source Swiss-Prot : SWS_FT_FI10 14) chain A residue 203 type BINDING sequence S description BINDING => ECO:0000269|PubMed:17952055, ECO:0000269|PubMed:17962520, ECO:0007744|PDB:2RH1 source Swiss-Prot : SWS_FT_FI11 15) chain A residue 141 type MOD_RES sequence Y description Phosphotyrosine => ECO:0000269|PubMed:8521811 source Swiss-Prot : SWS_FT_FI12 16) chain A residue 345 type MOD_RES sequence S description Phosphoserine; by PKA => ECO:0000269|PubMed:11146000 source Swiss-Prot : SWS_FT_FI15 17) chain A residue 346 type MOD_RES sequence S description Phosphoserine; by PKA => ECO:0000269|PubMed:11146000 source Swiss-Prot : SWS_FT_FI15 18) chain A residue 265 type LIPID sequence C description S-palmitoyl cysteine => ECO:0000269|PubMed:27481942 source Swiss-Prot : SWS_FT_FI17 19) chain A residue 341 type LIPID sequence C description S-palmitoyl cysteine => ECO:0000269|PubMed:17962520, ECO:0000269|PubMed:18547522, ECO:0000269|PubMed:2540197, ECO:0000269|PubMed:27481942 source Swiss-Prot : SWS_FT_FI18 20) chain A residue 119-135 type prosite sequence ASIETLCVIAVDRYFAI description G_PROTEIN_RECEP_F1_1 G-protein coupled receptors family 1 signature. ASIeTLCVIAVDRYFaI source prosite : PS00237 21) chain L residue 192-198 type prosite sequence YTCEATH description IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YTCEATH source prosite : PS00290

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