eF-site ID 3ke8-B
PDB Code 3ke8
Chain B

click to enlarge
Title Crystal structure of IspH:HMBPP-complex
Classification OXIDOREDUCTASE
Compound 4-hydroxy-3-methylbut-2-enyl diphosphate reductase
Source null (ISPH_ECOLI)
Sequence B:  MQILLANPRGFCAGVDRAISIVENALAIYGAPIYVRHEVV
HNRYVVDSLRERGAIFIEQISEVPDGAILIFSAHGVSQAV
RNEAKSRDLTVFDATCPLVTKVHMEVARASRRGEESILIG
HAGHPEVEGTMGQYSNPEGGMYLVESPDDVWKLTVKNEEK
LSFMTQTTLSVDDTSDVIDALRKRFPKIVGPRKDDICYAT
TNRQEAVRALAEQAEVVLVVGSKNSSNSNRLAELAQRMGK
RAFLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQNVVA
RLQQLGGGEAIPLEGREENIVFEVPKELRV
Description


Functional site
1) chain B
residue 12
type
sequence C
description BINDING SITE FOR RESIDUE SF4 B 997
source : AC3
2) chain B
residue 14
type
sequence G
description BINDING SITE FOR RESIDUE SF4 B 997
source : AC3
3) chain B
residue 96
type
sequence C
description BINDING SITE FOR RESIDUE SF4 B 997
source : AC3
4) chain B
residue 98
type
sequence L
description BINDING SITE FOR RESIDUE SF4 B 997
source : AC3
5) chain B
residue 197
type
sequence C
description BINDING SITE FOR RESIDUE SF4 B 997
source : AC3
6) chain B
residue 15
type
sequence V
description BINDING SITE FOR RESIDUE EIP B 998
source : AC4
7) chain B
residue 40
type
sequence V
description BINDING SITE FOR RESIDUE EIP B 998
source : AC4
8) chain B
residue 41
type
sequence H
description BINDING SITE FOR RESIDUE EIP B 998
source : AC4
9) chain B
residue 73
type
sequence A
description BINDING SITE FOR RESIDUE EIP B 998
source : AC4
10) chain B
residue 74
type
sequence H
description BINDING SITE FOR RESIDUE EIP B 998
source : AC4
11) chain B
residue 99
type
sequence V
description BINDING SITE FOR RESIDUE EIP B 998
source : AC4
12) chain B
residue 124
type
sequence H
description BINDING SITE FOR RESIDUE EIP B 998
source : AC4
13) chain B
residue 126
type
sequence E
description BINDING SITE FOR RESIDUE EIP B 998
source : AC4
14) chain B
residue 167
type
sequence T
description BINDING SITE FOR RESIDUE EIP B 998
source : AC4
15) chain B
residue 168
type
sequence T
description BINDING SITE FOR RESIDUE EIP B 998
source : AC4
16) chain B
residue 224
type
sequence N
description BINDING SITE FOR RESIDUE EIP B 998
source : AC4
17) chain B
residue 225
type
sequence S
description BINDING SITE FOR RESIDUE EIP B 998
source : AC4
18) chain B
residue 226
type
sequence S
description BINDING SITE FOR RESIDUE EIP B 998
source : AC4
19) chain B
residue 227
type
sequence N
description BINDING SITE FOR RESIDUE EIP B 998
source : AC4
20) chain B
residue 269
type
sequence S
description BINDING SITE FOR RESIDUE EIP B 998
source : AC4
21) chain B
residue 12
type BINDING
sequence C
description BINDING => ECO:0000269|PubMed:20080550, ECO:0000269|PubMed:22137895, ECO:0000269|PubMed:22687151, ECO:0000269|PubMed:22948824, ECO:0000269|PubMed:23307751, ECO:0007744|PDB:3KE8, ECO:0007744|PDB:3SZL, ECO:0007744|PDB:3URK, ECO:0007744|PDB:4EB3, ECO:0007744|PDB:4H4C
source Swiss-Prot : SWS_FT_FI2
22) chain B
residue 96
type BINDING
sequence C
description BINDING => ECO:0000269|PubMed:20080550, ECO:0000269|PubMed:22137895, ECO:0000269|PubMed:22687151, ECO:0000269|PubMed:22948824, ECO:0000269|PubMed:23307751, ECO:0007744|PDB:3KE8, ECO:0007744|PDB:3SZL, ECO:0007744|PDB:3URK, ECO:0007744|PDB:4EB3, ECO:0007744|PDB:4H4C
source Swiss-Prot : SWS_FT_FI2
23) chain B
residue 197
type BINDING
sequence C
description BINDING => ECO:0000269|PubMed:20080550, ECO:0000269|PubMed:22137895, ECO:0000269|PubMed:22687151, ECO:0000269|PubMed:22948824, ECO:0000269|PubMed:23307751, ECO:0007744|PDB:3KE8, ECO:0007744|PDB:3SZL, ECO:0007744|PDB:3URK, ECO:0007744|PDB:4EB3, ECO:0007744|PDB:4H4C
source Swiss-Prot : SWS_FT_FI2
24) chain B
residue 225
type BINDING
sequence S
description BINDING => ECO:0000269|PubMed:20080550, ECO:0000269|PubMed:22137895, ECO:0000305|PubMed:22687151, ECO:0007744|PDB:3KE8, ECO:0007744|PDB:3SZL, ECO:0007744|PDB:4EB3
source Swiss-Prot : SWS_FT_FI3
25) chain B
residue 269
type BINDING
sequence S
description BINDING => ECO:0000269|PubMed:20080550, ECO:0000269|PubMed:22137895, ECO:0000305|PubMed:22687151, ECO:0007744|PDB:3KE8, ECO:0007744|PDB:3SZL, ECO:0007744|PDB:4EB3
source Swiss-Prot : SWS_FT_FI3
26) chain B
residue 41
type BINDING
sequence H
description BINDING => ECO:0000269|PubMed:20080550, ECO:0000269|PubMed:22137895, ECO:0000305|PubMed:22687151, ECO:0007744|PDB:3KE8, ECO:0007744|PDB:3SZL, ECO:0007744|PDB:4EB3
source Swiss-Prot : SWS_FT_FI3
27) chain B
residue 74
type BINDING
sequence H
description BINDING => ECO:0000269|PubMed:20080550, ECO:0000269|PubMed:22137895, ECO:0000305|PubMed:22687151, ECO:0007744|PDB:3KE8, ECO:0007744|PDB:3SZL, ECO:0007744|PDB:4EB3
source Swiss-Prot : SWS_FT_FI3
28) chain B
residue 124
type BINDING
sequence H
description BINDING => ECO:0000269|PubMed:20080550, ECO:0000269|PubMed:22137895, ECO:0000305|PubMed:22687151, ECO:0007744|PDB:3KE8, ECO:0007744|PDB:3SZL, ECO:0007744|PDB:4EB3
source Swiss-Prot : SWS_FT_FI3
29) chain B
residue 167
type BINDING
sequence T
description BINDING => ECO:0000269|PubMed:20080550, ECO:0000269|PubMed:22137895, ECO:0000305|PubMed:22687151, ECO:0007744|PDB:3KE8, ECO:0007744|PDB:3SZL, ECO:0007744|PDB:4EB3
source Swiss-Prot : SWS_FT_FI3
30) chain B
residue 126
type ACT_SITE
sequence E
description Proton donor => ECO:0000305|PubMed:22137895, ECO:0000305|PubMed:22687151
source Swiss-Prot : SWS_FT_FI1

Display surface

Download
Links